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GABRG3

Gamma-aminobutyric acid receptor subunit gamm · Q99928 · GABRG3 on Sugi Atlas →

109,291 patent compounds predicted against GABRG3, 56,960 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL15406 SCHEMBL15406 0.61 20/20
Fipronil Fipronil (SCHEMBL15088) 0.59 20/20
SCHEMBL41972 SCHEMBL41972 0.59 20/20
Fipronil Fipronil (SCHEMBL44222) 0.59 20/20
Ethiprole Ethiprole (SCHEMBL27048) 0.56 20/20
SCHEMBL25897 SCHEMBL25897 0.51 20/20
SCHEMBL33214 SCHEMBL33214 0.52 19/20
SCHEMBL26584 SCHEMBL26584 0.51 19/20
SCHEMBL9107 SCHEMBL9107 0.56 12/20
SCHEMBL8532 SCHEMBL8532 1.00 11/20
SCHEMBL9035 SCHEMBL9035 0.56 10/20
SCHEMBL8632 SCHEMBL8632 0.54 10/20
SCHEMBL8670 SCHEMBL8670 0.57 9/20
SCHEMBL8856 SCHEMBL8856 0.53 9/20
SCHEMBL9273 SCHEMBL9273 0.53 9/20
SCHEMBL8931 SCHEMBL8931 0.51 9/20
SCHEMBL8932 SCHEMBL8932 0.51 9/20
SCHEMBL9163 SCHEMBL9163 0.58 8/20
SCHEMBL8941 SCHEMBL8941 0.54 8/20
SCHEMBL8047 SCHEMBL8047 0.56 7/20

Clinical trials — most relevant to GABRG3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Computational Assessment of GABA Receptor Modulation in PTSD PHASE4RECRUITING
Safety of Ramelteon in Elderly Subjects PHASE4COMPLETED
The Effects of Levetiracetam on Alcohol Dependent Subjects PHASE4COMPLETED
Safety and Efficacy Study of Ramelteon in Subjects With Chronic Insomnia PHASE3COMPLETED
Safety and Efficacy of Ramelteon and Doxepin in Subjects With Chronic Insomnia PHASE2COMPLETED
Efficacy and Safety of Ramelteon Combined With Gabapentin in Treating Patients With Insomnia PHASE2COMPLETED
Diazepam Trial in GAD65 Associated Epilepsy PHASE1/PHASE2WITHDRAWN
Effects of Direct Transcranial Current Stimulation on Central Neural Pain Processing in Fibromyalgia PHASE1/PHASE2COMPLETED
Efficacy and Safety Study of Gabapentin as add-on to Morphine in Paediatric Patients Affected by Chronic Pain PHASE2WITHDRAWN
PET Imaging of Brain Peripheral Benzodiazepine Receptors PHASE1COMPLETED
The Use of Glutamic Acid Decarboxylase (GAD) and Gamma-Amino Butyric Acid (GABA) in the Treatment of Type I Diabetes PHASE1COMPLETED
PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28 PHASE1COMPLETED
MEG Study of Acute STX209 Effects in ASD EARLY_PHASE1COMPLETED
Imaging the Effects of Zolpidem and Alprazolam in Healthy Volunteers at 3T EARLY_PHASE1UNKNOWN
GABA Biomarkers in Dravet Syndrome nanRECRUITING
Cenobamate Efficacy in Individuals With Autoimmune Epilepsy nanENROLLING_BY_INVITATION
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy nanUNKNOWN
Integrins and Protocadherins in Glutamatergic Circuits: Identification of Common Signaling Pathways and Molecular Targets in Anxiety and Major Depressive Disorders (GAPsy) nanUNKNOWN
The Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Working Memory nanCOMPLETED
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery. nanCOMPLETED
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services nanUNKNOWN
GABRA2 and the Pharmacokinetics of Risk for Alcoholism (GPRA) nanCOMPLETED
Pilot Study Evaluating Neuro-Imaging Correlates of Epigenetic Finding in Prediction of Chronic Postsurgical Pain nanUNKNOWN
Assessment of Peripheral GABA Receptors for Local Pain Relief nanUNKNOWN
Functional Study of Inhibitory Neurotransmission in the Human Epileptic Brain. nanRECRUITING
Remifentanil and Remimazolam to Limit Patient Movement nanRECRUITING
GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression nanCOMPLETED
Mechanisms of Human Plasticity in the Human System nanCOMPLETED
Brain Changes in Patients With Focal Hand Dystonia nanCOMPLETED
Effect of Vitamin D Administration Along With SSRIs in Patients With Major Depressive Disorder nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a GABRG3 binder may also engage these)

ProteinNameSimilarity
P27681 — 0.998 P27681 →
P28473 — 0.997 P28473 →
P63138 — 0.969 P63138 →
P0C2W5 — 0.967 P0C2W5 →
P50571 — 0.966 P50571 →
P15431 — 0.965 P15431 →
P08220 — 0.962 P08220 →
GABRB3 Gamma-aminobutyric acid receptor subunit beta-3 0.960 landscape →
P19019 — 0.959 P19019 →
P63080 — 0.959 P63080 →
P63079 — 0.957 P63079 →
GABRB1 Gamma-aminobutyric acid receptor subunit beta-1 0.956 landscape →
P21548 — 0.951 P21548 →
P18508 — 0.950 P18508 →
P10063 — 0.950 P10063 →
P23576 — 0.948 P23576 →
GABRA2 Gamma-aminobutyric acid receptor subunit alpha-2 0.947 landscape →
Q5REA1 — 0.946 Q5REA1 →
GABRB2 Gamma-aminobutyric acid receptor subunit beta-2 0.945 landscape →
D1LYT2 — 0.945 D1LYT2 →
Q5RCC5 — 0.945 Q5RCC5 →
P26048 — 0.944 P26048 →
P63137 — 0.943 P63137 →
P22723 — 0.938 P22723 →
GABRG2 Gamma-aminobutyric acid receptor subunit gamm 0.936 landscape →
P22300 — 0.932 P22300 →
Q9R0Y8 — 0.925 Q9R0Y8 →
Q9WV18 — 0.924 Q9WV18 →
GABBR1 Gamma-aminobutyric acid type B receptor subunit 1 0.924 landscape →
P23574 — 0.923 P23574 →