CASK

Peripheral plasma membrane protein CASK · O14936 · CASK on Sugi Atlas →

9,991 patent compounds predicted against CASK, 8,049 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Pha-665752 (SCHEMBL93654)	1.00	1/20
Pha-665752 (SCHEMBL93655)	1.00	1/20
Pha-665752 (SCHEMBL93656)	1.00	1/20
Pha-665752 (SCHEMBL93657)	1.00	1/20
Ruxolitinib (SCHEMBL99225)	1.00	1/20
Ruxolitinib (SCHEMBL101279)	1.00	1/20
Pha-665752 (SCHEMBL140412)	1.00	1/20
Bosutinib (SCHEMBL158390)	1.00	1/20
Ruxolitinib (SCHEMBL171319)	1.00	1/20
Bms-387032 (SCHEMBL187401)	1.00	1/20
Fedratinib (SCHEMBL263741)	1.00	1/20
SCHEMBL99245	0.98	1/20
SCHEMBL99371	0.98	1/20
SCHEMBL103135	0.98	1/20
SCHEMBL143795	0.93	1/20
SCHEMBL98692	0.92	1/20
SCHEMBL145952	0.88	1/20
SCHEMBL144319	0.88	1/20
SCHEMBL146729	0.88	1/20
SCHEMBL144256	0.88	1/20

Clinical trials — most relevant to CASK by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Study of Efficacy and Safety of REGPARA Drug in Dialysis Patients Have High Blood Levels of Parathyroid	PHASE4	COMPLETED
The Effect of the Preoperative Oral Carbohydrate Attenuating Immediate Postoperative Insulin Resistance on PI3K Dependent Signaling Pathway	PHASE4	COMPLETED
Efficacy and Safety of Azilsartan in Subjects With Essential Hypertension	PHASE2	COMPLETED
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
Palliative Thoracic Radiotherapy Plus BKM120	PHASE1	COMPLETED
Effect of Cinacalcet on Parathyroid Hormone Secretion in Children and Adolescents With Hypophosphatemic Rickets	PHASE1	COMPLETED
Parathyroid Hormone (PTH) Homeostasis in Bartter Syndrome	nan	UNKNOWN
A Retrospective Study to Determine the Incidence of NTRK Fusions. NTRK Study	nan	COMPLETED
Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA)	nan	UNKNOWN
Hypoparathyroidism in Denmark	nan	COMPLETED
Lipid and Glycogen Metabolism in Patients With Impaired Glucose Tolerance and Calcium Sensing Receptor Mutations	nan	UNKNOWN
Role of Nitric Oxide in Diabetic Patients With Erectile Dysfunction	nan	COMPLETED
T1D Risk Assessment in Kids With Relatives	nan	COMPLETED
The Changes of Cytokines in Guillain Barré Syndrome: the Correlation With Clinical Manifestations and Skin Innervation	nan	UNKNOWN
Wolfram Syndrome and WFS1-related Disorders International Registry and Clinical Study	nan	RECRUITING
Is There Association Between Vitamin D Levels And Insulin Resistance In Polycystic Ovary Syndrome?	nan	UNKNOWN
NGF, TrKA,p75NTR in Men With ED and Diabetes With or Without MS	nan	UNKNOWN
Depressed AIRE Gene Expression Causes Immune Cell Dysfunction & Autoimmunity in Down Syndrome	nan	COMPLETED
Defective Atypical Protein Kinase C (PKC) Activation in Diabetes and Metabolic Syndrome	nan	COMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Regulation of Vitamin D Receptor (VDR),Calcium Sensing Receptor (CaSR), Cyclin D1,Ki67 and Proliferating Cell Nuclear Antigen (PCNA) in Primary Hyperparathyroidism	nan	UNKNOWN
Leukocyte Morphological Parameters as Prognostic Markers in CAP	nan	UNKNOWN
Novel Biomarkers in Inflammatory Bowel Disease	nan	COMPLETED
Tilt Table With Suspected Postural Orthostatic Tachycardia Syndrome (POTS) Subjects	nan	COMPLETED
Pompe & Pain - Study to Assess Nociceptive Pain in Adult Patients With Pompe Disease	nan	UNKNOWN
New Transporting Solution in Parathyroid Allotransplantation	nan	UNKNOWN
Cardiovascular, Renal, and Skeletal Complications in Patients With Post-Surgical Hypoparathyroidism	nan	COMPLETED
A Retro-/Prospective, Non-interventional, Cohort Study in Adult Patients With Locally Advanced or Metastatic Tumors With a Neurotrophic Tyrosine Receptor Kinase (NTRK) Gene Fusion, Treated With Larotrectinib	nan	COMPLETED
Poor Sleep and Inflammation in HIV-Infected Adults	nan	COMPLETED
Changes in Skin Innervation of Neurologically Asymptomatic Type 2 Diabetic Patients: the Correlation With the Diabetic Parameters and Neurotrophins.	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a CASK binder may also engage these)

Protein	Name	Similarity
Q62915	—	1.000	Q62915 →
O70589	—	1.000	O70589 →
Q00013	—	0.997	Q00013 →
P13678	—	0.992	P13678 →
Q5ZJ00	—	0.991	Q5ZJ00 →
G5ECY0	—	0.991	G5ECY0 →
P54936	—	0.990	P54936 →
Q24210	—	0.989	Q24210 →
Q03145	—	0.989	Q03145 →
Q16975	—	0.989	Q16975 →
Q90344	—	0.989	Q90344 →
Q95266	—	0.989	Q95266 →
P49697	—	0.989	P49697 →
Q91735	—	0.988	Q91735 →
Q7SY49	—	0.988	Q7SY49 →
Q5PU49	—	0.988	Q5PU49 →
Q96JB8	—	0.988	Q96JB8 →
Q9WVK4	—	0.988	Q9WVK4 →
Q6PHZ2	—	0.987	Q6PHZ2 →
Q91YL3	—	0.987	Q91YL3 →
Q09137	—	0.987	Q09137 →
Q9NHV9	—	0.987	Q9NHV9 →
EPHA5	Ephrin type-A receptor 5	0.987	landscape →
Q5E9R3	—	0.987	Q5E9R3 →
Q9NWZ5	—	0.987	Q9NWZ5 →
O42422	—	0.987	O42422 →
Q02111	—	0.987	Q02111 →
P08487	—	0.987	P08487 →
Q9QVP9	—	0.987	Q9QVP9 →
PAK2	Serine/threonine-protein kinase PAK 2	0.986	landscape →