Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMEL1 | Q495T6 | 12/20 | 0.53 |
| ▸ | MME | P08473 | 7/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1912590 | 0.88 | MMEL1 (0.67) | MMEL1MMEACE | |
| SCHEMBL1519856 | 0.86 | CTSL (0.62) | MMEL1MMECTSLFFAR2ACE | |
| SCHEMBL742226 | 0.86 | CTSL (0.62) | MMEL1MMECTSLFFAR2ACE | |
| SCHEMBL742227 | 0.86 | CTSL (0.62) | MMEL1MMECTSLFFAR2ACE | |
| SCHEMBL740615 | 0.83 | ATM (0.49) | MMEL1MMECTSLATM | |
| SCHEMBL740616 | 0.83 | ATM (0.49) | MMEL1MMECTSLATM | |
| SCHEMBL1519890 | 0.83 | ATM (0.49) | MMEL1MMECTSLATM | |
| SCHEMBL2878307 | 0.81 | MMEL1 (0.67) | MMEL1MMEATM | |
| SCHEMBL740779 | 0.80 | MME (0.56) | MMEL1MMECTSLFFAR2ACE | |
| SCHEMBL5966601 | 0.80 | MME (0.56) | MMEL1MMECTSLFFAR2ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435409-A1 | SUBSTITUTED AMINOPROPIONIC DERIVATIVES AS NEPRILYSIN INHIBITORS | Novartis AG (CH) | 2012-04-04 | — | — | EP | disclosed |
| WO-2010136493-A1 | SUBSTITUTED AMINOPROPIONIC DERIVATIVES AS NEPRILYSIN INHIBITORS | NOVARTIS AG (CH) | 2010-12-02 | — | — | WO | disclosed |