NDUFA11 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL15258558	0.76	8/20
SCHEMBL12362713	0.77	7/20
SCHEMBL15080621	0.77	7/20
SCHEMBL12362702	0.73	7/20
SCHEMBL14351066	0.69	7/20
SCHEMBL12226742	0.61	7/20
SCHEMBL12362734	0.60	6/20
SCHEMBL12362700	0.57	6/20
SCHEMBL13973668	0.47	6/20
SCHEMBL16316892	0.47	6/20
Auraptene (SCHEMBL2535029)	1.00	5/20
Auraptene (SCHEMBL2535034)	1.00	5/20
Umbelliprenin (SCHEMBL18265478)	0.98	5/20
SCHEMBL12362712	0.80	5/20
SCHEMBL14437596	0.57	5/20
SCHEMBL14437626	0.57	5/20
SCHEMBL14515244	0.57	5/20
SCHEMBL13743063	0.43	5/20
SCHEMBL18197750	0.41	5/20
SCHEMBL18265492	0.74	4/20

Clinical trials — most relevant to NDUFA11 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease	PHASE3	COMPLETED
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy	PHASE2	ACTIVE_NOT_RECRUITING
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease	PHASE2	COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)	PHASE1/PHASE2	NOT_YET_RECRUITING
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?	PHASE1	UNKNOWN
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
The Natural History of Mitochondrial Diseases	nan	RECRUITING
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
Diagnostic Odyssey Survey 2	nan	COMPLETED
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection	nan	COMPLETED
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases	nan	RECRUITING
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip	nan	COMPLETED
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.	nan	UNKNOWN
Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Acute Infection in Mitochondrial Disease: Metabolism, Infection and Immunity	nan	RECRUITING
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders	nan	COMPLETED
The International Registry for Leigh Syndrome	nan	RECRUITING
Ccf mtDNA as a Neurodegenerative Biomarker	nan	UNKNOWN
Coenzyme Q10 Plus NADH Supplementation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis	nan	COMPLETED
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction	nan	COMPLETED
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Assessing the Role of Mitochondrial Dysfunction in Primary Progressive Multiple Sclerosis	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a NDUFA11 binder may also engage these)

Protein	Name	Similarity
Q0MQC0	—	1.000	Q0MQC0 →
Q0MQB8	—	1.000	Q0MQB8 →
Q0MQB9	—	1.000	Q0MQB9 →
Q9D8B4	—	1.000	Q9D8B4 →
Q8HXG6	—	0.998	Q8HXG6 →
Q80W89	—	0.997	Q80W89 →
P25710	—	0.985	P25710 →
Q9S837	—	0.983	Q9S837 →
Q54QM0	—	0.982	Q54QM0 →
O48528	—	0.982	O48528 →
Q9UUF4	—	0.979	Q9UUF4 →
Q751T2	—	0.978	Q751T2 →
P32897	—	0.977	P32897 →
Q9VN13	—	0.976	Q9VN13 →
Q9ZV24	—	0.975	Q9ZV24 →
B6IJ52	—	0.975	B6IJ52 →
Q6PCS6	—	0.975	Q6PCS6 →
Q96I45	—	0.975	Q96I45 →
Q3T0M2	—	0.974	Q3T0M2 →
Q9N4K0	—	0.974	Q9N4K0 →
P63030	—	0.974	P63030 →
Q9HFF0	—	0.974	Q9HFF0 →
P53721	—	0.974	P53721 →
Q12029	—	0.973	Q12029 →
A8E7G5	—	0.973	A8E7G5 →
O94705	—	0.973	O94705 →
Q9CRB8	—	0.973	Q9CRB8 →
Q12328	—	0.973	Q12328 →
P81928	—	0.973	P81928 →
Q5RD16	—	0.973	Q5RD16 →