BAG2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Molibresib (SCHEMBL1872390)	1.00	1/20
Molibresib (SCHEMBL12671490)	1.00	1/20
Molibresib (SCHEMBL12966358)	1.00	1/20
SCHEMBL9998851	0.91	1/20
SCHEMBL14756282	0.88	1/20
SCHEMBL15980874	0.88	1/20
SCHEMBL12966165	0.87	1/20
SCHEMBL14756215	0.87	1/20
SCHEMBL14756339	0.87	1/20
SCHEMBL15980861	0.87	1/20
SCHEMBL9998825	0.86	1/20
SCHEMBL15980893	0.86	1/20
SCHEMBL15980803	0.86	1/20
SCHEMBL1874116	0.85	1/20
SCHEMBL12671221	0.85	1/20
SCHEMBL14756021	0.85	1/20
SCHEMBL14756240	0.85	1/20
SCHEMBL14756287	0.85	1/20
SCHEMBL14756335	0.85	1/20
SCHEMBL14756409	0.85	1/20

Clinical trials — most relevant to BAG2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Targeting Endoplasmic Reticulum Stress in Human Hypertension	PHASE1/PHASE2	RECRUITING
ALXN2350 in Adult Participants With BAG3-Associated Dilated Cardiomyopathy	PHASE1/PHASE2	RECRUITING
Efficacy and Safety Assessment of Oral LBH589 in Adult Patients With Advanced Soft TIssue Sarcoma After Pre-treatment Failure	PHASE2	COMPLETED
Belimumab Treatment of Emphysema Patients With Anti-GRP78 Autoantibodies	PHASE2	COMPLETED
Targeting the Tumor Microenvironment in R/M SCCHN	PHASE1/PHASE2	UNKNOWN
Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacement Therapy	PHASE2	COMPLETED
A Phase 2 Study to Investigate the Clinical Activity of IPI-504 in Patients With Hormone-resistant Prostate Cancer	PHASE2	COMPLETED
OGX-427 in Castration Resistant Prostate Cancer Patients	PHASE2	COMPLETED
Study of Oral CNF2024 (BIIB021) in Advanced Solid Tumors	PHASE1	COMPLETED
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors	PHASE1	COMPLETED
SNX-5422 to Treat Solid Tumor Cancers and Lymphomas	PHASE1	COMPLETED
Safety Study of IPI-504 in Patients With Relapsed and Relapsed Refractory Multiple Myeloma	PHASE1	COMPLETED
Safety and Pharmacology Study of SNX-5422 in Subjects With Resistant Lung Adenocarcinoma	PHASE1	COMPLETED
A Phase 1 AAV Gene Therapy Trial Evaluating Safety and Preliminary Efficacy of RP-A701 in Subjects With BAG3 Dilated Cardiomyopathy	PHASE1	RECRUITING
A Study About the Natural History in Adults With BAG3 Dilated Cardiomyopathy (a Type of Heart Disease) (BAG3 DCM)	nan	ACTIVE_NOT_RECRUITING
Establishment of Human Cellular Disease Models for Wilson Disease	nan	COMPLETED
Observational Study of Natural History of BAG3 Gene Mutation-Associated Dilated Cardiomyopathy in Chinese Adults	nan	NOT_YET_RECRUITING
BAG3-DCM Natural History Study	nan	NOT_YET_RECRUITING
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)	nan	RECRUITING
LncRNA Nicotinamide Nucleotide Transhydrogenase-Antisense RNA1 NNT-AS1 in CRC	nan	COMPLETED
Exercise on Expression of Heat Shock Protein 70 in Arterial Risk	nan	COMPLETED
Perfusion-Induced Hyperthermia for Metastatic Carcinoma	nan	COMPLETED
Possible Diagnostic Protein Markers in Schistosoma Related Bladder Diseases.	nan	NOT_YET_RECRUITING
Efficacy of Solarplast for Health and Oxidative Stress	nan	COMPLETED
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Acute Passive Heating in Healthy Older Adults	nan	COMPLETED
Proteomic Analysis of Serum Samples After Cardiac Arrest: a TTM-trial Substudy	nan	ACTIVE_NOT_RECRUITING
Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure	nan	COMPLETED
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia	nan	RECRUITING
The Role of HSP90 in Peripheral Vascular Lesions of Diabetic Atherosclerosis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a BAG2 binder may also engage these)

Protein	Name	Similarity
Q91YN9	—	1.000	Q91YN9 →
Q3ZBG5	—	1.000	Q3ZBG5 →
Q9CR81	—	0.997	Q9CR81 →
Q9ENZ3	—	0.994	Q9ENZ3 →
P03511	—	0.994	P03511 →
F4IJK1	—	0.994	F4IJK1 →
Q6P566	—	0.994	Q6P566 →
Q9ENX7	—	0.994	Q9ENX7 →
Q8IR45	—	0.993	Q8IR45 →
P69267	—	0.993	P69267 →
Q0KI28	—	0.993	Q0KI28 →
Q8UVV7	—	0.992	Q8UVV7 →
Q9P7K2	—	0.992	Q9P7K2 →
Q1T763	—	0.992	Q1T763 →
Q9BW66	—	0.992	Q9BW66 →
Q24JY8	—	0.992	Q24JY8 →
Q6CQ94	—	0.992	Q6CQ94 →
Q9SQR5	—	0.992	Q9SQR5 →
Q9SXA1	—	0.992	Q9SXA1 →
P33493	—	0.992	P33493 →
P03506	—	0.992	P03506 →
Q9CA89	—	0.991	Q9CA89 →
P08273	—	0.991	P08273 →
Q10006	—	0.991	Q10006 →
Q67402	—	0.991	Q67402 →
Q9LZN0	—	0.991	Q9LZN0 →
O48767	—	0.991	O48767 →
P0C139	—	0.991	P0C139 →
O14299	—	0.991	O14299 →
Q5I0J4	—	0.991	Q5I0J4 →