Endothelin

Endothelin

SCHEMBL29352622

CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNMA1 Q12791 1/20 0.53
KCNMB4 Q86W47 1/20 0.53
RXFP1 Q9HBX9 1/20 0.50
RXFP4 Q8TDU9 5/20 0.48
RXFP3 Q9NSD7 5/20 0.48
CACNA1B Q00975 1/20 0.47
SSTR2 P30874 2/20 0.47
SSTR5 P35346 2/20 0.47
FLT1 P17948 1/20 0.46
TET2 Q6N021 1/20 0.45
TET1 Q8NFU7 1/20 0.45
PCSK9 Q8NBP7 1/20 0.45
TP53 P04637 2/20 0.45
MDM2 Q00987 2/20 0.45
ITGB3 P05106 1/20 0.45
ITGAV P06756 1/20 0.45
BECN1 Q14457 2/20 0.44
SHH Q15465 1/20 0.44
MSTN O14793 1/20 0.44
SSTR4 P31391 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29379999 0.97 KCNMA1 (0.55) KCNMA1KCNMB4RXFP1RXFP4RXFP3
Endothelin SCHEMBL29403065 0.94 RXFP1 (0.55) KCNMA1KCNMB4RXFP1RXFP4RXFP3
Endothelin SCHEMBL21644373 0.94 RXFP1 (0.55) KCNMA1KCNMB4RXFP1RXFP4RXFP3
SCHEMBL26929028 0.94 KCNMA1 (0.55) KCNMA1KCNMB4RXFP1RXFP4RXFP3
SCHEMBL29403556 0.94 KCNMA1 (0.55) KCNMA1KCNMB4RXFP1RXFP4RXFP3
SCHEMBL29484633 0.93 KCNMA1 (0.55) KCNMA1KCNMB4RXFP1RXFP4RXFP3
SCHEMBL29921568 0.90 KCNMA1 (0.54) KCNMA1KCNMB4RXFP1RXFP4RXFP3
SCHEMBL29661263 0.88 KCNMA1 (0.55) KCNMA1KCNMB4RXFP1SSTR2SSTR5
SCHEMBL21412615 0.81 IL23R (0.58) KCNMA1KCNMB4RXFP3SSTR2SSTR5
SCHEMBL21412610 0.81 IL23R (0.58) KCNMA1KCNMB4RXFP3SSTR2SSTR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 876 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4718076-A2 WORKFLOW FOR RISK ASSESSMENT AND PATIENT MANAGEMENT USING PROCALCITONIN AND MIDREGIONAL-PROADRENOMEDULLIN B.R.A.H.M.S GmbH (DE) 2026-04-01 EP claimed
EP-4709477-A2 COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF MICROVASCULATURE DYSFUNCTION AND RELATED DISEASES The Texas A&M University System (US) 2026-03-18 EP claimed
EP-3729101-B1 WORKFLOW FOR RISK ASSESSMENT AND PATIENT MANAGEMENT USING PROCALCITONIN AND PROADRENOMEDULLIN BRAHMS GMBH (DE) 2026-03-18 EP claimed
US-20260069216-A1 MULTIPLE PARTIALLY REDUNDANT BIOMETRIC SENSING DEVICES POLTORAK TECH LLC (US) 2026-03-12 US claimed
US-12564615-B2 Treatment method for cardiac hypertrophy IMAM ABDULRAHMAN BIN FAISAL UNIVERSITY (SA) 2026-03-03 US claimed
EP-4430037-B1 ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF GENZYME CORP (US) 2025-10-29 EP claimed
EP-4608432-A1 EXTRACRANIAL METHODS FOR FACILITATING CEREBROSPINAL FLUID DRAINAGE Institute for Basic Science (IBS) (KR) 2025-09-03 EP claimed
EP-3809139-B1 METHODS AND COMPOSITIONS FOR ASSESSING LUNG GRAFTS UNIV HEALTH NETWORK (CA) 2025-08-20 EP claimed
US-12385926-B2 MMP-8 as a marker for identifying infectious disease B.R.A.H.M.S GMBH (DE) 2025-08-12 US claimed
WO-2025133663-A1 DIGITAL TISSUE REPAIR MODEL Institut National de la Santé et de la Recherche Médicale (FR) 2025-06-26 WO claimed
US-20230194530-A1 CIRCULATING CARDIOVASCULAR BIOMARKERS AND VASCULAR STABILIZING THERAPY UNIVERSITY HEALTH NETWORK (CA) 2023-06-22 US claimed
US-20230157264-A1 ANIMAL MODELS AND THERAPEUTIC MOLECULES KYMAB LIMITED (GB) 2023-05-25 US claimed
EP-4183867-A1 METHOD FOR PRODUCING CARDIOMYOCYTE CELL MASS Kaneka Corporation (JP) 2023-05-24 EP claimed
US-11584792-B2 Antibody therapies and methods for treating coronavirus infection TRUSTEES OF BOSTON UNIVERSITY (US) 2023-02-21 US claimed
US-20230028168-A1 Modified Relaxin Polypeptides and Their Uses AMBRX, INC. 2023-01-26 US claimed
US-11523981-B2 Cosmetic composition and its use, dermocosmetic formulation LUXBIOTECH FARMACÊUTICA LTDA (BR) 2022-12-13 US claimed
US-20220218701-A1 COMPOSITIONS AND METHODS COMPRISING ENDOTHELIN A RECEPTOR ANTAGONISTS AND ANDROGEN THERAPIES THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS 2022-07-14 US claimed
CN-114468274-A Application of traditional Chinese medicine composition in food for assisting in relieving hypertension, nutritional powder and preparation method of nutritional powder 特康药业集团有限公司 2022-05-13 CN claimed
US-20220144939-A1 ANTIBODY THERAPIES AND METHODS FOR TREATING CORONAVIRUS INFECTION TRUSTEES OF BOSTON UNIVERSITY (US) 2022-05-12 US claimed
WO-2022081792-A1 ANTIBODY THERAPIES AND METHODS FOR TREATING CORONAVIRUS INFECTION TRUSTEES OF BOSTON UNIVERSITY (US) 2022-04-21 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12564615-B2 Treatment method for cardiac hypertrophy TNNT2, ADIPOR1, AGTR1 KCNMA1 2909/4885KCNMB4 3329/4885RXFP1 713/4885
US-20230028168-A1 Modified Relaxin Polypeptides and Their Uses RXFP1, RXFP2, RXFP4 KCNMA1 2678/4885KCNMB4 1714/4885RXFP1 1/4885
US-20260069216-A1 MULTIPLE PARTIALLY REDUNDANT BIOMETRIC SENSING DEVICES VEGFA, KDR, TGFBR1 KCNMA1 2229/4885KCNMB4 2025/4885RXFP1 12/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.