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Sugi Predict / Targets / DNM1L

DNM1L

Dynamin-1-like protein · O00429 · DNM1L on Sugi Atlas →

1,966 patent compounds predicted against DNM1L, 693 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL20548125 SCHEMBL20548125 1.00 20/20
SCHEMBL20548128 SCHEMBL20548128 1.00 20/20
SCHEMBL20548145 SCHEMBL20548145 1.00 20/20
SCHEMBL20548154 SCHEMBL20548154 1.00 20/20
SCHEMBL20548155 SCHEMBL20548155 1.00 20/20
SCHEMBL21875237 SCHEMBL21875237 1.00 20/20
SCHEMBL21875244 SCHEMBL21875244 1.00 20/20
SCHEMBL21875246 SCHEMBL21875246 1.00 20/20
SCHEMBL21875249 SCHEMBL21875249 1.00 20/20
SCHEMBL21875251 SCHEMBL21875251 1.00 20/20
SCHEMBL21875252 SCHEMBL21875252 1.00 20/20
SCHEMBL21875254 SCHEMBL21875254 1.00 20/20
SCHEMBL21875255 SCHEMBL21875255 1.00 20/20
SCHEMBL21875257 SCHEMBL21875257 1.00 20/20
SCHEMBL21875259 SCHEMBL21875259 1.00 20/20
SCHEMBL21875262 SCHEMBL21875262 1.00 20/20
SCHEMBL21875263 SCHEMBL21875263 1.00 20/20
SCHEMBL21875267 SCHEMBL21875267 1.00 20/20
SCHEMBL21875270 SCHEMBL21875270 1.00 20/20
SCHEMBL21875271 SCHEMBL21875271 1.00 20/20

Clinical trials — most relevant to DNM1L by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Motor Function Efficacy of Pharmacological Treatments Targeting Energy Metabolism, in Parkinson's Patients PHASE4UNKNOWN
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) PHASE1/PHASE2NOT_YET_RECRUITING
Nilotinib in Huntington's Disease PHASE1UNKNOWN
A Clinical Study to Evaluate the Safety of MF1, a New Treatment for Parkinson's Disease-related Disorders (MF1 Study) PHASE1RECRUITING
S-Equol in Alzheimer's Disease (SEAD) Trial PHASE1COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D) EARLY_PHASE1COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise nanCOMPLETED
Skeletal Muscle Regeneration in Survivors of Critical Illness: How to Prevent Satellite Cell Failure? nanRECRUITING
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy nanCOMPLETED
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men nanRECRUITING
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease nanUNKNOWN
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP) nanNOT_YET_RECRUITING
Cell Membrane Potential Regulates Spatial-Specific Mechanoptosis Resistance and Metastasis in Colorectal Cancer Via Mechanotransduction and the PVR/CD96 Axis nanCOMPLETED
Muscle Insulin Resistance in Aging (Mirage) nanACTIVE_NOT_RECRUITING
Combining Gene Variants to Improve Risk Prediction for Metabolic (Dysfunction)- Associated Fatty Liver Disease and Its Progression to Cirrhosis in Indian Individuals With Type 2 Diabetes nanCOMPLETED
Ultrastructural Characteristics of Mitochondria in Cardiomyocytes in Heart Failure nanRECRUITING
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide nanRECRUITING
The Natural History of Mitochondrial Diseases nanRECRUITING
Optimistic and Pessimistic Dopamine Signals in the Human Brain: a Mapping and Modelling Study in Health and Parkinson's Disease nanRECRUITING
sCD163 in ALS Patients nanCOMPLETED
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction nanCOMPLETED
Identification of New Biomarkers of Insulin Resistance nanACTIVE_NOT_RECRUITING
Autophagy/Apoptosis Balance in Placental Vascular Pathologies nanRECRUITING
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study) nanCOMPLETED
Rab 32 Gene Polymorphisms as a Prognostic Factor in Leprosy Patients nanRECRUITING
Understanding Alpha-Synuclein Spread in Parkinson's Disease Through Blood Biomarkers and Neuroimaging nanNOT_YET_RECRUITING
Autophagy Bladder Cancer nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a DNM1L binder may also engage these)

ProteinNameSimilarity
O35303 — 1.000 O35303 →
Q2KIA5 — 1.000 Q2KIA5 →
Q7SXN5 — 0.999 Q7SXN5 →
Q8WQC9 — 0.999 Q8WQC9 →
Q8K1M6 — 0.999 Q8K1M6 →
Q9URZ5 — 0.991 Q9URZ5 →
DNM2 Dynamin-2 0.991 landscape →
Q09748 — 0.991 Q09748 →
P39052 — 0.990 P39052 →
P39054 — 0.990 P39054 →
P39053 — 0.989 P39053 →
P20591 — 0.988 P20591 →
Q08877 — 0.988 Q08877 →
P21576 — 0.988 P21576 →
Q5R5G3 — 0.988 Q5R5G3 →
Q8BZ98 — 0.988 Q8BZ98 →
Q9UQ16 — 0.987 Q9UQ16 →
P79135 — 0.987 P79135 →
P54861 — 0.987 P54861 →
Q811U4 — 0.987 Q811U4 →
P33237 — 0.987 P33237 →
Q8R4Z9 — 0.986 Q8R4Z9 →
P21575 — 0.986 P21575 →
Q9N0Y2 — 0.986 Q9N0Y2 →
Q8S944 — 0.986 Q8S944 →
Q28379 — 0.986 Q28379 →
Q39821 — 0.986 Q39821 →
Q7T2P0 — 0.985 Q7T2P0 →
Q08DF4 — 0.985 Q08DF4 →
Q9FNX5 — 0.985 Q9FNX5 →