Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | HPGD | P15428 | 4/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 4/20 | 1.00 |
| ▸ | HTT | P42858 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | PTPN7 | P35236 | 2/20 | 1.00 |
| ▸ | RAB9A | P51151 | 4/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.71 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.71 |
| ▸ | MITF | O75030 | 1/20 | 0.71 |
| ▸ | CATSPER1 | Q8NEC5 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.46 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11605100 | 0.79 | NPC1 (0.71) | ALDH1A1MAPTHPGDMAPK1HTT | |
| SCHEMBL14948955 | 0.78 | CATSPER1 (0.82) | ALDH1A1MAPTHPGDMAPK1HTT | |
| SCHEMBL12378791 | 0.76 | LMNA (0.60) | ALDH1A1MAPTHPGDMAPK1HTT | |
| SCHEMBL8251473 | 0.73 | MAPT (0.62) | ALDH1A1MAPTHPGDMAPK1HTT | |
| SCHEMBL13825277 | 0.71 | MAPT (0.55) | ALDH1A1MAPTHPGDMAPK1HTT | |
| SCHEMBL9418310 | 0.71 | RXFP1 (0.79) | ALDH1A1MAPTHPGDMAPK1LMNA | |
| SCHEMBL51509 | 0.71 | RXFP1 (0.79) | ALDH1A1MAPTHPGDMAPK1LMNA | |
| SCHEMBL8372387 | 0.70 | ALDH1A1 (0.58) | ALDH1A1MAPTHPGDMAPK1HTT | |
| SCHEMBL20931096 | 0.68 | CES2 (0.68) | MAPTHPGDMAPK1LMNARAB9A | |
| Ethyne SCHEMBL8195983 | 0.67 | RXFP1 (0.73) | ALDH1A1MAPTHPGDMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105240-A1 | Methods for treating leukemia and myelodysplastic syndrome, and methods for identifying agents for treating same | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2009-04-23 | — | — | US | claimed |
| US-11129835-B2 | Methods and compositions for the inhibition of PIN1 | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2021-09-28 | — | — | US | disclosed |
| US-20200093832-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. | 2020-03-26 | — | — | US | disclosed |
| US-20180153934-A1 | ARSENIC TRIOXIDE FOR TREATMENT OF PIN1-ASSOCIATED DISORDERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-06-07 | — | — | US | disclosed |
| US-20170304310-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-10-26 | — | — | US | disclosed |
| US-9730941-B2 | Methods and compositions for the inhibition of Pin1 | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2017-08-15 | — | — | US | disclosed |
| US-9091692-B2 | Fluorescent dye | SHINICHIRO ISOBE (JP) | 2015-07-28 | — | — | US | disclosed |
| US-20150133442-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-05-14 | — | — | US | disclosed |
| US-20140206872-A1 | FLUORESCENT DYE | SHINICHIRO ISOBE (JP) | 2014-07-24 | — | — | US | disclosed |
| US-20120308792-A1 | RED FLUORESCENCE CONVERSION COMPOSITION AND RED FLUORESCENCE CONVERSION FILM | SHARP CORPORATION (JP) | 2012-12-06 | — | — | US | disclosed |
| US-8304259-B2 | Labeling dye for detecting biomolecule, labeling kit, and method for detecting biomolecule | Isobe, Shinichiro (JP) | 2012-11-06 | — | — | US | disclosed |
| US-20120095032-A1 | METHODS FOR TREATING LEUKEMIA AND MYELODYSPLASTIC SYNDROME, AND METHODS FOR IDENTIFYING AGENTS FOR TREATING SAME | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2012-04-19 | — | — | US | disclosed |
| US-20120095032-A1 | METHODS FOR TREATING LEUKEMIA AND MYELODYSPLASTIC SYNDROME, AND METHODS FOR IDENTIFYING AGENTS FOR TREATING SAME | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2012-04-19 | — | — | US | disclosed |
| US-20110195408-A1 | Labeling Dye for Detecting Biomolecule, Labeling Kit, and Method for Detecting Biomolecule | ISOBE, SHINICHIRO (JP) | 2011-08-11 | — | — | US | disclosed |
| US-7662555-B2 | Method for detecting biomolecule, labeling dye used therefore, and labeling kit | ISOBE SHINICHIRO | 2010-02-16 | — | — | US | disclosed |
| US-20090105240-A1 | Methods for treating leukemia and myelodysplastic syndrome, and methods for identifying agents for treating same | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2009-04-23 | — | — | US | disclosed |
| US-20090105240-A1 | Methods for treating leukemia and myelodysplastic syndrome, and methods for identifying agents for treating same | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2009-04-23 | — | — | US | disclosed |
| US-20070154890-A1 | Method for detecting biomolecule, labeling dye used therefore, and labeling kit | ISOBE SHINICHIRO | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110195408-A1 | Labeling Dye for Detecting Biomolecule, Labeling Kit, and Method for Detecting Biomolecule | EPCAM, MB, MKI67 | ALDH1A1 452/4885MAPT 3120/4885HPGD 2708/4885 |
| US-20090105240-A1 | Methods for treating leukemia and myelodysplastic syndrome, and methods for identifying agents for treating same | MCL1, AS3MT, MYADM | ALDH1A1 210/4885MAPT 4723/4885HPGD 547/4885 |
| US-20070154890-A1 | Method for detecting biomolecule, labeling dye used therefore, and labeling kit | EPCAM, MB, NEFM | ALDH1A1 855/4885MAPT 2096/4885HPGD 3179/4885 |
| US-20200093832-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | PIN1, FKBP1A, FKBP2 | ALDH1A1 4586/4885MAPT 143/4885HPGD 3085/4885 |
| US-20180153934-A1 | ARSENIC TRIOXIDE FOR TREATMENT OF PIN1-ASSOCIATED DISORDERS | PIN1, AS3MT, PML | ALDH1A1 2657/4885MAPT 1149/4885HPGD 2497/4885 |
| US-20140206872-A1 | FLUORESCENT DYE | MB, NCL, NEFM | ALDH1A1 3240/4885MAPT 858/4885HPGD 2042/4885 |
| US-20150133442-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | PIN1, FKBP1A, FKBP2 | ALDH1A1 4586/4885MAPT 143/4885HPGD 3085/4885 |
| US-20170304310-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | PIN1, FKBP1A, FKBP2 | ALDH1A1 4586/4885MAPT 143/4885HPGD 3085/4885 |
| US-20120095032-A1 | METHODS FOR TREATING LEUKEMIA AND MYELODYSPLASTIC SYNDROME, AND METHODS FOR IDENTIFYING AGENTS FOR TREATING SAME | MCL1, AS3MT, MYADM | ALDH1A1 210/4885MAPT 4723/4885HPGD 547/4885 |
| US-11129835-B2 | Methods and compositions for the inhibition of PIN1 | PIN1, FKBP1A, FKBP2 | ALDH1A1 4586/4885MAPT 143/4885HPGD 3085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.