GEMIN4

Gem-associated protein 4 · P57678 · GEMIN4 on Sugi Atlas →

154 patent compounds predicted against GEMIN4, 134 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Dehydrocurvularin (SCHEMBL23515575)	1.00	1/20
Dehydrocurvularin (SCHEMBL23515579)	1.00	1/20
SCHEMBL29711356	0.68	1/20
Xestodecalactone A (SCHEMBL2874661)	0.67	1/20
Curvularin (SCHEMBL2140562)	0.64	1/20
Curvularin (SCHEMBL15256930)	0.64	1/20
Curvularin (SCHEMBL29928932)	0.64	1/20
Curvularin (SCHEMBL30556710)	0.64	1/20
SCHEMBL18543028	0.61	1/20
SCHEMBL14213082	0.61	1/20
SCHEMBL18780580	0.58	1/20
SCHEMBL14293646	0.56	1/20
SCHEMBL24565317	0.55	1/20
SCHEMBL109175	0.55	1/20
SCHEMBL342587	0.55	1/20
SCHEMBL342992	0.55	1/20
SCHEMBL343610	0.55	1/20
SCHEMBL588697	0.55	1/20
SCHEMBL588698	0.55	1/20
SCHEMBL588699	0.55	1/20

Clinical trials — most relevant to GEMIN4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Trial of Sodium Valproate in Amyotrophic Lateral Sclerosis	PHASE3	COMPLETED
GM604 Phase 2A Randomized Double-blind Placebo Controlled Pilot Trial in Amyotrophic Lateral Disease (ALS)	PHASE2	COMPLETED
Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy	PHASE1	COMPLETED
Natural History Study of GEMIN-5 Related Neurodevelopmental Disorder	nan	RECRUITING
Mechanisms of Cell Death in Spinal Muscular Atrophy	nan	COMPLETED
Spinal Muscular Atrophy (SMA) Biomarkers Study in the Immediate Postnatal Period of Development	nan	COMPLETED
B3 for NMD: Bench to Bedside and Back	nan	ENROLLING_BY_INVITATION
Amyotrophic Lateral Sclerosis (ALS) Families Project	nan	RECRUITING
Muscle Tissue Bank for Muscular Dystrophy	nan	COMPLETED
Molecular and Genetic Studies of Congenital Myopathies	nan	RECRUITING
A Multicenter Phenotype-Genotype Analysis of LGMD Patients in China	nan	ENROLLING_BY_INVITATION
Germline Mutations in Pancreatic Adenocarcinoma	nan	COMPLETED
CoMPaSS-NMD - Computational Models for New Patients Stratification Strategies of HNMD	nan	ENROLLING_BY_INVITATION
Efficacy of Cognitive Rehabilitation Using Virtual Reality and Computer-based Cognitive Stimulation on Cognitive Impairment Associated to Movement Disorders	nan	COMPLETED
Biomarkers in SCOTland CardiomyopatHy Registry (Bio-SCOTCH)	nan	RECRUITING
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others	nan	RECRUITING
Pediatric Evaluation and Registry for Liver Cholestasis in Canada	nan	RECRUITING
Pancreatic Intraepithelial Neoplasia (PanIN) and the Association With Recurrence of Pancreatic Adenocarcinoma	nan	COMPLETED
Optical and Biochemical Biomarkers in Early Pancreatic Cancer	nan	COMPLETED
Mapping Novel Disease Genes for Dilated Cardiomyopathy	nan	COMPLETED
Natural History Study for Patients With Nemaline Myopathy in Belgium	nan	NOT_YET_RECRUITING
Genetic Susceptibility in MAlignant Pleural Mesothelioma: Clinical Implication of GermliNE variaTionS	nan	RECRUITING
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH)	nan	COMPLETED
Changes of Motor Function Tests in Congenital Myopathy Subjects Treated With Oral Salbutamol as Compared to no Treatment	nan	COMPLETED
Collection of Blood Samples for DNA in Motor Neuron Disease	nan	COMPLETED
ClinSeq: A Large-Scale Medical Sequencing Clinical Research Pilot Study	nan	ACTIVE_NOT_RECRUITING
Pleiotropy and Mechanism of Peripheral Nerve Related Genes in the Progression of Amyotrophic Lateral Sclerosis	nan	UNKNOWN
MYO-SHARE: MYO-MRI in Neuromuscular Diseases	nan	ENROLLING_BY_INVITATION
Genetics of Familial and Sporadic ALS	nan	COMPLETED
MNGIE Natural History Study	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a GEMIN4 binder may also engage these)

Protein	Name	Similarity
O35870	—	1.000	O35870 →
P50652	—	1.000	P50652 →
O19104	—	0.999	O19104 →
Q5MNV8	—	0.999	Q5MNV8 →
Q9BVR0	—	0.998	Q9BVR0 →
Q80UK8	—	0.998	Q80UK8 →
E9Q555	—	0.998	E9Q555 →
Q9HCE0	—	0.997	Q9HCE0 →
A5WUT8	—	0.997	A5WUT8 →
URB2	Unhealthy ribosome biogenesis protein 2 homolog	0.997	landscape →
E1C7U0	—	0.997	E1C7U0 →
Q75QN2	—	0.997	Q75QN2 →
Q8CE72	—	0.997	Q8CE72 →
Q80TA9	—	0.997	Q80TA9 →
ATR	Serine/threonine-protein kinase ATR	0.997	landscape →
C5J7W8	—	0.997	C5J7W8 →
B0V0U5	—	0.996	B0V0U5 →
Q9TTK4	—	0.996	Q9TTK4 →
Q4V847	—	0.996	Q4V847 →
Q3UVY5	—	0.996	Q3UVY5 →
Q96N11	—	0.996	Q96N11 →
RNF213	E3 ubiquitin-protein ligase RNF213	0.995	landscape →
Q2TL32	—	0.995	Q2TL32 →
E1BLZ4	—	0.995	E1BLZ4 →
Q6CAD2	—	0.995	Q6CAD2 →
UBR4	E3 ubiquitin-protein ligase UBR4	0.995	landscape →
Q68DK2	—	0.995	Q68DK2 →
A2A6H3	—	0.995	A2A6H3 →
Q9H0H0	—	0.994	Q9H0H0 →
Q5EB59	—	0.994	Q5EB59 →