Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19262987 | 0.90 | TSHR (0.64) | CYP1A2TSHRNFKB1MAOBMEN1 | |
| SCHEMBL25018799 | 0.89 | CYP1A2 (0.54) | CYP1A2TSHRNFKB1MAOBMEN1 | |
| SCHEMBL14159023 | 0.88 | CYP1A2 (0.63) | CYP1A2TSHRNFKB1MAOBMEN1 | |
| SCHEMBL14758320 | 0.87 | HPGD (0.52) | CYP1A2TSHRNFKB1MAOBMEN1 | |
| SCHEMBL17208760 | 0.83 | L3MBTL1 (0.59) | TSHRMEN1KMT2AEPHX2NR1H4 | |
| SCHEMBL22042366 | 0.83 | MAPK1 (0.51) | EPHX2NR1H4ALDH1A1MAPK1NPC1 | |
| SCHEMBL27447913 | 0.83 | EPHX2 (0.49) | EPHX2NR1H4ALDH1A1MAPK1NPC1 | |
| SCHEMBL13063463 | 0.83 | EPHX2 (0.51) | CYP1A2TSHRNFKB1MAOBMEN1 | |
| SCHEMBL3523157 | 0.82 | MAPK1 (0.61) | CYP1A2TSHRNFKB1MAOBMEN1 | |
| SCHEMBL18844389 | 0.82 | L3MBTL1 (0.67) | MEN1KMT2AEPHX2NR1H4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015163952-A1 | ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE (US) | 2015-10-29 | — | — | WO | disclosed |
| EP-2398822-B1 | MODIFICATION OF FACTOR VIII | NOVO NORDISK AS (DK) | 2013-01-02 | — | — | EP | disclosed |
| EP-2398822-B1 | MODIFICATION OF FACTOR VIII | NOVO NORDISK AS (DK) | 2013-01-02 | — | — | EP | disclosed |
| US-20110306551-A1 | Modification of Factor VIII | NOVO NORDISK A/S (DK) | 2011-12-15 | — | — | US | disclosed |
| US-20110306551-A1 | Modification of Factor VIII | NOVO NORDISK A/S (DK) | 2011-12-15 | — | — | US | disclosed |
| US-20110306551-A1 | Modification of Factor VIII | NOVO NORDISK A/S (DK) | 2011-12-15 | — | — | US | disclosed |
| WO-2010102886-A1 | MODIFICATION OF FACTOR VIII | NOVO NORDISK A/S (DK) | 2010-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306551-A1 | Modification of Factor VIII | F8, F9, F13B | CYP1A2 1139/4885TSHR 3988/4885NFKB1 76/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.