COG4

Conserved oligomeric Golgi complex subunit 4 · Q9H9E3 · COG4 on Sugi Atlas →

0 patent compounds predicted against COG4, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to COG4 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD PHASE3COMPLETED
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) PHASE1/PHASE2NOT_YET_RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacement Therapy PHASE2COMPLETED
Pembrolizumab Plus Enfortumab Vedotin in Collecting Duct and Renal Medullary Carcinoma PHASE2RECRUITING
Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy PHASE1COMPLETED
The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism EARLY_PHASE1UNKNOWN
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM) nanCOMPLETED
Identification of New FTLD Genes nanUNKNOWN
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study) nanCOMPLETED
Susceptibility Genes in Autism Spectrum Disorders nanCOMPLETED
A Study to Learn How Stargardt-type Eye Conditions Progress in Children and Adults nanRECRUITING
McArdle Disease Treatment by Ketogenic Diet nanCOMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN) nanRECRUITING
Use of miRNAs in Growth Hormone Deficiency (GHD) nanUNKNOWN
Genetic Analysis of Hereditary Disorders of Hearing and Balance nanCOMPLETED
Registry Gangliosidoses nanUNKNOWN
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia nanUNKNOWN
Pediatric Evaluation and Registry for Liver Cholestasis in Canada nanRECRUITING
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Immunological Profile and Clinical Characteristics of Children Diagnosed With Chronic Granulomatous Disease nanUNKNOWN
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease nanRECRUITING
Signs and Symptoms of Genetic Abnormalities Linked to Inherited Heart Disease nanCOMPLETED
Natural History Study of GEMIN-5 Related Neurodevelopmental Disorder nanRECRUITING
Genetic Studies of Lysosomal Storage Disorders nanENROLLING_BY_INVITATION
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing nanCOMPLETED
Open-Label Study of Omega 3 Oil Supplementation for Aging-Related Cognitive Decline nanCOMPLETED
Role of Polymorphisms in the IL-1 Gene Cluster nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a COG4 binder may also engage these)

ProteinNameSimilarity
Q5R7R6 1.000 Q5R7R6 →
Q8R1U1 1.000 Q8R1U1 →
Q3MHG0 1.000 Q3MHG0 →
Q29RB1 0.994 Q29RB1 →
COG6 Conserved oligomeric Golgi complex subunit 6 0.987 landscape →
Q0WQF4 0.986 Q0WQF4 →
Q155U0 0.986 Q155U0 →
Q68FP9 0.985 Q68FP9 →
P97878 0.984 P97878 →
Q505L3 0.981 Q505L3 →
Q3SZI7 0.981 Q3SZI7 →
Q4V9Y0 0.980 Q4V9Y0 →
Q8R3I3 0.980 Q8R3I3 →
Q9D4H1 0.980 Q9D4H1 →
Q3TPX4 0.979 Q3TPX4 →
O00471 0.978 O00471 →
O54921 0.977 O54921 →
Q96KP1 0.976 Q96KP1 →
Q84K25 0.974 Q84K25 →
Q8CI04 0.973 Q8CI04 →
O54692 0.973 O54692 →
Q5TJF0 0.973 Q5TJF0 →
ZW10 Centromere/kinetochore protein zw10 homolog 0.972 landscape →
Q8L838 0.971 Q8L838 →
Q5SPW0 0.971 Q5SPW0 →
Q8N1B4 0.970 Q8N1B4 →
Q6NUQ1 0.970 Q6NUQ1 →
EXOC4 Exocyst complex component 4 0.970 landscape →
Q9JMK8 0.970 Q9JMK8 →
Q9LXX6 0.969 Q9LXX6 →