Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.66 |
| ▸ | RAB9A | P51151 | 6/20 | 0.66 |
| ▸ | MTOR | P42345 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.46 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21590291 | 0.81 | NPC1 (0.75) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL23884739 | 0.76 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL12579391 | 0.76 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2667078 | 0.76 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL22490159 | 0.75 | MTOR (0.44) | NPC1RAB9AMTORSMN1; SMN2LMNA | |
| SCHEMBL1376302 | 0.75 | NPC1 (0.74) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL12579765 | 0.75 | NPC1 (0.75) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL9991288 | 0.75 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL1800369 | 0.75 | GRM5 (0.63) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL9989116 | 0.74 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198053-A1 | 2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-4-METHYLBENZAMIDE DERIVATIVES AND SIMILAR COMPOUNDS AS RIPK2 INHIBITORS FOR TREATING E.G. AUTOIMMUNE DISEASES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2020-10-01 | — | — | WO | disclosed |