ACTN4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Molibresib (SCHEMBL1872390)	1.00	1/20
Molibresib (SCHEMBL12671490)	1.00	1/20
Molibresib (SCHEMBL12966358)	1.00	1/20
SCHEMBL9998851	0.91	1/20
SCHEMBL14756282	0.88	1/20
SCHEMBL15980874	0.88	1/20
SCHEMBL12966165	0.87	1/20
SCHEMBL14756215	0.87	1/20
SCHEMBL14756339	0.87	1/20
SCHEMBL15980861	0.87	1/20
SCHEMBL9998825	0.86	1/20
SCHEMBL15980893	0.86	1/20
SCHEMBL15980803	0.86	1/20
SCHEMBL1874116	0.85	1/20
SCHEMBL12671221	0.85	1/20
SCHEMBL14756021	0.85	1/20
SCHEMBL14756240	0.85	1/20
SCHEMBL14756287	0.85	1/20
SCHEMBL14756335	0.85	1/20
SCHEMBL14756409	0.85	1/20

Clinical trials — most relevant to ACTN4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Treatment of Preclinical Hypertrophic Cardiomyopathy With Diltiazem	PHASE2/PHASE3	COMPLETED
Empagliflozin in Hypertrophic Cardiomyopathy	PHASE3	ACTIVE_NOT_RECRUITING
Sacubitril/Valsartan vs Lifestyle in Hypertrophic Cardiomyopathy	PHASE2	COMPLETED
A Study to Assess the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of Intravenous Administration of ARGX-119 in Pediatric Participants Aged 5 to Less Than 18 Years With Spinal Muscular Atrophy	PHASE2	RECRUITING
Evaluating MED2005 & Nitrostat Bioavailability	PHASE1	COMPLETED
Evaluation of the Safety and Efficacy of BBM-D101 to Treat Patients with Duchenne Muscular Dystrophy	EARLY_PHASE1	RECRUITING
Study of Genotype and Phenotype Characterization in Duchenne Muscular Dystrophy With Small Mutations	nan	UNKNOWN
Muscle Tissue Bank for Muscular Dystrophy	nan	COMPLETED
Natural History Study for Patients With Nemaline Myopathy in Belgium	nan	NOT_YET_RECRUITING
Pediatric Cardiomyopathy Mutation Analysis	nan	RECRUITING
Effect of Exercise on the Human Skeletal Muscle Phosphoproteome	nan	COMPLETED
CCM Italian Registry	nan	UNKNOWN
Clinical Outcome Study for Dysferlinopathy	nan	UNKNOWN
The Muscle in Cerebral Palsy; Sarcomere Length in Vivo and Microscopic Characterization of Biopsies.	nan	RECRUITING
Spinal Muscular Atrophy (SMA) Biomarkers Study in the Immediate Postnatal Period of Development	nan	COMPLETED
Signs and Symptoms Associated With Molecular Defects in Genetically Inherited Heart Disease	nan	COMPLETED
Molecular Mechanisms of Exercise Benefits to Insulin Resistant People	nan	COMPLETED
Observational Study on Cardiac Biomarkers Testing in Patients with Muscular Dystrophy Cardiomyopathy	nan	COMPLETED
Brain Involvement in Dystrophinopathies Part 2	nan	COMPLETED
Phenotype - Genotype Correlation in a Sample of Egyptian Patients With Congenital Myopathies and Congenital Muscular Dystrophies	nan	RECRUITING
A Multicenter Phenotype-Genotype Analysis of LGMD Patients in China	nan	ENROLLING_BY_INVITATION
Newborn Screening for Spinal Muscular Atrophy	nan	COMPLETED
Heart and Skeletal Muscle Problems in Neuroacanthocytosis	nan	COMPLETED
CoMPaSS-NMD - Computational Models for New Patients Stratification Strategies of HNMD	nan	ENROLLING_BY_INVITATION
Role of Ultrasound in Diagnosis of Muscle Diseases	nan	COMPLETED
Molecular Analysis of Patients With Neuromuscular Disease	nan	RECRUITING
Transcutaneous Functional Magnetic Muscle Stimulation in Critically Ill	nan	UNKNOWN
New Diagnostic Strategy in Hypertrophic Cardiomyopathy	nan	UNKNOWN
Family Blood Pressure Program - GenNet Network	nan	COMPLETED
Nerve Ultrasound in Acquired and Genetic Sensory Neuronopathies	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a ACTN4 binder may also engage these)

Protein	Name	Similarity
A5D7D1	—	1.000	A5D7D1 →
Q5RCS6	—	1.000	Q5RCS6 →
P57780	—	1.000	P57780 →
Q90734	—	1.000	Q90734 →
Q9QXQ0	—	1.000	Q9QXQ0 →
Q2PFV7	—	1.000	Q2PFV7 →
Q3B7N2	—	1.000	Q3B7N2 →
Q9Z1P2	—	1.000	Q9Z1P2 →
Q7TPR4	—	1.000	Q7TPR4 →
ACTN1	Alpha-actinin-1	1.000	landscape →
P05094	—	1.000	P05094 →
Q9JI91	—	1.000	Q9JI91 →
Q3ZC55	—	1.000	Q3ZC55 →
P35609	—	1.000	P35609 →
Q08043	—	1.000	Q08043 →
O88990	—	0.998	O88990 →
Q7PKQ5	—	0.997	Q7PKQ5 →
P20111	—	0.997	P20111 →
P18091	—	0.994	P18091 →
L7UZ85	—	0.994	L7UZ85 →
Q0III9	—	0.990	Q0III9 →
Q62261	—	0.987	Q62261 →
SPTBN1	Spectrin beta chain, non-erythrocytic 1	0.984	landscape →
Q00963	—	0.978	Q00963 →
Q9VUV9	—	0.971	Q9VUV9 →
Q13576	—	0.971	Q13576 →
Q3UQ44	—	0.970	Q3UQ44 →
Q9FKI0	—	0.970	Q9FKI0 →
Q5R416	—	0.970	Q5R416 →
IQGAP1	Ras GTPase-activating-like protein IQGAP1	0.970	landscape →