Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TSPO | P30536 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987354 | 0.87 | REN (0.38) | RENHPGDLMNAMTNR1AMTNR1B | |
| SCHEMBL13737647 | 0.70 | PLA2G2A (0.43) | RENALDH1A1L3MBTL1HPGDMTNR1A | |
| SCHEMBL9987443 | 0.70 | NOTUM (0.42) | RENALDH1A1L3MBTL1HPGDLMNA | |
| SCHEMBL9987983 | 0.69 | PDE4B (0.48) | ALDH1A1HPGDLMNATP53MAPT | |
| SCHEMBL12035266 | 0.69 | CTSS (0.38) | ALDH1A1L3MBTL1HPGDLMNAHTT | |
| SCHEMBL7606599 | 0.68 | NPC1 (0.45) | — | |
| SCHEMBL20239638 | 0.67 | L3MBTL1 (0.59) | L3MBTL1NOTUMKDM4E | |
| SCHEMBL9986663 | 0.66 | VCP (0.36) | RENL3MBTL1NOTUMKDM4E | |
| SCHEMBL12074546 | 0.66 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1HPGDNOTUMMAPT | |
| SCHEMBL9987074 | 0.65 | NOTUM (0.46) | RENL3MBTL1HPGDLMNAELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011163195-A1 | FUSED PYRROLE DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-12-29 | — | — | WO | disclosed |