NDUFA6 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Auraptene (SCHEMBL2535029)	1.00	5/20
Auraptene (SCHEMBL2535034)	1.00	5/20
SCHEMBL11456503	0.71	4/20
SCHEMBL11456504	0.71	4/20
SCHEMBL11457189	0.69	4/20
SCHEMBL11457190	0.69	4/20
SCHEMBL8491443	0.56	4/20
SCHEMBL8489900	0.52	4/20
SCHEMBL8489907	0.52	4/20
SCHEMBL8492838	0.52	4/20
SCHEMBL8492845	0.52	4/20
SCHEMBL8489902	0.51	4/20
SCHEMBL8489908	0.51	4/20
SCHEMBL8491154	0.51	4/20
SCHEMBL8491160	0.51	4/20
SCHEMBL8491619	0.50	4/20
SCHEMBL8491624	0.50	4/20
SCHEMBL8491634	0.50	4/20
SCHEMBL8494171	0.50	4/20
SCHEMBL8494175	0.50	4/20

Clinical trials — most relevant to NDUFA6 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease	PHASE3	COMPLETED
Coenzyme Q10 as a Symptomatic Treatment in Parkinson's Disease	PHASE3	COMPLETED
Effect of Montelukast Versus Co Enzyme in Sepsis	PHASE2/PHASE3	COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)	PHASE1/PHASE2	NOT_YET_RECRUITING
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease	PHASE2	COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy	PHASE2	ACTIVE_NOT_RECRUITING
Parkinson's Disease Treatment With Coenzyme Q10	PHASE2	COMPLETED
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?	PHASE1	UNKNOWN
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
The Natural History of Mitochondrial Diseases	nan	RECRUITING
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection	nan	COMPLETED
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip	nan	COMPLETED
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases	nan	RECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
Assessment of Follicular Fluid Level of Coenzyme Q10 in Women Undergoing ICSI	nan	UNKNOWN
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders	nan	COMPLETED
Nicotinamide Riboside in Ulcerative Colitis	nan	RECRUITING
Q10 Ubiquinol in Autism Spectrum Disorder and in Phelan-McDermid Syndrome.	nan	UNKNOWN
Diagnostic Odyssey Survey 2	nan	COMPLETED
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.	nan	UNKNOWN
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Pharmacokinetic Study on Three Formulations of Coenzyme Q10 With Different Carriers	nan	UNKNOWN
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NDUFA6 binder may also engage these)

Protein	Name	Similarity
Q0MQA4	—	1.000	Q0MQA4 →
Q0MQA3	—	1.000	Q0MQA3 →
Q0MQA5	—	1.000	Q0MQA5 →
Q02366	—	1.000	Q02366 →
Q9CQZ5	—	0.998	Q9CQZ5 →
Q9LHI0	—	0.984	Q9LHI0 →
P42114	—	0.979	P42114 →
Q4WHK3	—	0.976	Q4WHK3 →
Q4IN52	—	0.976	Q4IN52 →
Q8K215	—	0.973	Q8K215 →
A1C9A5	—	0.972	A1C9A5 →
Q9NRP4	—	0.972	Q9NRP4 →
B5XD90	—	0.971	B5XD90 →
P82116	—	0.971	P82116 →
B6GWX1	—	0.970	B6GWX1 →
Q5AX36	—	0.970	Q5AX36 →
Q5BBH7	—	0.970	Q5BBH7 →
A0JPA6	—	0.970	A0JPA6 →
Q6DCS1	—	0.970	Q6DCS1 →
B8JLQ0	—	0.968	B8JLQ0 →
Q9DA03	—	0.968	Q9DA03 →
Q0VCG0	—	0.968	Q0VCG0 →
Q0CVW0	—	0.968	Q0CVW0 →
Q4QQY2	—	0.968	Q4QQY2 →
Q9HD34	—	0.968	Q9HD34 →
A4DA73	—	0.968	A4DA73 →
A2R2Q4	—	0.968	A2R2Q4 →
A5PLG0	—	0.968	A5PLG0 →
Q6TUF2	—	0.967	Q6TUF2 →
Q4SQJ2	—	0.967	Q4SQJ2 →