KYAT3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2143232	1.00	4/20
SCHEMBL6763274	1.00	4/20
Hydrochloric Acid (SCHEMBL16612973)	0.97	4/20
SCHEMBL3778745	0.81	4/20
SCHEMBL6763945	0.80	4/20
SCHEMBL6763345	0.79	4/20
SCHEMBL6763381	0.79	4/20
SCHEMBL6763411	0.79	4/20
SCHEMBL6763507	0.79	4/20
SCHEMBL6763263	0.78	4/20
SCHEMBL6763409	0.78	4/20
SCHEMBL6763492	0.78	4/20
SCHEMBL6763400	0.77	4/20
SCHEMBL6763363	0.76	4/20
SCHEMBL3775187	0.75	4/20
SCHEMBL6763386	0.74	4/20
SCHEMBL6832224	0.74	4/20
SCHEMBL6832283	0.74	4/20
SCHEMBL6763281	0.74	4/20
SCHEMBL3774185	0.73	4/20

Clinical trials — most relevant to KYAT3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Theca Cell Function in Adolescents With Polycystic Ovary Syndrome (PCOS)	PHASE3	COMPLETED
Folate Rechallenge	PHASE2	COMPLETED
Magnetic Resonance Imaging (MRI) With Hyperpolarized Pyruvate (13C) as Diagnostic Tool in Advanced Prostate Cancer	PHASE2	SUSPENDED
A Phase Ib/II Clinical Study of AK127 in Combination With AK112 in Patients With Advanced Solid Tumors	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
Diclofenac Dose Response Study	PHASE1	RECRUITING
Tolerability of Enteral NAC in Infants	PHASE1	NOT_YET_RECRUITING
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers	PHASE1	COMPLETED
Knockdown of HSD17B13 mRNA, Pharmacokinetics, Safety, and Tolerability, of AZD7503 in Non-Alcoholic Fatty Liver Disease	PHASE1	COMPLETED
Therapeutic Ketogenic Diet in Anorexia Nervosa	nan	RECRUITING
Androgens and NAFLD Longitudinal Cohort Study	nan	RECRUITING
Evaluating Response to Vitamin D3 and K2 Supplementation in Healthcare Personnel	nan	RECRUITING
VIRTUUS Children's Study	nan	ACTIVE_NOT_RECRUITING
Lysine Oxidation in Response to Arginine Supplementation	nan	COMPLETED
Nutritional Impacts of Palynziq on Patients With Phenylketonuria (PKU)	nan	RECRUITING
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
An Assessment of Cognitive Function in Irritable Bowel Syndrome	nan	UNKNOWN
Omics Profiling of Weight Loss With Bariatric Surgery	nan	COMPLETED
Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans	nan	ACTIVE_NOT_RECRUITING
Clinical and Laboratory Study of Methylmalonic Acidemia	nan	RECRUITING
Genetic and Metabolic Disease in Children	nan	RECRUITING
Correlation Between EGFR Mutation Using cfDNAs and Circulating Tumor Cells in Patients With NSCLC	nan	UNKNOWN
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Acute Glycine Pharmacodynamic Study	nan	COMPLETED
Lysine Requirements During Lactation	nan	COMPLETED
Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis	nan	RECRUITING
Screening of IDH1 and IDH2 Gene Mutations in Adult Acute Myeloid Leukemia for Possible Targeted Therapy	nan	UNKNOWN
Alternative Substrates in the Critically Ill Subject	nan	COMPLETED
Genetic-specific Effects of Fructose on Liver Lipogenesis	nan	COMPLETED
Exploring the Molecular Basis to Healthy Obesity: The Diabetes Risk Assessment Study	nan	COMPLETED
The Intervention Study of Dietary Intake on Energy Expenditure	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a KYAT3 binder may also engage these)

Protein	Name	Similarity
Q0P5G4	—	0.994	Q0P5G4 →
Q71RI9	—	0.990	Q71RI9 →
Q58FK9	—	0.988	Q58FK9 →
Q7T3E5	—	0.983	Q7T3E5 →
Q17CS8	—	0.974	Q17CS8 →
Q5E9N4	—	0.973	Q5E9N4 →
AADAT	Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	0.971	landscape →
Q07262	—	0.968	Q07262 →
KYAT1	Kynurenine--oxoglutarate transaminase 1	0.968	landscape →
Q64602	—	0.967	Q64602 →
P18485	—	0.965	P18485 →
Q9STR4	—	0.965	Q9STR4 →
P23599	—	0.965	P23599 →
Q43309	—	0.964	Q43309 →
Q8BTY1	—	0.964	Q8BTY1 →
Q9SIE1	—	0.964	Q9SIE1 →
Q9M2Y8	—	0.963	Q9M2Y8 →
P37821	—	0.963	P37821 →
Q37001	—	0.962	Q37001 →
Q9SAR0	—	0.962	Q9SAR0 →
Q00379	—	0.961	Q00379 →
Q9MB95	—	0.961	Q9MB95 →
P23279	—	0.960	P23279 →
Q08415	—	0.960	Q08415 →
Q06402	—	0.960	Q06402 →
Q9WVM8	—	0.959	Q9WVM8 →
P31531	—	0.959	P31531 →
E9L7A5	—	0.958	E9L7A5 →
Q9T065	—	0.957	Q9T065 →
O88813	—	0.957	O88813 →