Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763325 | 0.82 | HPGD (0.50) | KDM4EALDH1A1HPGD | |
| SCHEMBL9998261 | 0.76 | MAPT (0.49) | — | |
| SCHEMBL9998442 | 0.75 | NR4A2 (0.54) | KDM4EHPGD | |
| SCHEMBL4498016 | 0.72 | MEN1 (0.52) | KDM4EALDH1A1HPGD | |
| SCHEMBL9998826 | 0.72 | MEN1 (0.52) | KDM4EALDH1A1HPGD | |
| SCHEMBL13694666 | 0.72 | KDM4E (0.61) | KDM4EHPGD | |
| SCHEMBL14260722 | 0.71 | KDM4E (0.74) | KDM4EHPGD | |
| SCHEMBL4763412 | 0.69 | PLK1 (0.51) | — | |
| SCHEMBL10165837 | 0.68 | KDM4E (0.74) | KDM4EHPGD | |
| SCHEMBL2407014 | 0.68 | HDAC1 (0.52) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917262-B1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2011-12-14 | — | — | EP | disclosed |