CTRB2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL13401721	0.49	2/20
SCHEMBL13401747	0.44	2/20
SCHEMBL13401736	0.44	2/20
SCHEMBL15456413	1.00	1/20
SCHEMBL15456517	1.00	1/20
SCHEMBL15597198	1.00	1/20
SCHEMBL15597251	1.00	1/20
SCHEMBL16782297	1.00	1/20
Milvexian (SCHEMBL16971760)	0.91	1/20
Milvexian (SCHEMBL16972161)	0.91	1/20
SCHEMBL15594051	0.90	1/20
SCHEMBL15594137	0.89	1/20
SCHEMBL16910511	0.89	1/20
SCHEMBL15456817	0.88	1/20
SCHEMBL15594071	0.88	1/20
SCHEMBL15594200	0.88	1/20
SCHEMBL15594046	0.87	1/20
SCHEMBL15594274	0.87	1/20
SCHEMBL15594140	0.86	1/20
SCHEMBL15594199	0.86	1/20

Clinical trials — most relevant to CTRB2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography	PHASE4	UNKNOWN
Effect of Renin-angiotensin-system Blockade on Urinary Free Light Chains in Patients With Type 2 Diabetes Mellitus	PHASE4	COMPLETED
A Study to Evaluate the Clinical Efficacy and Safety of Subcutaneously Administered C1-esterase Inhibitor in the Prevention of Hereditary Angioedema	PHASE3	COMPLETED
Effect of Hyperglycemia in PAI-1 Activity and the Relationship With Outcome in Severe Sepsis and Septic Shock	PHASE2/PHASE3	COMPLETED
Comparative Clinical Study to Evaluate the Possible Efficacy and Safety of Oral N-Acetyl Cysteine Versus Rectal Diclofenac in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis	PHASE1/PHASE2	COMPLETED
Intravenous Alpha-1 Antitrypsin for Hospitalized Patients With COPD Exacerbations (AECOPD Study)	PHASE2	NOT_YET_RECRUITING
Genetic and Epidemiologic Studies of Premature Coronary Artery Disease - SCOR in Arteriosclerosis	nan	COMPLETED
Genetic Mechanisms of Chronic Obstructive Pulmonary Disease (COPD)	nan	COMPLETED
Markers in Acute Pancreatitis-1	nan	COMPLETED
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)	nan	RECRUITING
Presepsin as a Predictor for Postoperative Complications Following Pancreatic Resection	nan	COMPLETED
Pancreatic Exocrine Insufficiency and Pancreatic Enzyme Supplementation in Critically Ill Adult Patients	nan	COMPLETED
Post Acute Pancreatitis Pancreatic Exocrine Insufficiency	nan	COMPLETED
Defining the Molecular and Physiological Mechanisms of Pancreatic Islet Cell Dysfunction Which Lead to Type 2 Diabetes	nan	COMPLETED
Acute Pancreatitis Targets (APT) Study	nan	COMPLETED
Epidemiology of APO- and Lipoproteins in Elderly Women	nan	COMPLETED
Biomarker for Hereditary AngioEdema Disease	nan	COMPLETED
Evaluating the Relationship Between Blood Clotting Disorders, Inflammation, and Obesity in Individuals With Venous Disorders and Post-Thrombotic Syndrome	nan	COMPLETED
Belgian Antithrombin Deficiency Registry	nan	NOT_YET_RECRUITING
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH)	nan	COMPLETED
Effects of Vitamin D on Health Promotion During Pregnancy and Its Impact on Prematurity-Related Outcome	nan	UNKNOWN
Response Options to Blood Volume Monitoring in Fluid Overloaded Hemodialysis Patients	nan	COMPLETED
Exocrine Pancreatic Function Testing in Cystic Fibrosis	nan	UNKNOWN
Pharmacogenomic Response to Thyrotropin-Releasing Hormone Stimulation in Healthy Volunteers: The Influence of a Common Type 2 Deiodinase Genetic Polymorphism on Serum T3	nan	COMPLETED
Evaluation of Plasma Renin Concentrations in Cardiac Surgery	nan	RECRUITING
Genetic Modifiers of Cystic Fibrosis: Sibling Study	nan	COMPLETED
Counter-Regulatory Hormonal and Stress Systems in Patients With COVID-19	nan	COMPLETED
Management of Coagulopathy in Cirrhotic Patients Undergoing Invasive Procedures	nan	UNKNOWN
The North American Pancreatitis Study	nan	COMPLETED
CTRP3 and Progranulin in Patients With Coronary Artery Disease	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CTRB2 binder may also engage these)

Protein	Name	Similarity
CTRB1	Chymotrypsinogen B	1.000	landscape →
P04813	—	1.000	P04813 →
P00767	—	0.996	P00767 →
P07338	—	0.995	P07338 →
Q9CR35	—	0.995	Q9CR35 →
P80646	—	0.992	P80646 →
P00766	—	0.987	P00766 →
P47796	—	0.984	P47796 →
P15949	—	0.983	P15949 →
P00756	—	0.982	P00756 →
P00755	—	0.981	P00755 →
P80009	—	0.980	P80009 →
P29787	—	0.979	P29787 →
P00759	—	0.979	P00759 →
Q9JM71	—	0.979	Q9JM71 →
P04071	—	0.978	P04071 →
P07647	—	0.978	P07647 →
Q91508	—	0.978	Q91508 →
P15947	—	0.977	P15947 →
P80010	—	0.977	P80010 →
Q072L7	—	0.976	Q072L7 →
Q924N9	—	0.976	Q924N9 →
P15945	—	0.976	P15945 →
CTRL	Chymotrypsin-like protease CTRL-1	0.976	landscape →
P81286	—	0.976	P81286 →
Q61754	—	0.975	Q61754 →
P36368	—	0.975	P36368 →
P51588	—	0.974	P51588 →
P36369	—	0.974	P36369 →
Q91507	—	0.974	Q91507 →