Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | C5 | P01031 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RXRB | P28702 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4766610 | 0.82 | NR4A2 (0.54) | NR4A2KDM4EABCC4C5LMNA | |
| SCHEMBL9998261 | 0.77 | MAPT (0.49) | — | |
| SCHEMBL9998326 | 0.75 | KDM4E (0.48) | KDM4EHPGD | |
| SCHEMBL4498016 | 0.73 | MEN1 (0.52) | KDM4EHPGDCYP2C19 | |
| SCHEMBL9998826 | 0.73 | MEN1 (0.52) | KDM4EHPGDCYP2C19 | |
| Oxaprozin SCHEMBL20657782 | 0.72 | LMNA (0.61) | NR4A2KDM4EABCC4C5LMNA | |
| SCHEMBL21675691 | 0.72 | NR4A2 (1.00) | NR4A2KDM4EABCC4C5LMNA | |
| SCHEMBL31582641 | 0.70 | NR4A2 (0.77) | NR4A2KDM4EABCC4C5LMNA | |
| SCHEMBL21675690 | 0.70 | NR4A2 (0.76) | NR4A2KDM4EABCC4C5LMNA | |
| SCHEMBL17208133 | 0.70 | RXRA (0.72) | NR4A2KDM4EABCC4C5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917262-B1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2011-12-14 | — | — | EP | disclosed |