Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.30 |
| ▸ | FEN1 | P39748 | 2/20 | 0.30 |
| ▸ | PLK4 | O00444 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | INSR | P06213 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | FES | P07332 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31399703 | 0.76 | ALDH1A1 (0.54) | ALDH1A1ESR1CYP1A2CYP2C19TSHR | |
| SCHEMBL23795318 | 0.76 | ALDH1A1 (0.54) | ALDH1A1ESR1CYP1A2CYP2C19TSHR | |
| SCHEMBL27739484 | 0.69 | CYP2A6 (0.50) | ALDH1A1CYP2C19TSHR | |
| SCHEMBL12072176 | 0.65 | KDM4E (0.48) | ALDH1A1CYP1A2CYP2C19ALOX5APFEN1 | |
| SCHEMBL28507433 | 0.65 | KDM4E (0.37) | ALDH1A1CYP1A2CYP2C19PLK4AURKA | |
| SCHEMBL24876036 | 0.65 | HPRT1 (0.33) | ALDH1A1PLK4AURKAPDPK1JAK2 | |
| SCHEMBL15428059 | 0.65 | CYP2A6 (0.43) | ALDH1A1ESR1CYP1A2 | |
| SCHEMBL19932296 | 0.65 | KDM4E (0.38) | ALOX5APFEN1PLK4AURKAPDPK1 | |
| SCHEMBL3141268 | 0.65 | PDE4A (0.43) | ALDH1A1CYP1A2AURKA | |
| SCHEMBL29773646 | 0.64 | ERN1 (0.37) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1852421-B1 | PROCESS FOR PRODUCTION OF 4-FLUOROISOQUINOLINE-5-SULFONYL HALIDE OR SALT THEREOF | KOWA CO (JP) | 2011-05-04 | — | — | EP | claimed |
| US-7872136-B2 | Process for production of 4-fluoroisoquinoline-5-sulfonyl halide or salt thereof | KOWA CO., LTD. (JP) | 2011-01-18 | — | — | US | claimed |
| US-20090209765-A1 | PROCESS FOR PRODUCTION OF 4-FLUOROISOQUINOLINE-5-SULFONYL HALIDE OR SALT THEREOF | KOWA CO., LTD. (JP) | 2009-08-20 | — | — | US | claimed |
| EP-1852421-A1 | PROCESS FOR PRODUCTION OF 4-FLUOROISOQUINOLINE-5-SULFONYL HALIDE OR SALT THEREOF | Kowa Company, Ltd. (JP) | 2007-11-07 | — | — | EP | claimed |
| EP-1852421-B1 | PROCESS FOR PRODUCTION OF 4-FLUOROISOQUINOLINE-5-SULFONYL HALIDE OR SALT THEREOF | KOWA CO (JP) | 2011-05-04 | — | — | EP | disclosed |
| US-7872136-B2 | Process for production of 4-fluoroisoquinoline-5-sulfonyl halide or salt thereof | KOWA CO., LTD. (JP) | 2011-01-18 | — | — | US | disclosed |
| US-20090209765-A1 | PROCESS FOR PRODUCTION OF 4-FLUOROISOQUINOLINE-5-SULFONYL HALIDE OR SALT THEREOF | KOWA CO., LTD. (JP) | 2009-08-20 | — | — | US | disclosed |
| EP-1852421-A1 | PROCESS FOR PRODUCTION OF 4-FLUOROISOQUINOLINE-5-SULFONYL HALIDE OR SALT THEREOF | Kowa Company, Ltd. (JP) | 2007-11-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209765-A1 | PROCESS FOR PRODUCTION OF 4-FLUOROISOQUINOLINE-5-SULFONYL HALIDE OR SALT THEREOF | SALL4, STS, SFPQ | ALDH1A1 783/4885ESR1 4794/4885CYP1A2 968/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.