Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.50 |
| ▸ | GPX4 | P36969 | 8/20 | 0.46 |
| ▸ | DHFR | P00374 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3126018 | 0.95 | DHFR (0.48) | KDM4EALDH1A1MAPTAPAF1GPX4 | |
| SCHEMBL3131179 | 0.93 | F2 (0.42) | KDM4EALDH1A1MAPTAPAF1GPX4 | |
| SCHEMBL3129490 | 0.86 | F7 (0.41) | KDM4EALDH1A1MAPTAPAF1GPX4 | |
| SCHEMBL3118081 | 0.84 | PDE4B (0.41) | KDM4EALDH1A1MAPTGPX4KMT2A | |
| SCHEMBL3121001 | 0.84 | GPX4 (0.44) | KDM4EALDH1A1MAPTGPX4KMT2A | |
| SCHEMBL3129552 | 0.82 | GPX4 (0.43) | KDM4EALDH1A1MAPTGPX4KMT2A | |
| SCHEMBL3117592 | 0.79 | MAPT (0.58) | KDM4EALDH1A1MAPTAPAF1GPX4 | |
| SCHEMBL3121042 | 0.79 | BRD4 (0.50) | KDM4EALDH1A1MAPTAPAF1GPX4 | |
| SCHEMBL2908810 | 0.78 | EGFR (0.45) | KDM4EALDH1A1MAPTGPX4GAA | |
| SCHEMBL16421384 | 0.76 | IMPDH2 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003084-A2 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |