INPP5B — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL5606360	1.00	2/20
SCHEMBL18045513	1.00	2/20
SCHEMBL18045518	0.74	2/20
SCHEMBL4186925	0.71	2/20
SCHEMBL2573126	0.70	2/20
SCHEMBL8386747	0.68	2/20
SCHEMBL9701188	0.68	2/20
SCHEMBL8389196	0.67	2/20
SCHEMBL11311872	0.65	2/20
SCHEMBL842728	0.63	2/20
SCHEMBL5667875	0.63	2/20
SCHEMBL18045507	0.63	2/20
SCHEMBL11574488	0.62	2/20
SCHEMBL18045512	0.62	2/20
SCHEMBL9645945	0.61	2/20
SCHEMBL8384614	0.61	2/20
SCHEMBL8384709	0.61	2/20
SCHEMBL4186085	0.60	2/20
SCHEMBL522291	0.59	2/20
SCHEMBL2220467	0.59	2/20

Clinical trials — most relevant to INPP5B by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Effect of the Preoperative Oral Carbohydrate Attenuating Immediate Postoperative Insulin Resistance on PI3K Dependent Signaling Pathway	PHASE4	COMPLETED
Efficacy of Lithium Against Chemotherapy Induced Neutropenia in Breast Cancer Patients	PHASE3	COMPLETED
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
Etidronate for Arterial Calcifications Due to Deficiency in CD73 (ACDC)	PHASE2	COMPLETED
Study Evaluating Toxicity & Efficacy of Lenalidomide(Revlimid®)in Chemotherapy-Naïve AIPC Patients	PHASE2	COMPLETED
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients	PHASE1/PHASE2	WITHDRAWN
Effects of Lithium Therapy on Blood-based Therapeutic Targets in Parkinson's Disease.	PHASE1	COMPLETED
Analysis of Tissues From Patients in Trial of Myo-Inositol to Prevent Lung Cancer	PHASE1	COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides	PHASE1	COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events	nan	COMPLETED
The Study Aims to Investigate the Effects of Oral Inositols on Insulin-resistance in Children With Obesity.	nan	UNKNOWN
Evaluation of Plasma Sphingosine-1-Phosphate as A Diagnostic and Prognostic Biomarkers of Community-Acquired Pneumonia	nan	UNKNOWN
Duality of Lipids: the Athlete's Paradox	nan	COMPLETED
Exome Sequencing for Atypical Femoral Fractures	nan	COMPLETED
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia	nan	RECRUITING
Unraveling Genetics of HypoPhosPhatasia (HPP Genetics)	nan	COMPLETED
Molecular Markers of Human Sperm Function	nan	WITHDRAWN
Partial PTEN Deletion in Breast Cancer	nan	UNKNOWN
Composition & Function of Sarcoplasmic Reticulum in Persons With the Metabolic Syndrome	nan	COMPLETED
Planetary Habitat Simulation: Bone Metabolism Studies	nan	COMPLETED
Vulvodynia: Identification of Potential Relevant Biomarkers	nan	COMPLETED
Studying Phosphorus Metabolism	nan	COMPLETED
Institution of an Italian Multicenter Database of Patients Affected by Diseases of Phosphate Metabolism	nan	NOT_YET_RECRUITING
Hypophosphatemic Rickets in Norway	nan	UNKNOWN
Plaque Calcium Characterization and Ruptured Plaques	nan	UNKNOWN
TSH Receptor Mutations Among a Consanguineous Community	nan	COMPLETED
Prevalence and Risk Factors of Nephrocalcinosis in Children at Sohag University Hospital	nan	UNKNOWN
Effect of Short-Term Exercise Training on ATP Synthesis in Relatives of Type 2 Diabetic Humans	nan	COMPLETED
Combining Gene Variants to Improve Risk Prediction for Metabolic (Dysfunction)- Associated Fatty Liver Disease and Its Progression to Cirrhosis in Indian Individuals With Type 2 Diabetes	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a INPP5B binder may also engage these)

Protein	Name	Similarity
Q8K337	—	1.000	Q8K337 →
D3ZGS3	—	0.998	D3ZGS3 →
Q6NVF0	—	0.997	Q6NVF0 →
Q01968	—	0.996	Q01968 →
Q2I6J0	—	0.996	Q2I6J0 →
P25799	—	0.995	P25799 →
B0R0W9	—	0.994	B0R0W9 →
Q9H1H9	—	0.994	Q9H1H9 →
KDM5D	Lysine-specific demethylase 5D	0.994	landscape →
KAT8	Histone acetyltransferase KAT8	0.993	landscape →
NFKB1	Nuclear factor NF-kappa-B p105 subunit	0.993	landscape →
P70600	—	0.992	P70600 →
Q5XUN4	—	0.992	Q5XUN4 →
Q6P158	—	0.992	Q6P158 →
O14827	—	0.992	O14827 →
P10686	—	0.992	P10686 →
Q00495	—	0.992	Q00495 →
O12990	—	0.992	O12990 →
PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.992	landscape →
Q8BWR4	—	0.992	Q8BWR4 →
KDM5B	Lysine-specific demethylase 5B	0.992	landscape →
Q62077	—	0.991	Q62077 →
A0A2R8QPS5	—	0.991	A0A2R8QPS5 →
A3KMI0	—	0.991	A3KMI0 →
P41230	—	0.991	P41230 →
Q6GM53	—	0.991	Q6GM53 →
Q22070	—	0.991	Q22070 →
P52332	—	0.991	P52332 →
Q5XHF8	—	0.991	Q5XHF8 →
B4NBB0	—	0.991	B4NBB0 →