Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LDHA | P00338 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclopentane SCHEMBL9994808 | 1.00 | RAB9A (0.52) | RAB9ASMN1; SMN2HSD17B10MAPTNPC1 | |
| Cyclopentane SCHEMBL9994781 | 1.00 | RAB9A (0.52) | RAB9ASMN1; SMN2HSD17B10MAPTNPC1 | |
| Cyclopropane SCHEMBL9994801 | 1.00 | RAB9A (0.52) | RAB9ASMN1; SMN2HSD17B10MAPTNPC1 | |
| Cyclohexane SCHEMBL9994983 | 1.00 | RAB9A (0.52) | RAB9ASMN1; SMN2HSD17B10MAPTNPC1 | |
| Cyclohexane SCHEMBL9995190 | 1.00 | RAB9A (0.52) | RAB9ASMN1; SMN2HSD17B10MAPTNPC1 | |
| SCHEMBL9994799 | 1.00 | RAB9A (0.52) | RAB9ASMN1; SMN2HSD17B10MAPTNPC1 | |
| Cyclopropane SCHEMBL9994713 | 1.00 | RAB9A (0.52) | RAB9ASMN1; SMN2HSD17B10MAPTNPC1 | |
| SCHEMBL9994885 | 1.00 | RAB9A (0.52) | RAB9ASMN1; SMN2HSD17B10MAPTNPC1 | |
| SCHEMBL1744132 | 0.90 | LDHA (0.53) | RAB9ASMN1; SMN2HSD17B10MAPTNPC1 | |
| SCHEMBL1744133 | 0.90 | LDHA (0.53) | RAB9ASMN1; SMN2HSD17B10MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2386556-B1 | Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands | ABBVIE INC (US) | 2013-10-23 | — | — | EP | claimed |
| EP-1926729-B1 | BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTORS LIGANDS | ABBOTT LAB (US) | 2011-12-21 | — | — | EP | claimed |