Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 11/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | G6PC1 | P35575 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 9/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4885008 | 1.00 | MEN1 (0.50) | MEN1KMT2AALDH1A1SMN1; SMN2MCL1 | |
| SCHEMBL14005045 | 0.94 | G6PC1 (0.49) | MEN1KMT2AALDH1A1SMN1; SMN2MCL1 | |
| SCHEMBL13879231 | 0.83 | MEN1 (0.53) | MEN1KMT2AALDH1A1SMN1; SMN2MCL1 | |
| SCHEMBL4749060 | 0.82 | MEN1 (0.45) | MEN1KMT2AALDH1A1SMN1; SMN2MCL1 | |
| SCHEMBL4749054 | 0.82 | MEN1 (0.45) | MEN1KMT2AALDH1A1SMN1; SMN2MCL1 | |
| SCHEMBL9497879 | 0.81 | MEN1 (0.44) | MEN1KMT2AALDH1A1SMN1; SMN2MCL1 | |
| SCHEMBL8494526 | 0.80 | MAPT (0.57) | MEN1KMT2AALDH1A1SMN1; SMN2MCL1 | |
| SCHEMBL8494529 | 0.80 | MAPT (0.57) | MEN1KMT2AALDH1A1SMN1; SMN2MCL1 | |
| SCHEMBL10531365 | 0.77 | KMT2A (0.62) | MEN1KMT2AALDH1A1SMN1; SMN2MCL1 | |
| SCHEMBL11988034 | 0.77 | MEN1 (0.55) | MEN1KMT2AALDH1A1SMN1; SMN2MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293711-A1 | Chemokine receptor modulators | METASTATIX, INC. | 2008-11-27 | — | — | US | disclosed |
| US-20080293711-A1 | Chemokine receptor modulators | METASTATIX, INC. | 2008-11-27 | — | — | US | disclosed |
| US-20080293711-A1 | Chemokine receptor modulators | METASTATIX, INC. | 2008-11-27 | — | — | US | disclosed |
| WO-2008112156-A1 | CHEMOKINE RECEPTOR MODULATORS | ALTIRIS THERAPEUTICS (US) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008112156-A1 | CHEMOKINE RECEPTOR MODULATORS | ALTIRIS THERAPEUTICS (US) | 2008-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293711-A1 | Chemokine receptor modulators | CCR5, CCL2, CXCR4 | MEN1 3669/4885KMT2A 4463/4885ALDH1A1 1359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.