NDUFAF2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL15258558	0.76	8/20
SCHEMBL12362713	0.77	7/20
SCHEMBL15080621	0.77	7/20
SCHEMBL12362702	0.73	7/20
SCHEMBL14351066	0.69	7/20
SCHEMBL12226742	0.61	7/20
SCHEMBL12362734	0.60	6/20
SCHEMBL12362700	0.57	6/20
SCHEMBL13973668	0.47	6/20
SCHEMBL16316892	0.47	6/20
Auraptene (SCHEMBL2535029)	1.00	5/20
Auraptene (SCHEMBL2535034)	1.00	5/20
Umbelliprenin (SCHEMBL18265478)	0.98	5/20
SCHEMBL12362712	0.80	5/20
SCHEMBL14437596	0.57	5/20
SCHEMBL14437626	0.57	5/20
SCHEMBL14515244	0.57	5/20
SCHEMBL13743063	0.43	5/20
SCHEMBL18197750	0.41	5/20
SCHEMBL18265492	0.74	4/20

Clinical trials — most relevant to NDUFAF2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease	PHASE3	COMPLETED
Coenzyme Q10 as a Symptomatic Treatment in Parkinson's Disease	PHASE3	COMPLETED
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease	PHASE2	COMPLETED
Parkinson's Disease Treatment With Coenzyme Q10	PHASE2	COMPLETED
A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy	PHASE2	ACTIVE_NOT_RECRUITING
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?	PHASE1	UNKNOWN
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
The Natural History of Mitochondrial Diseases	nan	RECRUITING
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases	nan	RECRUITING
Diagnostic Odyssey Survey 2	nan	COMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip	nan	COMPLETED
Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection	nan	COMPLETED
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.	nan	UNKNOWN
Ccf mtDNA as a Neurodegenerative Biomarker	nan	UNKNOWN
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders	nan	COMPLETED
Nicotinamide Riboside in Ulcerative Colitis	nan	RECRUITING
Cardiac Mitochondrial Function in Explanted Human Hearts	nan	UNKNOWN
Q10 Ubiquinol in Autism Spectrum Disorder and in Phelan-McDermid Syndrome.	nan	UNKNOWN
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NDUFAF2 binder may also engage these)

Protein	Name	Similarity
Q32P65	—	1.000	Q32P65 →
Q59J78	—	0.997	Q59J78 →
Q3KQD1	—	0.978	Q3KQD1 →
O48713	—	0.978	O48713 →
Q9NQ50	—	0.978	Q9NQ50 →
P58501	—	0.978	P58501 →
Q8VCE1	—	0.977	Q8VCE1 →
Q9M9M9	—	0.977	Q9M9M9 →
Q5EAW4	—	0.977	Q5EAW4 →
A1XD94	—	0.977	A1XD94 →
Q9ERA6	—	0.977	Q9ERA6 →
A1XD95	—	0.976	A1XD95 →
Q5R5K8	—	0.976	Q5R5K8 →
SMARCC2	SWI/SNF complex subunit SMARCC2	0.976	landscape →
P82925	—	0.976	P82925 →
Q9W1X9	—	0.976	Q9W1X9 →
Q5U2Y6	—	0.976	Q5U2Y6 →
Q96G28	—	0.975	Q96G28 →
Q61733	—	0.975	Q61733 →
Q1L987	—	0.975	Q1L987 →
P83565	—	0.975	P83565 →
Q28E45	—	0.975	Q28E45 →
Q66JD1	—	0.975	Q66JD1 →
Q9D5W4	—	0.975	Q9D5W4 →
Q0VFC7	—	0.975	Q0VFC7 →
Q9VH39	—	0.975	Q9VH39 →
Q7T0S7	—	0.975	Q7T0S7 →
Q0MQ85	—	0.974	Q0MQ85 →
P31399	—	0.974	P31399 →
Q92665	—	0.974	Q92665 →