Phloroglucinol

Phloroglucinol

SCHEMBL999214

Oc1cc(O)cc(O)c1.Oc1cccc(O)c1O

nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8

The experimentally established mechanism targets of Phloroglucinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1B known ✓ Q00975 1/20 0.46
ALDH1A1 P00352 5/20 0.75
LMNA P02545 4/20 0.75
HSD17B10 Q99714 4/20 0.75
CA2 P00918 3/20 0.75
HPGD P15428 3/20 0.75
ALOX15 P16050 3/20 0.75
EGFR P00533 2/20 0.75
FYN P06241 2/20 0.75
MMP9 P14780 2/20 0.75
RECQL P46063 2/20 0.75
TDP1 Q9NUW8 2/20 0.75
ADAMTS4 O75173 1/20 0.75
CA1 P00915 1/20 0.75
MMP2 P08253 1/20 0.75
MMP8 P22894 1/20 0.75
CA6 P23280 1/20 0.75
CDK2 P24941 1/20 0.75
MMP12 P39900 1/20 0.75
ADAMTS5 Q9UNA0 1/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phloroglucinol SCHEMBL5703345 0.94 ALDH1A1 (0.67) ALDH1A1LMNAHSD17B10CA2HPGD
Phloroglucinol SCHEMBL11729953 0.94 ALDH1A1 (0.67) ALDH1A1LMNAHSD17B10CA2HPGD
Phloroglucinol SCHEMBL28193973 0.92 ALDH1A1 (0.63) ALDH1A1LMNAHSD17B10CA2HPGD
Pyrogallol SCHEMBL999213 0.91 ALDH1A1 (0.71) ALDH1A1LMNAHSD17B10CA2HPGD
Pyrogallol SCHEMBL8833424 0.91 ALDH1A1 (0.71) ALDH1A1LMNAHSD17B10CA2HPGD
Phloroglucinol SCHEMBL27975020 0.89 CA2 (0.60) ALDH1A1LMNAHSD17B10CA2HPGD
Orcinol SCHEMBL11406741 0.87 ALDH1A1 (0.57) ALDH1A1LMNAHSD17B10CA2HPGD
Pyrogallol SCHEMBL170157 0.87 ALDH1A1 (1.00) ALDH1A1LMNAHSD17B10CA2HPGD
Pyrogallol SCHEMBL3532 0.87
Pyrogallol SCHEMBL28049935 0.86 CA2 (0.63) ALDH1A1LMNAHSD17B10CA2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0377308-A1 Phenolic resins BORDEN (UK) LIMITED (GB) 1990-07-11 EP claimed
WO-2023046903-A1 TANNIN-BASED NON-ISOCYANATE POLYURETHANE ADHESIVES ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) 2023-03-30 WO disclosed
EP-4155338-A1 TANNIN-BASED NON-ISOCYANATE POLYURETHANE ADHESIVES Albert-Ludwigs-Universität Freiburg (DE) 2023-03-29 EP disclosed
EP-2448733-B1 NATURAL FIBER AND RESIN COMPOSITE MATERIAL UNIV LORRAINE (FR) 2013-06-05 EP disclosed
EP-2448733-A1 NATURAL FIBER AND RESIN COMPOSITE MATERIAL Université Henri Poincaré Nancy 1 (FR) 2012-05-09 EP disclosed
EP-2400344-A1 Positive photosensitive resin composition Everlight USA, Inc. (US) 2011-12-28 EP disclosed
WO-2011001105-A1 NATURAL FIBER AND RESIN COMPOSITE MATERIAL UNIVERSITE HENRI POINCARE NANCY 1 (FR) 2011-01-06 WO disclosed
EP-0117469-B2 Hair cosmetics KAO CORP (JP) 1996-09-04 EP disclosed
EP-0463171-B1 Method of determining fructosamines IATRON LAB (JP) 1996-04-17 EP disclosed
US-5312759-A Method for measurement of fructosamines using 1,2-quinones IATRON LABORATORIES, INC. (JP) 1994-05-17 US disclosed
EP-0463171-A1 Method of determining fructosamines IATRON LABORATORIES, INC. (JP) 1992-01-02 EP disclosed
US-4839168-A PLANT EXTRACT AND POLYPEPTIDE COMPOUND KAO CORPORATION (JP) 1989-06-13 US disclosed
EP-0117469-B1 HAIR COSMETICS Kao Corporation (JP) 1988-04-20 EP disclosed
EP-0117469-A1 Hair cosmetics Kao Corporation (JP) 1984-09-05 EP disclosed