COG5

Conserved oligomeric Golgi complex subunit 5

0 patent compounds predicted against COG5, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Germline variants in COG5 on Sugi Variant → ClinVar classifications, population frequency, and predictor agreement (AlphaMissense, SaProt, REVEL) Full COG5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

Clinical trials — most relevant to COG5 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47)	PHASE1/PHASE2	NOT_YET_RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)	PHASE1/PHASE2	RECRUITING
NEO100 and High-Grade Meningioma	PHASE2	RECRUITING
The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism	EARLY_PHASE1	UNKNOWN
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D)	EARLY_PHASE1	COMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events	nan	COMPLETED
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
Natural History Study of GEMIN-5 Related Neurodevelopmental Disorder	nan	RECRUITING
Investigations Into ISCU Myopathy or Iron Sulfur Scaffold U Protein Myopathy	nan	COMPLETED
Genetic Analysis of Gray Platelet Syndrome	nan	COMPLETED
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia	nan	UNKNOWN
Pediatric Evaluation and Registry for Liver Cholestasis in Canada	nan	RECRUITING
Study of Proteus Syndrome and Related Congenital Disorders	nan	RECRUITING
Immunological Profile and Clinical Characteristics of Children Diagnosed With Chronic Granulomatous Disease	nan	UNKNOWN
Hydroxychloroquin (HCQ) in chILD of Genetic Defect	nan	COMPLETED
PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Changes in the Hepatobiliary System in Patients With Primary Biliary Cholangitis Before and After Treatment.	nan	ACTIVE_NOT_RECRUITING
Genetic Variations That Increase the Risk for Calcium Kidney Stones: a Family-based Study	nan	COMPLETED
Identification of New FTLD Genes	nan	UNKNOWN
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)	nan	COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise	nan	COMPLETED
Protein Synthesis in the Brain of Patients With Fragile X Syndrome	nan	COMPLETED
Molecular Genetic Study of Schizophrenia: Parent-Offspring Trios	nan	COMPLETED
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
Open-Label Study of Omega 3 Oil Supplementation for Aging-Related Cognitive Decline	nan	COMPLETED
Clinical, Cellular, and Molecular Investigation Into Oculocutaneous Albinism	nan	COMPLETED
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)	nan	RECRUITING
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a COG5 binder may also engage these)

Protein	Name	Similarity
Q8C0L8	—	1.000	Q8C0L8 →
F4JHH5	—	0.998	F4JHH5 →
Q6NMI3	—	0.998	Q6NMI3 →
Q9FGN0	—	0.997	Q9FGN0 →
COG7	Conserved oligomeric Golgi complex subunit 7	0.994	landscape →
F4HQ84	—	0.994	F4HQ84 →
O35250	—	0.993	O35250 →
F4JRR1	—	0.993	F4JRR1 →
Q9C9V9	—	0.992	Q9C9V9 →
Q3T1G7	—	0.992	Q3T1G7 →
Q9LXX6	—	0.991	Q9LXX6 →
Q9FFF3	—	0.991	Q9FFF3 →
O54922	—	0.990	O54922 →
Q29N70	—	0.990	Q29N70 →
Q8MSY4	—	0.990	Q8MSY4 →
Q1E6R9	—	0.990	Q1E6R9 →
Q19262	—	0.990	Q19262 →
E7FC72	—	0.990	E7FC72 →
P0DXK2	—	0.990	P0DXK2 →
Q95TN4	—	0.989	Q95TN4 →
COG2	Conserved oligomeric Golgi complex subunit 2	0.989	landscape →
A2VDR8	—	0.989	A2VDR8 →
Q5AZS0	—	0.989	Q5AZS0 →
Q9HE88	—	0.989	Q9HE88 →
Q8CI04	—	0.989	Q8CI04 →
Q16ZN9	—	0.989	Q16ZN9 →
Q9VNH6	—	0.989	Q9VNH6 →
Q0V8C2	—	0.988	Q0V8C2 →
Q0CSR3	—	0.988	Q0CSR3 →
Q5U247	—	0.988	Q5U247 →