Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.48 |
| ▸ | MET | P08581 | 5/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987772 | 0.74 | PDE4B (0.49) | PDE4BPDE4DTRPV1 | |
| SCHEMBL9987982 | 0.71 | PDE4B (0.46) | PDE4BPDE4DNPC1ALDH1A1LMNA | |
| SCHEMBL10674017 | 0.70 | KMT2A (0.49) | PDE4BPDE4DMETTRPV1AHR | |
| SCHEMBL9986954 | 0.70 | TRPV1 (0.50) | PDE4BPDE4DTRPV1 | |
| SCHEMBL12035283 | 0.70 | PIK3CG (0.42) | PDE4BPDE4DALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9987445 | 0.69 | REN (0.40) | HPGDTP53ALDH1A1LMNAMAPT | |
| SCHEMBL7606599 | 0.67 | NPC1 (0.45) | NPC1RAB9A | |
| SCHEMBL9987354 | 0.67 | REN (0.38) | HPGDTP53LMNAMAPT | |
| SCHEMBL9986022 | 0.67 | KMT2A (0.42) | PDE4BPDE4DTRPV1AHRNPC1 | |
| SCHEMBL9986633 | 0.66 | PDE4B (0.41) | PDE4BPDE4DTRPV1AHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011163195-A1 | FUSED PYRROLE DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-12-29 | — | — | WO | disclosed |