ABHD12

Lysophosphatidylserine lipase ABHD12 · Q8N2K0 · ABHD12 on Sugi Atlas →

3,094 patent compounds predicted against ABHD12, 2,449 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Dronabinol (SCHEMBL4609)	1.00	3/20
Dronabinol (SCHEMBL1114909)	1.00	3/20
Dronabinol (SCHEMBL1227386)	1.00	3/20
Dronabinol (SCHEMBL3686519)	1.00	3/20
Dronabinol (SCHEMBL5078018)	1.00	3/20
Dronabinol (SCHEMBL4732979)	0.90	3/20
Dronabinol (SCHEMBL1517514)	0.86	3/20
Tetrahydrocannabivarin (SCHEMBL245827)	0.86	3/20
Tetrahydrocannabivarin (SCHEMBL6856739)	0.86	3/20
SCHEMBL279762	0.79	3/20
SCHEMBL10068289	0.78	3/20
SCHEMBL997050	0.78	3/20
SCHEMBL2615500	0.77	3/20
SCHEMBL3954439	0.75	3/20
Dronabinol (SCHEMBL9746995)	0.75	3/20
Dronabinol (SCHEMBL447183)	0.72	3/20
Dronabinol (SCHEMBL6120559)	0.72	3/20
SCHEMBL2475041	0.72	3/20
Dronabinol (SCHEMBL1697394)	0.71	3/20
Dronabinol (SCHEMBL8333793)	0.70	3/20

Clinical trials — most relevant to ABHD12 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Acid Lipase Replacement Investigating Safety and Efficacy (ARISE) in Participants With Lysosomal Acid Lipase Deficiency	PHASE3	COMPLETED
Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Sebelipase Alfa in Children With Growth Failure Due to Lysosomal Acid Lipase Deficiency	PHASE2/PHASE3	COMPLETED
Cholic Acid for Hepatic Steatosis in Lipodystrophy	PHASE2	COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides	PHASE1	COMPLETED
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes	nan	RECRUITING
Abnormal Lipids - Causes and Effects	nan	RECRUITING
Identification of a New Gene Involved in Hereditary Lipodystrophy	nan	COMPLETED
Lipodystrophy Connect Patient Registry	nan	COMPLETED
Study to Re-assess and Re-confirm Data Previously Recorded About the Incidence and Severity of Acute Abdominal Pancreatitis Episodes in Lipoprotein Lipase Deficient (LPLD) Subjects Previously Enrolled on AMT Clinical Studies	nan	UNKNOWN
The Classification and Cause of Leukodystrophies of Unknown Cause	nan	COMPLETED
Identification of Women With Severe Insulin Resistant Syndromes of Genetic Origin Among Patients With Classic Polycystic Ovary Syndrome (PCOS)	nan	NOT_YET_RECRUITING
the Role of plin5 in the Development of Nonalcoholic Fatty Liver Disease.	nan	UNKNOWN
The Association Between Post-ERCP Acute Pancreatitis and Various Genetic Mutations	nan	COMPLETED
Leptin for Abnormal Lipid Kinetics in HIV Lipodystrophy Syndrome	nan	COMPLETED
Lipa Gene Mutation in PED-LIPIGEN (Pediatric FH Subjects)	nan	UNKNOWN
Circadian Rhythms in Human Adipose	nan	RECRUITING
NIAID Clinical Center Genomics Opportunity Protocol	nan	COMPLETED
Genes Involved in Lipid Disorders	nan	COMPLETED
Genetic Origin of Lipid Disorders	nan	UNKNOWN
The Efficacy of Pedometer-motivated Physical Activity for the Management of Patients With MASLD.	nan	ENROLLING_BY_INVITATION
A Retrospective Natural History Study of Patients With Lysosomal Acid Lipase Deficiency/Wolman Phenotype	nan	COMPLETED
PCD New Gene Discovery	nan	COMPLETED
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH)	nan	COMPLETED
Biomarker for Wolman Disease (BioWolman)	nan	WITHDRAWN
In Vivo Metabolism of apoB-containing Lipoproteins in ANGPTL3 Deficient Subjects	nan	UNKNOWN
Lysosomal Acid Lipase (LAL) Deficiency Registry	nan	RECRUITING
Registry Gangliosidoses	nan	UNKNOWN
Polygenic Risk Score to Predict Weight Loss Intervention in Children With Obesity	nan	UNKNOWN
An Observational Study of Patients With Lysosomal Acid Lipase Deficiency/Cholesteryl Ester Storage Disease Phenotype	nan	COMPLETED
National Multicentre Study of the Natural History of Acid Sphingo-myelinase Deficiency in Adults and Children	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a ABHD12 binder may also engage these)

Protein	Name	Similarity
Q4R766	—	1.000	Q4R766 →
Q5ZIN0	—	0.998	Q5ZIN0 →
Q6AYT7	—	0.995	Q6AYT7 →
Q08DW9	—	0.995	Q08DW9 →
Q99LR1	—	0.990	Q99LR1 →
B4F753	—	0.958	B4F753 →
Q6DD70	—	0.956	Q6DD70 →
Q6GL10	—	0.952	Q6GL10 →
GLS	Glutaminase kidney isoform, mitochondrial	0.952	landscape →
Q99JW1	—	0.952	Q99JW1 →
Q3UHN9	—	0.951	Q3UHN9 →
Q01134	—	0.950	Q01134 →
CHKA	Choline kinase alpha	0.950	landscape →
Q02353	—	0.950	Q02353 →
P52848	—	0.950	P52848 →
D3Z7P3	—	0.948	D3Z7P3 →
Q9EPL4	—	0.948	Q9EPL4 →
Q5XIJ5	—	0.948	Q5XIJ5 →
Q9NVE7	—	0.948	Q9NVE7 →
Q9H1A3	—	0.947	Q9H1A3 →
Q0VCJ8	—	0.947	Q0VCJ8 →
Q96GS6	—	0.946	Q96GS6 →
Q5R5F8	—	0.946	Q5R5F8 →
O54804	—	0.946	O54804 →
Q91YD4	—	0.946	Q91YD4 →
P13264	—	0.945	P13264 →
Q4R4U1	—	0.945	Q4R4U1 →
Q8WWQ2	—	0.944	Q8WWQ2 →
Q2HJ19	—	0.944	Q2HJ19 →
Q9H3R1	—	0.943	Q9H3R1 →