MT-ND4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Auraptene (SCHEMBL2535029)	1.00	5/20
Auraptene (SCHEMBL2535034)	1.00	5/20
SCHEMBL1754960	0.80	4/20
SCHEMBL8491443	0.56	4/20
SCHEMBL8489900	0.52	4/20
SCHEMBL8489907	0.52	4/20
SCHEMBL8492838	0.52	4/20
SCHEMBL8492845	0.52	4/20
SCHEMBL8489902	0.51	4/20
SCHEMBL8489908	0.51	4/20
SCHEMBL8491154	0.51	4/20
SCHEMBL8491160	0.51	4/20
SCHEMBL8491619	0.50	4/20
SCHEMBL8491624	0.50	4/20
SCHEMBL8491634	0.50	4/20
Rotenone (SCHEMBL42253)	1.00	3/20
Rotenone (SCHEMBL5490007)	0.98	3/20
Rotenone (SCHEMBL7142434)	0.95	3/20
Rotenone (SCHEMBL8386940)	0.93	3/20
Rotenone (SCHEMBL43319)	0.83	3/20

Clinical trials — most relevant to MT-ND4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease	PHASE3	COMPLETED
A Phase 3, Multicenter, Randomized, Double-Masked, Sham-Controlled Clinical Trial for Leber's Hereditary Optic Neuropathy (LHON) Associated With ND4 Mutation	PHASE3	ACTIVE_NOT_RECRUITING
A Single Intravitreal Injection of rAAV2-ND4 for the Treatment of Leber's Hereditary Optic Neuropathy	PHASE2/PHASE3	UNKNOWN
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy	PHASE2	ACTIVE_NOT_RECRUITING
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Efficacy and Safety Study of Bilateral IVT Injection of GS010 at Two Dose Levels in LHON Patients	PHASE2	RECRUITING
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?	PHASE1	UNKNOWN
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection	nan	COMPLETED
The Natural History of Mitochondrial Diseases	nan	RECRUITING
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases	nan	RECRUITING
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.	nan	UNKNOWN
Calf Muscle Strength in Mitochondrial Diseases	nan	COMPLETED
Diagnostic Odyssey Survey 2	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Survey on Supplement Use in Mitochondrial Disease	nan	COMPLETED
EPI-743 for Mitochondrial Respiratory Chain Diseases	nan	NO_LONGER_AVAILABLE
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
The Impact of Mitochondrial Dysfunction on Human Bone Cell Metabolism and Remodelling	nan	ACTIVE_NOT_RECRUITING
Efficacy Study of Gene Therapy for The Treatment of Acute LHON Onset Within Three Months	nan	UNKNOWN
mtDNA Mutation Load Analysis in Mesoangioblasts	nan	RECRUITING
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
Mitoquines in COPD	nan	UNKNOWN
Natural History Study - Mitochondrial Disease	nan	RECRUITING
Red Light Ptosis Proof-of-Concept	nan	UNKNOWN
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a MT-ND4 binder may also engage these)

Protein	Name	Similarity
P03907	—	1.000	P03907 →
Q9T9W6	—	1.000	Q9T9W6 →
P03909	—	1.000	P03909 →
Q2I3F2	—	1.000	Q2I3F2 →
O03204	—	1.000	O03204 →
P03911	—	1.000	P03911 →
P92698	—	1.000	P92698 →
P41308	—	1.000	P41308 →
Q2I3G5	—	1.000	Q2I3G5 →
P41298	—	1.000	P41298 →
Q38PR3	—	1.000	Q38PR3 →
O21334	—	1.000	O21334 →
Q96068	—	1.000	Q96068 →
Q598S9	—	1.000	Q598S9 →
P03906	—	1.000	P03906 →
P24975	—	0.999	P24975 →
Q9ZZY2	—	0.998	Q9ZZY2 →
A8DQI9	—	0.998	A8DQI9 →
Q95917	—	0.998	Q95917 →
Q3L6Y5	—	0.998	Q3L6Y5 →
Q34878	—	0.997	Q34878 →
Q85DA7	—	0.997	Q85DA7 →
P48655	—	0.997	P48655 →
O79881	—	0.996	O79881 →
P38601	—	0.996	P38601 →
O78755	—	0.996	O78755 →
Q576B5	—	0.995	Q576B5 →
Q36458	—	0.995	Q36458 →
P92668	—	0.995	P92668 →
Q9ZZ58	—	0.995	Q9ZZ58 →