Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046506 | 0.81 | LMNA (0.68) | LMNATDP1CYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL427753 | 0.78 | CYP19A1 (0.70) | LMNATDP1CYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9988598 | 0.77 | LMNA (0.56) | LMNATDP1CYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4458510 | 0.77 | FFAR4 (0.52) | LMNATDP1CYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL30535283 | 0.73 | LMNA (0.82) | LMNATDP1CYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL676142 | 0.73 | LMNA (0.82) | LMNATDP1CYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL919761 | 0.73 | LMNA (0.58) | LMNATDP1CYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2196501 | 0.72 | CYP19A1 (0.71) | LMNATDP1CYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL12562322 | 0.72 | CYP19A1 (0.71) | LMNATDP1CYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4477201 | 0.71 | LMNA (0.56) | LMNATDP1CYP19A1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2397462-A2 | Compounds, compositions and methods of treatment for heart failure | Cytokinetics, Inc. (US) | 2011-12-21 | — | — | EP | disclosed |