AMPD1

AMP deaminase 1 · P23109 · AMPD1 on Sugi Atlas →

148 patent compounds predicted against AMPD1, 21 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL20915109	0.57	4/20
SCHEMBL13415334	0.49	3/20
SCHEMBL31415088	0.46	2/20
Coformycin (SCHEMBL11184406)	0.46	2/20
Coformycin (SCHEMBL14031897)	0.46	2/20
SCHEMBL29519718	0.46	2/20
Pentostatin (SCHEMBL2818)	0.45	2/20
Pentostatin (SCHEMBL1649740)	0.45	2/20
Pentostatin (SCHEMBL2045053)	0.45	2/20
Pentostatin (SCHEMBL5549091)	0.45	2/20
Pentostatin (SCHEMBL14031902)	0.45	2/20
SCHEMBL29823077	0.43	2/20
SCHEMBL18050887	0.36	2/20
SCHEMBL5655435	0.36	2/20
SCHEMBL15170127	0.66	1/20
SCHEMBL24476374	0.43	1/20
SCHEMBL28654978	0.43	1/20
SCHEMBL15483956	0.42	1/20
SCHEMBL10469109	0.40	1/20
SCHEMBL8112211	0.40	1/20

Clinical trials — most relevant to AMPD1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Metformin Induces a Dietary Restriction-like State in Human	PHASE4	UNKNOWN
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity	PHASE4	COMPLETED
Genomic Outcomes of Metformin	PHASE4	COMPLETED
Metformin Use to Reduce Disparities in Newly Diagnosed Breast Cancer	PHASE4	WITHDRAWN
Acelarin First Line Randomised Pancreatic Study	PHASE2/PHASE3	SUSPENDED
Vitamin D Status in Patients With Severe Sepsis	PHASE3	WITHDRAWN
Effects of Vitamin B3 in Patients With Ataxia Telangiectasia	PHASE2	COMPLETED
Metformin for Fibromyalgia Symptoms (INFORM Trial)	PHASE2	RECRUITING
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals	PHASE1/PHASE2	COMPLETED
Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia	PHASE1/PHASE2	COMPLETED
University of California, San Diego (UCSD) Suramin Autism Treatment-1 (SAT1) Trial	PHASE1/PHASE2	COMPLETED
Reverse Transcriptase Inhibitors in AGS	PHASE2	COMPLETED
The AMPK Modulator Metformin as a Novel Adjunct to Conventional Therapy in Rheumatoid Arthritis Patients	PHASE1/PHASE2	COMPLETED
AMP-224, a PD-1 Inhibitor, With Stereotactic Body Radiation Therapy in Metastatic Colorectal Cancer	PHASE1	COMPLETED
Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism.	PHASE1	COMPLETED
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer	EARLY_PHASE1	COMPLETED
Effects of Pimecrolimus on Skin Biopsy Ex-plants From Patients With Atopic Dermatitis	nan	COMPLETED
ADAR1 Expression Level in Rectal Cancer	nan	RECRUITING
Effect of Polymorphisms in the Adenosine a2a Receptor Gene and AMPD2 Gene on Adenosine-Induced Vasodilation and Reactive Hyperemia	nan	COMPLETED
Evaluation of Adenosine Deaminase (ADA) Enzyme Deficiency in Patients With Lymphopenia and/or Elevated Immunoglobulin E	nan	UNKNOWN
Epigenetics, DNA Methylation Patterns and Periodontal Disease	nan	COMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Observational Study Evaluating the Prevalence of Enzyme Deficiency in Pulmonology Clinics (ADA)	nan	UNKNOWN
Study of Selected X-Linked Disorders: Aicardi Syndrome	nan	RECRUITING
Prevalence of Adenosine Deaminase (ADA) Enzyme Deficiency Disease in Adult Patients With Pulmonary Alveolar Proteinosis	nan	UNKNOWN
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart	nan	UNKNOWN
Effect of Age on Glucose and Lipid Metabolism	nan	COMPLETED
Evaluation the Topical Apremilast Nanoformulation in Treatment of Localized Plaque Psoriasis	nan	NOT_YET_RECRUITING
The Effect of White Tea Consumption on Obesity	nan	COMPLETED
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a AMPD1 binder may also engage these)

Protein	Name	Similarity
P10759	—	1.000	P10759 →
O08739	—	1.000	O08739 →
Q3V1D3	—	1.000	Q3V1D3 →
O09178	—	1.000	O09178 →
AMPD3	AMP deaminase 3	1.000	landscape →
Q54DD0	—	0.997	Q54DD0 →
AMPD2	AMP deaminase 2	0.995	landscape →
Q9DBT5	—	0.994	Q9DBT5 →
Q5XHF8	—	0.994	Q5XHF8 →
F4J8C6	—	0.993	F4J8C6 →
Q84NP7	—	0.993	Q84NP7 →
O80452	—	0.993	O80452 →
P50998	—	0.992	P50998 →
Q84WW3	—	0.992	Q84WW3 →
Q6ZQB6	—	0.992	Q6ZQB6 →
P09810	—	0.992	P09810 →
PPIP5K2	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	0.991	landscape →
Q02356	—	0.991	Q02356 →
Q9VR59	—	0.991	Q9VR59 →
P17290	—	0.990	P17290 →
P15274	—	0.990	P15274 →
Q9HBG4	—	0.990	Q9HBG4 →
Q9STV0	—	0.990	Q9STV0 →
TPH1	Tryptophan 5-hydroxylase 1	0.990	landscape →
Q8CFQ3	—	0.990	Q8CFQ3 →
Q2HZ26	—	0.990	Q2HZ26 →
Q8VCB3	—	0.989	Q8VCB3 →
Q8MJ26	—	0.989	Q8MJ26 →
Q0EAB8	—	0.989	Q0EAB8 →
P11982	—	0.989	P11982 →