Sugi Predict
/ Targets
/ COG7
Top predicted compounds (top 20 by supporting neighbours, then confidence)
| Compound | Confidence | Supporting neighbours |
|---|
Clinical trials — most relevant to COG7 by text similarity (a relevance ranking, not an exhaustive list)
| Trial | Phase | Status |
|---|
| Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) |
PHASE1/PHASE2 | NOT_YET_RECRUITING |
| Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) |
PHASE1/PHASE2 | RECRUITING |
| Safety and Efficacy of Tag-7 Gene-modified Vaccine in Locally Advanced or Metastatic Malignant Melanoma or Kidney Cancer |
PHASE1/PHASE2 | COMPLETED |
| Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacement Therapy |
PHASE2 | COMPLETED |
| A Study of MG7 Redirected Autologous T Cells for Advanced MG7 Positive Liver Metastases(MG7-CART) |
PHASE1/PHASE2 | UNKNOWN |
| Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma |
PHASE1 | COMPLETED |
| Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy |
PHASE1 | COMPLETED |
| The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism |
EARLY_PHASE1 | UNKNOWN |
| Study of the Pathophysiological Mechanisms Involved in Bleeding Events |
nan | COMPLETED |
| Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM) |
nan | COMPLETED |
| Investigations Into ISCU Myopathy or Iron Sulfur Scaffold U Protein Myopathy |
nan | COMPLETED |
| Autophagy in Systemic Lupus Erythematosus |
nan | UNKNOWN |
| MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study) |
nan | COMPLETED |
| Clinical, Cellular, and Molecular Investigation Into Oculocutaneous Albinism |
nan | COMPLETED |
| Molecular Genetic Study of Schizophrenia: Parent-Offspring Trios |
nan | COMPLETED |
| Role of Polymorphisms in the IL-1 Gene Cluster |
nan | COMPLETED |
| Phenotypic and Genotypic Studies in Congenital and Early Onset Ataxias |
nan | COMPLETED |
| Pediatric Evaluation and Registry for Liver Cholestasis in Canada |
nan | RECRUITING |
| Genetic Variations That Increase the Risk for Calcium Kidney Stones: a Family-based Study |
nan | COMPLETED |
| Study of Constitutional Platelet Disease |
nan | UNKNOWN |
| Identification of New FTLD Genes |
nan | UNKNOWN |
| PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Changes in the Hepatobiliary System in Patients With Primary Biliary Cholangitis Before and After Treatment. |
nan | ACTIVE_NOT_RECRUITING |
| Immune Cell Response to Stimuli |
nan | RECRUITING |
| Exome Analysis in Hearing Impaired Patients |
nan | UNKNOWN |
| RCDP Natural History Study |
nan | UNKNOWN |
| Protein Synthesis in the Brain of Patients With Fragile X Syndrome |
nan | COMPLETED |
| Genetic Association Study Between Single Nucleotide Polymorphisms (SNPs) and Cognitive Performance in Young Bipolar Type I Patients: LICAVALGENE |
nan | UNKNOWN |
| Genetic Characterization of Parkinson's Disease |
nan | COMPLETED |
| Genetic Analysis of Gray Platelet Syndrome |
nan | COMPLETED |
| Genetic Analysis of Hereditary Disorders of Hearing and Balance |
nan | COMPLETED |
Related proteins — ESM-2 sequence neighbours (a COG7 binder may also engage these)