Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | AKT2 | P31751 | 2/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.50 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17633566 | 0.84 | IKBKB (0.54) | KDM4EPOLBSMN1; SMN2MAPTNPC1 | |
| SCHEMBL23486367 | 0.80 | KDM4E (0.51) | KDM4E | |
| SCHEMBL6852749 | 0.79 | KDM4E (0.57) | KDM4EPOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5568394 | 0.78 | KDM4E (0.56) | KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL10172622 | 0.78 | KDM4E (0.56) | KDM4EPOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL9026168 | 0.77 | KDM4E (0.58) | KDM4EPOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL21331813 | 0.77 | KDM4E (0.55) | KDM4EPOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL18704309 | 0.77 | LMNA (0.54) | KDM4EPOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11351745 | 0.77 | ALDH1A1 (0.58) | KDM4EALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL11269746 | 0.77 | HPGDS (0.61) | KDM4EPOLBALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140349989-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | ALZHEIMER'S INSTITUTE OF AMERICA (US) | 2014-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140349989-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | NFATC1, CD4, CD47 | KDM4E 2413/4885POLB 4179/4885ALDH1A1 562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.