Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.54 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.52 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.52 |
| ▸ | KCNMA1 | Q12791 | 10/20 | 0.47 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30186073 | 1.00 | LRRK2 (0.54) | LRRK2IMPDH2IMPDH1KCNMA1PSMD14 | |
| SCHEMBL29112310 | 0.76 | LRRK2 (0.57) | LRRK2IMPDH2IMPDH1CDK9 | |
| SCHEMBL19606882 | 0.75 | PSMD14 (0.39) | LRRK2IMPDH2IMPDH1KCNMA1PSMD14 | |
| SCHEMBL3887037 | 0.74 | CSNK2A1 (0.46) | LRRK2KCNMA1PSMD14GRM4 | |
| SCHEMBL11167116 | 0.74 | PSMD14 (0.41) | LRRK2KCNMA1PSMD14GRM4 | |
| SCHEMBL30052607 | 0.73 | IMPDH2 (0.42) | LRRK2IMPDH2IMPDH1CCNT1CDK9 | |
| SCHEMBL31586447 | 0.73 | IMPDH2 (0.42) | LRRK2IMPDH2IMPDH1CCNT1CDK9 | |
| SCHEMBL19273386 | 0.73 | KCNMA1 (0.41) | LRRK2KCNMA1PSMD14GRM4 | |
| SCHEMBL31588050 | 0.72 | PARP1 (0.50) | LRRK2IMPDH2IMPDH1 | |
| SCHEMBL10254 | 0.72 | PARP1 (0.50) | LRRK2IMPDH2IMPDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417133-A1 | COMPOUNDS AND METHODS FOR ANTIVIRAL TREATMENT | PTC Therapeutics, Inc. (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117935-A1 | COMPOUNDS AND METHODS FOR ANTIVIRAL TREATMENT | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |