COG7

Conserved oligomeric Golgi complex subunit 7

0 patent compounds predicted against COG7, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Germline variants in COG7 on Sugi Variant → ClinVar classifications, population frequency, and predictor agreement (AlphaMissense, SaProt, REVEL) Full COG7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

Clinical trials — most relevant to COG7 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47)	PHASE1/PHASE2	NOT_YET_RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)	PHASE1/PHASE2	RECRUITING
Safety and Efficacy of Tag-7 Gene-modified Vaccine in Locally Advanced or Metastatic Malignant Melanoma or Kidney Cancer	PHASE1/PHASE2	COMPLETED
Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacement Therapy	PHASE2	COMPLETED
A Study of MG7 Redirected Autologous T Cells for Advanced MG7 Positive Liver Metastases(MG7-CART)	PHASE1/PHASE2	UNKNOWN
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy	PHASE1	COMPLETED
The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism	EARLY_PHASE1	UNKNOWN
Study of the Pathophysiological Mechanisms Involved in Bleeding Events	nan	COMPLETED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
Investigations Into ISCU Myopathy or Iron Sulfur Scaffold U Protein Myopathy	nan	COMPLETED
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
Clinical, Cellular, and Molecular Investigation Into Oculocutaneous Albinism	nan	COMPLETED
Molecular Genetic Study of Schizophrenia: Parent-Offspring Trios	nan	COMPLETED
Role of Polymorphisms in the IL-1 Gene Cluster	nan	COMPLETED
Phenotypic and Genotypic Studies in Congenital and Early Onset Ataxias	nan	COMPLETED
Pediatric Evaluation and Registry for Liver Cholestasis in Canada	nan	RECRUITING
Genetic Variations That Increase the Risk for Calcium Kidney Stones: a Family-based Study	nan	COMPLETED
Study of Constitutional Platelet Disease	nan	UNKNOWN
Identification of New FTLD Genes	nan	UNKNOWN
PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Changes in the Hepatobiliary System in Patients With Primary Biliary Cholangitis Before and After Treatment.	nan	ACTIVE_NOT_RECRUITING
Immune Cell Response to Stimuli	nan	RECRUITING
Exome Analysis in Hearing Impaired Patients	nan	UNKNOWN
RCDP Natural History Study	nan	UNKNOWN
Protein Synthesis in the Brain of Patients With Fragile X Syndrome	nan	COMPLETED
Genetic Association Study Between Single Nucleotide Polymorphisms (SNPs) and Cognitive Performance in Young Bipolar Type I Patients: LICAVALGENE	nan	UNKNOWN
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Genetic Analysis of Gray Platelet Syndrome	nan	COMPLETED
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a COG7 binder may also engage these)

Protein	Name	Similarity
Q3T1G7	—	1.000	Q3T1G7 →
Q3UM29	—	1.000	Q3UM29 →
A2VDR8	—	1.000	A2VDR8 →
Q6NMI3	—	0.995	Q6NMI3 →
COG5	Conserved oligomeric Golgi complex subunit 5	0.994	landscape →
EXOC3	Exocyst complex component 3	0.992	landscape →
Q19262	—	0.991	Q19262 →
COG2	Conserved oligomeric Golgi complex subunit 2	0.991	landscape →
Q0V8C2	—	0.991	Q0V8C2 →
Q9JJA2	—	0.991	Q9JJA2 →
Q8CI04	—	0.991	Q8CI04 →
Q9V8K2	—	0.990	Q9V8K2 →
Q921L5	—	0.990	Q921L5 →
F4JRR1	—	0.990	F4JRR1 →
Q8MSY4	—	0.989	Q8MSY4 →
Q6KAR6	—	0.989	Q6KAR6 →
Q95TN4	—	0.989	Q95TN4 →
O54922	—	0.989	O54922 →
F4JHH5	—	0.989	F4JHH5 →
O35250	—	0.989	O35250 →
Q8C0L8	—	0.989	Q8C0L8 →
Q9VS46	—	0.989	Q9VS46 →
F4HQ84	—	0.988	F4HQ84 →
Q9VJD3	—	0.988	Q9VJD3 →
Q9VBY8	—	0.988	Q9VBY8 →
Q29N70	—	0.987	Q29N70 →
Q62825	—	0.987	Q62825 →
E7FC72	—	0.987	E7FC72 →
Q9LXX6	—	0.987	Q9LXX6 →
Q8WUM0	—	0.986	Q8WUM0 →