FXYD2

Sodium/potassium-transporting ATPase subunit · P54710 · FXYD2 on Sugi Atlas →

17,542 patent compounds predicted against FXYD2, 10,087 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL475105	0.51	15/20
SCHEMBL475107	0.51	15/20
SCHEMBL1484406	0.65	14/20
SCHEMBL1483332	0.74	13/20
SCHEMBL1483335	0.74	13/20
Uzarin (SCHEMBL702463)	0.92	12/20
Digitoxigenin Gentiobioside (SCHEMBL702464)	0.92	12/20
Digitoxigenin Gentiobioside (SCHEMBL1652279)	0.92	12/20
Ramnodigin (SCHEMBL1812161)	0.84	12/20
Actodigin (SCHEMBL122586)	0.74	12/20
SCHEMBL1483283	0.66	12/20
SCHEMBL714901	0.63	12/20
SCHEMBL2258970	0.63	12/20
SCHEMBL2256038	0.61	12/20
SCHEMBL2256162	0.61	12/20
SCHEMBL2256169	0.61	12/20
SCHEMBL255971	0.60	12/20
SCHEMBL716452	0.60	12/20
SCHEMBL174232	0.59	12/20
SCHEMBL256803	0.59	12/20

Clinical trials — most relevant to FXYD2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Pharmacogenomic Evaluation of Antihypertensive Responses	PHASE4	COMPLETED
Safety and Efficacy of Etravirine in Friedreich Ataxia Patients	PHASE2	COMPLETED
Hereditary Tubulointerstitial Nephritis	nan	COMPLETED
Sodium Transport: Genetics and Hypertension	nan	COMPLETED
Anthropogenetic Variability in the Group of Individuals With Febrile Seizures	nan	COMPLETED
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED
Pathogenic Insights and Search for Biomarkers in RFC1-ataxia/CANVAS	nan	RECRUITING
Validation of the RADIAL Algorithm for Diagnosis of Autosomal Recessive Cerebellar Ataxia	nan	RECRUITING
Ethnic Differences in Iron Absorption (FeGenes)	nan	ACTIVE_NOT_RECRUITING
Family Blood Pressure Program - HyperGEN	nan	COMPLETED
Von Hippel-Lindau (VHL): Clinical Manifestations, Diagnosis, Management and Molecular Bases of Inherited Renal and Other Urologic Malignant Disorders	nan	RECRUITING
Oxalate and Citrate in Humans - Response to Citrate	nan	RECRUITING
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts	nan	COMPLETED
Family Blood Pressure Program - GENOA	nan	COMPLETED
Signs and Symptoms of Genetic Abnormalities Linked to Inherited Heart Disease	nan	COMPLETED
Coproporphyrine Isomers and Methotrexate Elimination	nan	COMPLETED
Hemochromatosis and Iron Overload Screening Study (HEIRS)	nan	COMPLETED
Determining the Association of Chromosomal Variants With Non-PV Triggers and Ablation-outcome in AF (DECAF)	nan	COMPLETED
Family Blood Pressure Program - SAPPHIRe Network	nan	COMPLETED
Signs and Symptoms Associated With Molecular Defects in Genetically Inherited Heart Disease	nan	COMPLETED
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan	nan	ENROLLING_BY_INVITATION
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients.	nan	UNKNOWN
Family Blood Pressure Program - GenNet Network	nan	COMPLETED
A Study to Assess Variation in Potential Biomarkers in Friedreich Ataxia	nan	COMPLETED
Natural History and Outcomes in X-Linked Hypohidrotic Ectodermal Dysplasia	nan	COMPLETED
Structural Validity and Inter-rater Reliabitiliy of the Ataxia Trunk, Lower And Upper Extremity Scale (ATLAS)	nan	NOT_YET_RECRUITING
Prevalence and Risk Factors of Nephrocalcinosis in Children at Sohag University Hospital	nan	UNKNOWN
Pediatric Cardiomyopathy Mutation Analysis	nan	RECRUITING
Genetic Testing in Detection of Late-Onset Hearing Loss	nan	COMPLETED
X-chromosome Inactivation, Epigenetics and the Transcriptome	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a FXYD2 binder may also engage these)

Protein	Name	Similarity
Q04679	—	0.997	Q04679 →
Q04646	—	0.984	Q04646 →
Q04645	—	0.981	Q04645 →
Q04680	—	0.980	Q04680 →
Q91XV6	—	0.970	Q91XV6 →
Q9H0Q3	—	0.970	Q9H0Q3 →
Q8BXZ0	—	0.969	Q8BXZ0 →
Q61835	—	0.968	Q61835 →
Q5RB29	—	0.968	Q5RB29 →
Q14802	—	0.968	Q14802 →
Q4R566	—	0.967	Q4R566 →
P59645	—	0.966	P59645 →
Q3MHZ5	—	0.965	Q3MHZ5 →
O97797	—	0.965	O97797 →
Q9D164	—	0.965	Q9D164 →
Q3SZX0	—	0.963	Q3SZX0 →
W5P3P0	—	0.962	W5P3P0 →
Q4LDR2	—	0.961	Q4LDR2 →
Q08CB3	—	0.960	Q08CB3 →
O73698	—	0.957	O73698 →
Q86T20	—	0.957	Q86T20 →
Q9D2W0	—	0.957	Q9D2W0 →
Q5VXT5	—	0.956	Q5VXT5 →
Q9CQM1	—	0.956	Q9CQM1 →
Q502I1	—	0.956	Q502I1 →
P56513	—	0.956	P56513 →
Q9Z239	—	0.955	Q9Z239 →
Q8NEW7	—	0.955	Q8NEW7 →
Q8R043	—	0.954	Q8R043 →
D3ZWZ9	—	0.954	D3ZWZ9 →