ACTN1

Alpha-actinin-1 · P12814 · ACTN1 on Sugi Atlas →

0 patent compounds predicted against ACTN1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to ACTN1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Lifestyle and Pharmacological Interventions in Hypertrophic Cardiomyopathy PHASE2/PHASE3COMPLETED
Sacubitril/Valsartan vs Lifestyle in Hypertrophic Cardiomyopathy PHASE2COMPLETED
A Clinical Study to Evaluate the Safety, Tolerability, and Efficacy of BBM-D101 in the Treatment of Duchenne Muscular Dystrophy. PHASE1/PHASE2RECRUITING
A Study to Assess the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of Intravenous Administration of ARGX-119 in Pediatric Participants Aged 5 to Less Than 18 Years With Spinal Muscular Atrophy PHASE2RECRUITING
Evaluating MED2005 & Nitrostat Bioavailability PHASE1COMPLETED
Evaluation of the Safety and Efficacy of BBM-D101 to Treat Patients with Duchenne Muscular Dystrophy EARLY_PHASE1RECRUITING
Study of Genotype and Phenotype Characterization in Duchenne Muscular Dystrophy With Small Mutations nanUNKNOWN
Muscle Tissue Bank for Muscular Dystrophy nanCOMPLETED
Transcutaneous Functional Magnetic Muscle Stimulation in Critically Ill nanUNKNOWN
Natural History Study for Patients With Nemaline Myopathy in Belgium nanNOT_YET_RECRUITING
Molecular Analysis of Patients With Neuromuscular Disease nanRECRUITING
Effect of Exercise on the Human Skeletal Muscle Phosphoproteome nanCOMPLETED
Pediatric Cardiomyopathy Mutation Analysis nanRECRUITING
Clinical Outcome Study for Dysferlinopathy nanUNKNOWN
CCM Italian Registry nanUNKNOWN
Newborn Screening for Spinal Muscular Atrophy nanCOMPLETED
3D-Microscopic Muscle Architecture in Cerebral Palsy nanRECRUITING
Signs and Symptoms Associated With Molecular Defects in Genetically Inherited Heart Disease nanCOMPLETED
Clinical and Biochemical Features for the Identification of Dominant Calpainopathies nanUNKNOWN
Post-exercise Dietary Protein Strategies nanCOMPLETED
The Prevalence of RYR1-related Disease nanNOT_YET_RECRUITING
Aerobic Training in Patients With Spinal Muscular Atrophy Type III nanCOMPLETED
A Multicenter Phenotype-Genotype Analysis of LGMD Patients in China nanENROLLING_BY_INVITATION
Spinal Muscular Atrophy (SMA) Biomarkers Study in the Immediate Postnatal Period of Development nanCOMPLETED
Palliative Care in Spinal Muscular Atrophy (SMA) 1 nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Phenotype - Genotype Correlation in a Sample of Egyptian Patients With Congenital Myopathies and Congenital Muscular Dystrophies nanRECRUITING
Dentatorubral-pallidoluysian Atrophy Natural History and Biomarkers Study nanUNKNOWN
WiTNNess - TNNT1 Myopathy Natural History Study nanRECRUITING
The Muscle in Cerebral Palsy; Sarcomere Length in Vivo and Microscopic Characterization of Biopsies. nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a ACTN1 binder may also engage these)

ProteinNameSimilarity
Q3B7N2 1.000 Q3B7N2 →
Q2PFV7 1.000 Q2PFV7 →
Q90734 1.000 Q90734 →
A5D7D1 1.000 A5D7D1 →
Q7TPR4 1.000 Q7TPR4 →
Q9Z1P2 1.000 Q9Z1P2 →
ACTN4 Alpha-actinin-4 1.000 landscape →
P57780 1.000 P57780 →
Q5RCS6 1.000 Q5RCS6 →
Q9QXQ0 1.000 Q9QXQ0 →
P05094 1.000 P05094 →
Q9JI91 0.998 Q9JI91 →
Q3ZC55 0.997 Q3ZC55 →
P35609 0.997 P35609 →
Q08043 0.996 Q08043 →
O88990 0.994 O88990 →
P20111 0.994 P20111 →
Q7PKQ5 0.993 Q7PKQ5 →
P18091 0.991 P18091 →
L7UZ85 0.991 L7UZ85 →
Q0III9 0.986 Q0III9 →
Q62261 0.983 Q62261 →
SPTBN1 Spectrin beta chain, non-erythrocytic 1 0.980 landscape →
Q00963 0.973 Q00963 →
Q9VUV9 0.966 Q9VUV9 →
IQGAP1 Ras GTPase-activating-like protein IQGAP1 0.965 landscape →
Q13576 0.965 Q13576 →
Q5R416 0.965 Q5R416 →
Q3UQ44 0.964 Q3UQ44 →
Q5M7J9 0.964 Q5M7J9 →