ATP4B

Potassium-transporting ATPase subunit beta (G · P51164 · ATP4B on Sugi Atlas →

25,494 patent compounds predicted against ATP4B, 11,575 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Bromide (SCHEMBL825891)	1.00	20/20
SCHEMBL729163	0.58	20/20
SCHEMBL823907	1.00	19/20
Hydrochloric Acid (SCHEMBL826477)	1.00	19/20
Bromide (SCHEMBL825847)	0.97	19/20
Hydrochloric Acid (SCHEMBL827560)	0.91	19/20
Hydrochloric Acid (SCHEMBL826833)	0.75	19/20
Bromide (SCHEMBL826782)	0.69	19/20
Bromide (SCHEMBL826966)	0.68	19/20
Bromide (SCHEMBL826037)	0.67	19/20
Bromide (SCHEMBL826017)	1.00	18/20
Bromide (SCHEMBL826537)	1.00	18/20
Bromide (SCHEMBL827268)	1.00	18/20
Bromide (SCHEMBL826517)	0.73	18/20
Bromide (SCHEMBL826740)	0.73	18/20
Bromide (SCHEMBL826727)	0.72	18/20
Bromide (SCHEMBL826907)	0.72	18/20
Bromide (SCHEMBL827200)	0.70	18/20
Hydrochloric Acid (SCHEMBL827736)	0.68	18/20
Hydrochloric Acid (SCHEMBL826973)	0.66	18/20

Clinical trials — most relevant to ATP4B by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Switching From Insulin to Sulfonylurea in Diabetes Associated With Variants in MODY Genes	PHASE4	UNKNOWN
The Possible Efficacy and Safety of Lansoprazole Co-administration With Neoadjuvant Chemotherapy in Women With Breast Cancer	PHASE3	COMPLETED
PHOspholamban RElated CArdiomyopathy STudy - Intervention	PHASE3	COMPLETED
Applying Proton Pump Inhibitor to Prevent and Treat Acute Fluctuating Hearing Loss in Patients With SLC26A4 Mutation	PHASE2/PHASE3	UNKNOWN
Renal Transplantation and Inhaled Anesthetic Sevoflurane (SEVOREIN)	PHASE3	COMPLETED
Glibentek in Patients With Neonatal Diabetes Secondary to Mutations in K+-ATP Channels	PHASE3	COMPLETED
Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor	PHASE2	COMPLETED
Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial)	PHASE2	RECRUITING
Copper Histidine Therapy for Menkes Diseases	PHASE1/PHASE2	COMPLETED
Influence of Ethnicity and ABCB1 Gene Polymorphism on the Pharmacokinetics of Azithromycin in Healthy Bangladeshi Volunteers	PHASE1	UNKNOWN
Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis	EARLY_PHASE1	RECRUITING
Natural History Study of ATP1A3-related Disease	nan	UNKNOWN
Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome	nan	RECRUITING
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension	nan	UNKNOWN
Regulation of KATP Channels and Na+/K+ ATPase in Relation to Fatigue Development	nan	COMPLETED
Progressive Familial Intrahepatic Cholestasis in Indian Children - Establishing an Indian PFIC Registry	nan	UNKNOWN
Hydroxychloroquin (HCQ) in chILD of Genetic Defect	nan	COMPLETED
Sodium Transport: Genetics and Hypertension	nan	COMPLETED
Role for Biochemical Assays and Kayser-Fleischer Rings in Diagnosis of Wilson Disease	nan	RECRUITING
the Effect of ABCC2 Genetic Polymorphism on Neurotoxicity in Gastrointestinal Cancer Patients Receiving Oxaliplatin	nan	UNKNOWN
Coproporphyrine Isomers and Methotrexate Elimination	nan	COMPLETED
Genetic and Environmental Determinants of Hypertension	nan	COMPLETED
Pediatric Cardiomyopathy Mutation Analysis	nan	RECRUITING
Genetic Causes and Clinical Features of Childhood Interstitial Lung Diseases in China	nan	COMPLETED
Prescreening Study to Identify Potential Wilson Disease Participants for Gene-Editing Clinical Trial	nan	ACTIVE_NOT_RECRUITING
Prevalence and Risk Factors of Nephrocalcinosis in Children at Sohag University Hospital	nan	UNKNOWN
Pharmacogenetics Study in Taiwan's Ethnic Groups	nan	COMPLETED
Establishment of Human Cellular Disease Models for Wilson Disease	nan	COMPLETED
Heart and Skeletal Muscle Problems in Neuroacanthocytosis	nan	COMPLETED
Multidrug Resistance Genes in Patients With Acute Myeloid Leukemia	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a ATP4B binder may also engage these)

Protein	Name	Similarity
P18597	—	1.000	P18597 →
P18434	—	1.000	P18434 →
P50992	—	1.000	P50992 →
P18598	—	1.000	P18598 →
P33704	—	1.000	P33704 →
Q202B1	—	0.998	Q202B1 →
Q9GLC3	—	0.995	Q9GLC3 →
Q63377	—	0.995	Q63377 →
P30715	—	0.994	P30715 →
ATP1B3	Sodium/potassium-transporting ATPase subunit beta-3	0.994	landscape →
P97370	—	0.993	P97370 →
Q3T0C6	—	0.993	Q3T0C6 →
P51165	—	0.992	P51165 →
P05029	—	0.992	P05029 →
P43002	—	0.991	P43002 →
P25169	—	0.990	P25169 →
Q60489	—	0.989	Q60489 →
P33879	—	0.989	P33879 →
Q9UN42	—	0.987	Q9UN42 →
A7MB71	—	0.986	A7MB71 →
P21188	—	0.986	P21188 →
P30716	—	0.986	P30716 →
Q99ME6	—	0.986	Q99ME6 →
Q9BDK6	—	0.986	Q9BDK6 →
Q24046	—	0.985	Q24046 →
Q9I9C3	—	0.985	Q9I9C3 →
Q93235	—	0.984	Q93235 →
Q9XUY5	—	0.984	Q9XUY5 →
P2RX5	P2X purinoceptor 5	0.984	landscape →
P51579	—	0.983	P51579 →