ATP1B3

Sodium/potassium-transporting ATPase subunit beta-3 · P54709 · ATP1B3 on Sugi Atlas →

17,660 patent compounds predicted against ATP1B3, 10,167 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Metildigoxin (SCHEMBL43349)	0.89	16/20
Digoxin (SCHEMBL20506)	1.00	15/20
Digoxin (SCHEMBL126382)	1.00	15/20
Digoxin (SCHEMBL428012)	1.00	15/20
Digoxin (SCHEMBL597821)	0.94	15/20
Digoxin (SCHEMBL1559560)	0.94	15/20
Digoxin (SCHEMBL1584137)	0.93	15/20
Digoxin (SCHEMBL1461589)	0.58	15/20
SCHEMBL475105	0.51	15/20
SCHEMBL475107	0.51	15/20
Digoxin (SCHEMBL1830809)	0.91	14/20
SCHEMBL1302063	0.85	14/20
SCHEMBL1484406	0.65	14/20
Deslanoside (SCHEMBL125311)	0.80	13/20
Deslanoside (SCHEMBL125312)	0.80	13/20
SCHEMBL1483332	0.74	13/20
SCHEMBL1483335	0.74	13/20
Uzarin (SCHEMBL702463)	0.92	12/20
Digitoxigenin Gentiobioside (SCHEMBL702464)	0.92	12/20
Digitoxigenin Gentiobioside (SCHEMBL1652279)	0.92	12/20

Clinical trials — most relevant to ATP1B3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Sulphonylurea Receptor Mutation and Responsiveness to Gliclazide - a Pilot Proof of Concept, Randomised Cross-over Study	PHASE4	COMPLETED
Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR)	PHASE4	UNKNOWN
Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor	PHASE2	COMPLETED
Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial)	PHASE2	RECRUITING
Pilot Study, Comparative, Single-center, Randomized, Crossover, Double-blind, Against Placebo, Testing the Effectiveness of Triheptanoin Oil in Alternating Hemiplegia of Childhood	PHASE2	COMPLETED
Natural History Study of ATP1A3-related Disease	nan	UNKNOWN
Sodium Transport: Genetics and Hypertension	nan	COMPLETED
Bile Acids Metabolism and Genetic Mutation Profile in the Intrahepatic Cholestasis of Pregnacy in Indian Population	nan	RECRUITING
Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome	nan	RECRUITING
Sodium Accumulation Study in Haemodialysis: Brain Study	nan	RECRUITING
Genetic and Environmental Determinants of Hypertension	nan	COMPLETED
Hydroxychloroquin (HCQ) in chILD of Genetic Defect	nan	COMPLETED
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives	nan	UNKNOWN
Coproporphyrine Isomers and Methotrexate Elimination	nan	COMPLETED
The Role of Biomarkers in Inherited Cardiac Conditions	nan	WITHDRAWN
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension	nan	UNKNOWN
Pediatric Cardiomyopathy Mutation Analysis	nan	RECRUITING
Heart and Skeletal Muscle Problems in Neuroacanthocytosis	nan	COMPLETED
Prevalence and Risk Factors of Nephrocalcinosis in Children at Sohag University Hospital	nan	UNKNOWN
Phenotypic and Genotypic Studies in Congenital and Early Onset Ataxias	nan	COMPLETED
Double Blind Crossover Comparison of Diuretics in the Young	nan	UNKNOWN
Genetic Causes and Clinical Features of Childhood Interstitial Lung Diseases in China	nan	COMPLETED
Specificities of Atypical Non AutoImmune Diabetes (ANAID) in the French West Indies	nan	NOT_YET_RECRUITING
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts	nan	COMPLETED
Artificial Intelligence for the Prioritization of Genetic Background in Brugada Syndrome	nan	COMPLETED
Multidrug Resistance Genes in Patients With Acute Myeloid Leukemia	nan	ACTIVE_NOT_RECRUITING
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients.	nan	UNKNOWN
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED
Genetic Testing in Detection of Late-Onset Hearing Loss	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ATP1B3 binder may also engage these)

Protein	Name	Similarity
Q63377	—	1.000	Q63377 →
Q9GLC3	—	1.000	Q9GLC3 →
Q3T0C6	—	1.000	Q3T0C6 →
Q60489	—	1.000	Q60489 →
P97370	—	1.000	P97370 →
Q202B1	—	0.998	Q202B1 →
P30715	—	0.997	P30715 →
P25169	—	0.996	P25169 →
P30716	—	0.996	P30716 →
P18597	—	0.995	P18597 →
P33879	—	0.995	P33879 →
P05029	—	0.995	P05029 →
ATP4B	Potassium-transporting ATPase subunit beta (G	0.994	landscape →
Q93235	—	0.993	Q93235 →
P18598	—	0.992	P18598 →
P43002	—	0.992	P43002 →
Q9XUY5	—	0.992	Q9XUY5 →
P21188	—	0.992	P21188 →
P50992	—	0.992	P50992 →
P33704	—	0.991	P33704 →
P18434	—	0.990	P18434 →
P51165	—	0.990	P51165 →
A8X4W9	—	0.989	A8X4W9 →
P2RX3	P2X purinoceptor 3	0.989	landscape →
Q24046	—	0.988	Q24046 →
Q9BDK6	—	0.986	Q9BDK6 →
Q99ME6	—	0.986	Q99ME6 →
Q9I9C3	—	0.986	Q9I9C3 →
Q9UN42	—	0.986	Q9UN42 →
Q3UR32	—	0.985	Q3UR32 →