Sugi Predict
/ Targets
/ COG5
Top predicted compounds (top 20 by supporting neighbours, then confidence)
| Compound | Confidence | Supporting neighbours |
|---|
Clinical trials — most relevant to COG5 by text similarity (a relevance ranking, not an exhaustive list)
| Trial | Phase | Status |
|---|
| Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) |
PHASE1/PHASE2 | NOT_YET_RECRUITING |
| Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) |
PHASE1/PHASE2 | RECRUITING |
| NEO100 and High-Grade Meningioma |
PHASE2 | RECRUITING |
| The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism |
EARLY_PHASE1 | UNKNOWN |
| Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D) |
EARLY_PHASE1 | COMPLETED |
| Study of the Pathophysiological Mechanisms Involved in Bleeding Events |
nan | COMPLETED |
| Autophagy in Systemic Lupus Erythematosus |
nan | UNKNOWN |
| Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM) |
nan | COMPLETED |
| MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study) |
nan | COMPLETED |
| Natural History Study of GEMIN-5 Related Neurodevelopmental Disorder |
nan | RECRUITING |
| Investigations Into ISCU Myopathy or Iron Sulfur Scaffold U Protein Myopathy |
nan | COMPLETED |
| Genetic Analysis of Gray Platelet Syndrome |
nan | COMPLETED |
| A Study on Risk Mutations of Vulnerability Genes of Schizophrenia |
nan | UNKNOWN |
| Pediatric Evaluation and Registry for Liver Cholestasis in Canada |
nan | RECRUITING |
| Study of Proteus Syndrome and Related Congenital Disorders |
nan | RECRUITING |
| Immunological Profile and Clinical Characteristics of Children Diagnosed With Chronic Granulomatous Disease |
nan | UNKNOWN |
| Hydroxychloroquin (HCQ) in chILD of Genetic Defect |
nan | COMPLETED |
| PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Changes in the Hepatobiliary System in Patients With Primary Biliary Cholangitis Before and After Treatment. |
nan | ACTIVE_NOT_RECRUITING |
| Genetic Variations That Increase the Risk for Calcium Kidney Stones: a Family-based Study |
nan | COMPLETED |
| Identification of New FTLD Genes |
nan | UNKNOWN |
| Genetic Characterization of Parkinson's Disease |
nan | COMPLETED |
| Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) |
nan | COMPLETED |
| Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise |
nan | COMPLETED |
| Protein Synthesis in the Brain of Patients With Fragile X Syndrome |
nan | COMPLETED |
| Molecular Genetic Study of Schizophrenia: Parent-Offspring Trios |
nan | COMPLETED |
| Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease |
nan | RECRUITING |
| Open-Label Study of Omega 3 Oil Supplementation for Aging-Related Cognitive Decline |
nan | COMPLETED |
| Clinical, Cellular, and Molecular Investigation Into Oculocutaneous Albinism |
nan | COMPLETED |
| Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN) |
nan | RECRUITING |
| Biomarker Research in Inherited Movement Disorders |
nan | RECRUITING |
Related proteins — ESM-2 sequence neighbours (a COG5 binder may also engage these)