Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846059 | 0.71 | ADORA2A (0.46) | ADORA2AADORA1SMN1; SMN2ALDH1A1TAAR1 | |
| SCHEMBL18322395 | 0.71 | — | — | |
| SCHEMBL16741024 | 0.69 | — | — | |
| SCHEMBL16600770 | 0.69 | TAAR1 (0.40) | ADORA2AADORA1SMN1; SMN2TAAR1MAPT | |
| SCHEMBL791033 | 0.68 | — | — | |
| SCHEMBL9987892 | 0.68 | HSD11B1 (0.42) | SMN1; SMN2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL13562467 | 0.68 | SLC5A2 (0.47) | ADORA2AADORA1SMN1; SMN2ALDH1A1TAAR1 | |
| SCHEMBL18322711 | 0.67 | — | — | |
| SCHEMBL29519238 | 0.67 | IDO1 (0.62) | TAAR1NPC1RAB9APNMTIDO1 | |
| SCHEMBL672407 | 0.67 | IDO1 (0.62) | TAAR1NPC1RAB9APNMTIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2397462-A2 | Compounds, compositions and methods of treatment for heart failure | Cytokinetics, Inc. (US) | 2011-12-21 | — | — | EP | claimed |