Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | HPGDS | O60760 | 1/20 | 0.54 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.50 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 3/20 | 0.48 |
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | GCK | P35557 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9991288 | 0.81 | NPC1 (0.60) | NPC1RAB9AHPGDSRPS6KA3RPS6KA2 | |
| SCHEMBL9989122 | 0.76 | PLK1 (0.48) | HPGDSHTTSMN1; SMN2 | |
| SCHEMBL9991291 | 0.76 | NPC1 (0.33) | NPC1RAB9AHPGDSMAPK1ALDH1A1 | |
| SCHEMBL21590291 | 0.74 | NPC1 (0.75) | NPC1RAB9AHPGDSMAPK1MAPK7 | |
| SCHEMBL22490239 | 0.74 | NPC1 (0.66) | NPC1RAB9AHPGDSRPS6KA3RPS6KA2 | |
| SCHEMBL25402169 | 0.74 | HDAC6 (0.46) | — | |
| SCHEMBL17112019 | 0.74 | RAB9A (0.56) | NPC1RAB9AMAPK1KDM4EALDH1A1 | |
| SCHEMBL27061741 | 0.73 | TP53 (0.47) | NPC1RAB9AHPGDSRETKDM4E | |
| SCHEMBL25753506 | 0.72 | MAPT (0.50) | NPC1RAB9AHPGDSKDRALDH1A1 | |
| SCHEMBL2667078 | 0.72 | NPC1 (0.66) | NPC1RAB9AHPGDSRPS6KA3RPS6KA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110319379-A1 | Substituted Indazole Amides And Their Use As Glucokinase Activators | CORBETT JEFFREY W (US) | 2011-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319379-A1 | Substituted Indazole Amides And Their Use As Glucokinase Activators | GCKR, GCK, GALK1 | NPC1 2208/4885RAB9A 1995/4885HPGDS 3551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.