EIF3D — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL4697866	0.89	2/20
SCHEMBL24532075	0.89	2/20
SCHEMBL22119546	0.82	2/20
SCHEMBL24532060	0.77	2/20
SCHEMBL4698636	0.76	2/20
SCHEMBL24532064	0.74	2/20
SCHEMBL4699183	0.74	2/20
SCHEMBL24532023	0.74	2/20
SCHEMBL24532034	0.73	2/20
SCHEMBL24532065	0.72	2/20
SCHEMBL4696222	0.72	2/20
SCHEMBL24532025	0.69	2/20
SCHEMBL21943424	0.68	2/20
SCHEMBL20439526	0.68	2/20
SCHEMBL22024572	0.67	2/20
SCHEMBL4920392	0.66	2/20
SCHEMBL21942991	0.66	2/20
SCHEMBL22024838	0.65	2/20
SCHEMBL24532076	0.65	2/20
SCHEMBL29728046	0.64	2/20

Clinical trials — most relevant to EIF3D by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Liraglutide on ER Stress in Obese Patients With Type 2 Diabetes	PHASE4	UNKNOWN
Antiviral Activity and Safety of 3 Different Doses of Mifepristone in Hepatitis C Infected Patients	PHASE2	COMPLETED
ISIS 183750 With Irinotecan for Advanced Solid Tumors or Colorectal Cancer	PHASE1/PHASE2	COMPLETED
Everolimus for Children With Recurrent or Progressive Ependymoma	PHASE2	COMPLETED
Decitabine and Venetoclax Treatment as Maintenance Therapy in Patients Post Allograft Stem Cell Transplant	PHASE1/PHASE2	RECRUITING
Study of Decitabine in Combination With Sequential Rapamycin or Ribavirin in High Risk AML Patients	PHASE1/PHASE2	COMPLETED
Cediranib Maleate in Treating Patients With Recurrent or Persistent Endometrial Cancer	PHASE2	COMPLETED
A Study of Hydroxychloroquine in Combination With Gemcitabine/Abraxane in Pancreatic Cancer	PHASE1/PHASE2	COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Treatment Duration Increment and Pharmacodynamic Study of CX-4945 in Patients With Basal Cell Carcinoma (BCC)	PHASE1	COMPLETED
Bristol-Myers Squibb Dasatinib Src Inhibition in Endometrial Cancer	EARLY_PHASE1	COMPLETED
Quantification of GADD34 Expression in RA	nan	COMPLETED
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress	nan	WITHDRAWN
MEHMO Natural History and Biomarkers	nan	RECRUITING
Endolymphatic Sac Tumors in a Population of Patients With Von Hippel-Lindau Disease:The Natural History and Pathobiology, and a Prospective Non-Randomized Clinical Trial of Hearing Preservation Surgery in Patients With Early Stage Endolymphatic Sac Tumors	nan	COMPLETED
Effect of Branched Chain Amino Acids on Muscle	nan	COMPLETED
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy	nan	UNKNOWN
SMYD3-Driven Metabolic Rewiring in Colorectal Liver Metastases	nan	NOT_YET_RECRUITING
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING
Prognostic Value of Protein IMP3 Expression in Cervical Cancer	nan	COMPLETED
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML)	nan	COMPLETED
A Study of Serum Protein Profiling in Patients With Non-Small Cell Lung Cancer Treated With Gefitinib or Erlotinib	nan	COMPLETED
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Circulating Biomarker Signatures for the Detection of Gastric Preneoplasia and Cancer	nan	RECRUITING
miRNA as a Growth Plate Marker After GH	nan	UNKNOWN
Prediction of Chronic Allograft Nephropathy	nan	COMPLETED
Protein Intake and Step Reduction in Older Adults	nan	COMPLETED
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic	nan	COMPLETED
Detection of EGFR Mutation in Malignant Pleural Effusion of Lung Cancer Patients and Cancer Cell Lines Establishment	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a EIF3D binder may also engage these)

Protein	Name	Similarity
Q5R925	—	1.000	Q5R925 →
Q7ZTM9	—	1.000	Q7ZTM9 →
Q6P8G0	—	1.000	Q6P8G0 →
O70194	—	1.000	O70194 →
Q4R8R4	—	1.000	Q4R8R4 →
Q3T122	—	1.000	Q3T122 →
Q6AYK8	—	1.000	Q6AYK8 →
K7IM66	—	1.000	K7IM66 →
Q7QBW3	—	1.000	Q7QBW3 →
Q6TH15	—	1.000	Q6TH15 →
B4JTN0	—	1.000	B4JTN0 →
A7SMR1	—	0.999	A7SMR1 →
Q9VCK0	—	0.999	Q9VCK0 →
B3P1F9	—	0.998	B3P1F9 →
B4NLG2	—	0.998	B4NLG2 →
Q16UF8	—	0.998	Q16UF8 →
B4LYI3	—	0.998	B4LYI3 →
Q0ZB77	—	0.998	Q0ZB77 →
P30642	—	0.998	P30642 →
B3LY71	—	0.998	B3LY71 →
B4HFV9	—	0.998	B4HFV9 →
B4K892	—	0.998	B4K892 →
B4N8Z4	—	0.997	B4N8Z4 →
B0X6P7	—	0.997	B0X6P7 →
B3P8G6	—	0.997	B3P8G6 →
B4M5A7	—	0.997	B4M5A7 →
A8X371	—	0.997	A8X371 →
B4JUM0	—	0.997	B4JUM0 →
B4PNN4	—	0.996	B4PNN4 →
Q0UVG7	—	0.996	Q0UVG7 →