MPDU1

Mannose-P-dolichol utilization defect 1 protein

0 patent compounds predicted against MPDU1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Germline variants in MPDU1 on Sugi Variant → ClinVar classifications, population frequency, and predictor agreement (AlphaMissense, SaProt, REVEL) Full MPDU1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

Clinical trials — most relevant to MPDU1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Comparison of Pharmacokinetic, Safety, Tolerability of Alpha-1 MP and Prolastin In Alpha1-antitrypsin Deficient Adults	PHASE3	COMPLETED
24-Week Study to Assess the PD, Safety, Tolerability, and PK of GLM101 in Participants With PMM2-CDG	PHASE2	COMPLETED
Open-Label Extension Study to Assess GLM101 in PMM2-CDG Patients	PHASE2	ENROLLING_BY_INVITATION
The Effect of Triheptanoin on Fatty Acid Oxidation and Exercise Tolerance in Patients With Glycogenoses	PHASE2	COMPLETED
RGX-111 Gene Therapy in Patients With MPS I	PHASE1/PHASE2	SUSPENDED
A Study Evaluating the Safety and Pharmacokinetics of Aldurazyme® (Laronidase) in MPS I Patients Less Than 5 Years Old	PHASE2	COMPLETED
A Clinical Study Evaluating the Safety, Tolerability, and Initial Efficacy of JWK008 in Patients With Mucopolysaccharidosis Type I	PHASE1	RECRUITING
The Natural History of Alpha-Mannosidosis	nan	COMPLETED
Biomarker for Mannosidosis Disease (BioMannosidosis)	nan	WITHDRAWN
Using D-Galactose as a Food Supplement in Congenital Disorders of Glycosylation	nan	COMPLETED
Biomarker for Mucolipidosis Disorder Type I, II, III, IV (BioML)	nan	WITHDRAWN
Biomarker for Hurler Disease (BioHurler)	nan	WITHDRAWN
Glycosylation in Patients With Galactosaemia	nan	COMPLETED
Incidence and Consequences of Disorders of Glycosylation in Patients With Conotruncal and Septal Heart Defects	nan	UNKNOWN
Biomarker for Sanfilippo Type A-B-C-D Disease (BioSanfilippo)	nan	WITHDRAWN
Mucopolysaccharidosis I (MPS I) Registry	nan	COMPLETED
Registry Gangliosidoses	nan	UNKNOWN
Characterization of the Patient Population With Galactosialidosis	nan	COMPLETED
Clinical Biomarkers in Alpha-mannosidosis	nan	COMPLETED
Evaluation of Blood Brain Barrier Integrity and Structural Abnormalities in MPS IIIB Patients Using Multimodal Magnetic Resonance Imaging	nan	COMPLETED
Natural History Study of Patients With Mucopolysaccharidosis Type IIIB (MPS IIIB, Sanfilippo Syndrome Type B)	nan	COMPLETED
Detection of Pompe Disease in Adult Patients With Myopathies of Uncertain Origin or With Asymptomatic Hyper-CK-emia	nan	UNKNOWN
The Natural History of Sialidosis Type I	nan	RECRUITING
A Retrospective Chart Review of Deceased Patients With Mucopolysaccharidosis Type IIIB	nan	COMPLETED
Longitudinal Studies of the Glycoproteinoses	nan	COMPLETED
Screening of Lysosomal Storage Disorders Diseases in Minority Groups	nan	UNKNOWN
Natural History of Glycosphingolipid Storage Disorders and Glycoprotein Disorders	nan	RECRUITING
Genetic Studies of Lysosomal Storage Disorders	nan	ENROLLING_BY_INVITATION
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes	nan	RECRUITING
Effect of Primary Non-surgical Endodontic Therapy on Glycaemic Control in Type 2 Diabetic Patients With Asymptomatic Apical Periodontitis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a MPDU1 binder may also engage these)

Protein	Name	Similarity
Q60441	—	0.994	Q60441 →
Q9R0Q9	—	0.987	Q9R0Q9 →
P57791	—	0.912	P57791 →
Q9CY27	—	0.912	Q9CY27 →
Q8VDI9	—	0.911	Q8VDI9 →
Q9DAX2	—	0.910	Q9DAX2 →
Q64232	—	0.907	Q64232 →
P0CK96	—	0.906	P0CK96 →
SLC75A1	Major facilitator superfamily domain-containing protein 10	0.905	landscape →
TECR	Very-long-chain enoyl-CoA reductase	0.905	landscape →
ERG28	Ergosterol biosynthetic protein 28 homolog	0.904	landscape →
Q3ZCD7	—	0.904	Q3ZCD7 →
Q95JH2	—	0.903	Q95JH2 →
Q9ERY9	—	0.903	Q9ERY9 →
Q99943	—	0.903	Q99943 →
Q95JH0	—	0.902	Q95JH0 →
Q96H72	—	0.902	Q96H72 →
Q0P5M9	—	0.902	Q0P5M9 →
B0BMW8	—	0.901	B0BMW8 →
D2HKB0	—	0.900	D2HKB0 →
B2KI79	—	0.899	B2KI79 →
Q91VM4	—	0.899	Q91VM4 →
RCE1	CAAX prenyl protease 2	0.899	landscape →
Q4V899	—	0.898	Q4V899 →
Q9H6U8	—	0.898	Q9H6U8 →
P52875	—	0.897	P52875 →
SPNS2	Sphingosine-1-phosphate transporter SPNS2	0.897	landscape →
Q8BWB6	—	0.897	Q8BWB6 →
B1MTH4	—	0.897	B1MTH4 →
Q5RDC9	—	0.896	Q5RDC9 →