AHCYL1

S-adenosylhomocysteine hydrolase-like protein 1 · O43865 · AHCYL1 on Sugi Atlas →

159 patent compounds predicted against AHCYL1, 142 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL17532522	1.00	4/20
SCHEMBL17532523	1.00	4/20
SCHEMBL17532524	1.00	4/20
SCHEMBL17532526	1.00	4/20
SCHEMBL18878458	0.81	4/20
SCHEMBL18878459	0.72	4/20
SCHEMBL18878461	0.80	3/20
SCHEMBL18878460	0.70	3/20
SCHEMBL17532525	0.67	3/20
SCHEMBL17501744	0.65	3/20
SCHEMBL17501761	0.65	3/20
SCHEMBL17528508	0.65	3/20
SCHEMBL29361147	0.65	3/20
3-Deazaneplanocin A (SCHEMBL863851)	0.65	2/20
3-Deazaneplanocin A (SCHEMBL874126)	0.65	2/20
3-Deazaneplanocin A (SCHEMBL1521229)	0.65	2/20
3-Deazaneplanocin A (SCHEMBL12280318)	0.65	2/20
3-Deazaneplanocin A (SCHEMBL12280736)	0.65	2/20
3-Deazaneplanocin A (SCHEMBL12321313)	0.65	2/20
3-Deazaneplanocin A (SCHEMBL13663976)	0.65	2/20

Clinical trials — most relevant to AHCYL1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor	PHASE1/PHASE2	NOT_YET_RECRUITING
Folate Rechallenge	PHASE2	COMPLETED
Phase 1/ Phase 2 Study to Assess Safety and Efficacy of Orally Administered JBI-802 in Subjects With Myeloproliferative Neoplasms (MPN) and Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN) With Thrombocytosis	PHASE1/PHASE2	RECRUITING
Effect of S-adenosylmethionine (SAMe) on Blood Levels of Homocysteine	PHASE1	COMPLETED
Uterine Artery Doppler Changes After Vaginal Administration of Isosorbide Mononitrate In Patients With URPL	EARLY_PHASE1	UNKNOWN
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients.	nan	COMPLETED
Role of a Dietary Supplement in Lowering SAH in Healthy Adults With Elevated Plasma SAH and Normal Homocysteine Levels	nan	COMPLETED
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer	nan	UNKNOWN
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart	nan	UNKNOWN
Proof of Concept Creatine Supplementation for Homocystinuria Study	nan	ACTIVE_NOT_RECRUITING
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Treating Oxidative Stress and the Metabolic Pathology of Autism	nan	COMPLETED
The Effect of Dietary Management and Cysteine Supplementation on Growth Parameters and Biochemical Control for Pediatric Qatari Patients Affected with Classical B6 Non-responsive Homocystinuria.	nan	NOT_YET_RECRUITING
Homocysteine and Coronary Artery Disease	nan	COMPLETED
The Roles of SAH Gene Family in Athrogenic Dyslipidemia in Postmenopausal Women	nan	UNKNOWN
Harmonized Micronutrient Project	nan	COMPLETED
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients	nan	COMPLETED
Effects of Exercise on Metabolic Parameters in Classical Homocystinuria	nan	COMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
S-adenosylmethionine Plus Choline in Treatment of Patients With Alcoholic Liver Disease	nan	UNKNOWN
Human Lipoprotein Pathophysiology - Subproject: Genetics of Familial Combined Hyperlipidemia	nan	COMPLETED
Identification of Acute Intermittent Porphyria Modifying Genes	nan	RECRUITING
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD	nan	NOT_YET_RECRUITING
Adenosylmethionine Metabolism in Human Inflammation	nan	UNKNOWN
5-methyltetrahydrofolate Survival and Inflammation in ESRD Patients	nan	COMPLETED
Natural History Study of Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency (ACAPPELLA)	nan	RECRUITING
Targeting zDHHC Enzymes to Counteract Alzheimer's Disease	nan	NOT_YET_RECRUITING
Diabetic Cardiomyopathy and Heart Failure	nan	WITHDRAWN
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione	nan	COMPLETED
Genetical Background of Non-alcoholic Fatty Liver Disease (NAFLD) in Diabetes Mellitus and in Chronic Kidney Disease	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a AHCYL1 binder may also engage these)

Protein	Name	Similarity
B5DFN2	—	1.000	B5DFN2 →
Q80SW1	—	1.000	Q80SW1 →
P50245	—	0.999	P50245 →
Q5R889	—	0.999	Q5R889 →
Q9VZX9	—	0.998	Q9VZX9 →
Q8A407	—	0.996	Q8A407 →
Q9LK36	—	0.995	Q9LK36 →
A1VFZ7	—	0.995	A1VFZ7 →
P51540	—	0.994	P51540 →
Q3AQC2	—	0.994	Q3AQC2 →
P35007	—	0.994	P35007 →
Q01781	—	0.994	Q01781 →
P50246	—	0.994	P50246 →
Q96HN2	—	0.994	Q96HN2 →
B7V419	—	0.994	B7V419 →
O23255	—	0.993	O23255 →
Q72EH1	—	0.993	Q72EH1 →
A5GI30	—	0.993	A5GI30 →
A6QLP2	—	0.993	A6QLP2 →
Q6FA43	—	0.993	Q6FA43 →
Q4K4H7	—	0.993	Q4K4H7 →
B3QMF5	—	0.992	B3QMF5 →
Q13T36	—	0.992	Q13T36 →
Q0IDX7	—	0.992	Q0IDX7 →
B1XSH8	—	0.992	B1XSH8 →
Q9I685	—	0.992	Q9I685 →
B0KM00	—	0.992	B0KM00 →
Q3K5D7	—	0.992	Q3K5D7 →
P61617	—	0.992	P61617 →
A5WA09	—	0.992	A5WA09 →