Sugi Predict

Sugi Predict / Targets / COG6

COG6

Conserved oligomeric Golgi complex subunit 6 · Q9Y2V7 · COG6 on Sugi Atlas →

0 patent compounds predicted against COG6, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to COG6 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) PHASE1/PHASE2NOT_YET_RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacement Therapy PHASE2COMPLETED
Reverse Transcriptase Inhibitors in AGS PHASE2COMPLETED
The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism EARLY_PHASE1UNKNOWN
PBA Use for Treatment of ATF6-/- Patients EARLY_PHASE1SUSPENDED
Phenotypic and Genotypic Studies in Congenital and Early Onset Ataxias nanCOMPLETED
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study) nanCOMPLETED
Investigations Into ISCU Myopathy or Iron Sulfur Scaffold U Protein Myopathy nanCOMPLETED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM) nanCOMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
In Vivo Metabolism of apoB-containing Lipoproteins in ANGPTL3 Deficient Subjects nanUNKNOWN
Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis nanCOMPLETED
Registry Gangliosidoses nanUNKNOWN
Hydroxychloroquin (HCQ) in chILD of Genetic Defect nanCOMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Genetic Analysis of Gray Platelet Syndrome nanCOMPLETED
Identification of New FTLD Genes nanUNKNOWN
Pediatric Evaluation and Registry for Liver Cholestasis in Canada nanRECRUITING
Biomarker Research in Inherited Movement Disorders nanRECRUITING
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
Protein Synthesis in the Brain of Patients With Fragile X Syndrome nanCOMPLETED
Evaluation of Systemic and Oral Conditions of Pregnant Women and Their Babies, With Exposure to COVID-19 Infection nanUNKNOWN
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy nanCOMPLETED
Identification of a New Gene Involved in Hereditary Lipodystrophy nanCOMPLETED
Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) nanCOMPLETED
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING
A Prospective Trial to Identify Biomarkers Involved in the Transition From Acute to Persistent Chronic Low Back Pain nanUNKNOWN
Role of Polymorphisms in the IL-1 Gene Cluster nanCOMPLETED
Genetic Characterization of Parkinson's Disease nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a COG6 binder may also engage these)

ProteinNameSimilarity
Q3SZI7 — 1.000 Q3SZI7 →
Q68FP9 — 1.000 Q68FP9 →
Q8R3I3 — 0.997 Q8R3I3 →
Q8R1U1 — 0.991 Q8R1U1 →
Q5R7R6 — 0.989 Q5R7R6 →
Q3MHG0 — 0.988 Q3MHG0 →
Q29RB1 — 0.987 Q29RB1 →
Q155U0 — 0.986 Q155U0 →
COG4 Conserved oligomeric Golgi complex subunit 4 0.986 landscape →
P97878 — 0.983 P97878 →
Q0WQF4 — 0.982 Q0WQF4 →
Q505L3 — 0.982 Q505L3 →
Q5TJF0 — 0.980 Q5TJF0 →
Q4V9Y0 — 0.980 Q4V9Y0 →
Q3TPX4 — 0.978 Q3TPX4 →
O00471 — 0.977 O00471 →
Q9D4H1 — 0.977 Q9D4H1 →
Q8N1B4 — 0.976 Q8N1B4 →
Q84K25 — 0.976 Q84K25 →
O54921 — 0.976 O54921 →
Q8CI04 — 0.975 Q8CI04 →
Q8C754 — 0.974 Q8C754 →
Q96KP1 — 0.974 Q96KP1 →
O55166 — 0.973 O55166 →
Q6GQ80 — 0.971 Q6GQ80 →
Q6A026 — 0.971 Q6A026 →
Q80YQ8 — 0.971 Q80YQ8 →
C0H906 — 0.970 C0H906 →
O54692 — 0.970 O54692 →
Q6GQD0 — 0.970 Q6GQD0 →