Pd-0166285

Pd-0166285

SCHEMBL133914

CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

EGFRFGFR1PDGFRBSRC

The experimentally established mechanism targets of Pd-0166285. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR1 known ✓ P11362 9/20 1.00
SRC known ✓ P12931 6/20 1.00
PDGFRB known ✓ P09619 3/20 1.00
EGFR known ✓ P00533 1/20 1.00
RIPK2 O43353 8/20 1.00
NOD2 Q9HC29 8/20 1.00
ACVR1 Q04771 7/20 1.00
WEE1 P30291 4/20 1.00
PDGFRA P16234 3/20 1.00
FGFR2 P21802 2/20 1.00
FGFR4 P22455 2/20 1.00
FGFR3 P22607 2/20 1.00
CHEK1 O14757 1/20 1.00
JAK2 O60674 1/20 1.00
PRKD3 O94806 1/20 1.00
MAP4K4 O95819 1/20 1.00
PAK4 O96013 1/20 1.00
ABL1 P00519 1/20 1.00
NTRK1 P04629 1/20 1.00
LCK P06239 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pd-0166285 SCHEMBL30250248 1.00 FGFR1 (1.00) FGFR1RIPK2NOD2ACVR1SRC
Pd-0166285 SCHEMBL15106017 0.99 FGFR1 (0.98) FGFR1RIPK2NOD2ACVR1SRC
Pd-0166285 SCHEMBL30276696 0.99 FGFR1 (0.98) FGFR1RIPK2NOD2ACVR1SRC
Pd-0166285 SCHEMBL15923205 0.98 FGFR1 (0.97) FGFR1RIPK2NOD2ACVR1SRC
Pd-0166285 SCHEMBL29658286 0.98 FGFR1 (0.97) FGFR1RIPK2NOD2ACVR1SRC
SCHEMBL10108147 0.95 FGFR1 (0.91) FGFR1RIPK2NOD2ACVR1SRC
SCHEMBL10108496 0.94 FGFR1 (0.89) FGFR1RIPK2NOD2ACVR1SRC
SCHEMBL20563458 0.92 RIPK2 (1.00) FGFR1RIPK2NOD2ACVR1SRC
SCHEMBL29498246 0.92 RIPK2 (1.00) FGFR1RIPK2NOD2ACVR1SRC
SCHEMBL10102543 0.90 FGFR1 (0.86) FGFR1RIPK2NOD2ACVR1SRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 521 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026106952-A1 METHODS FOR TREATING CONGENITAL DISORDERS OF GLYCOSYLATION CDG CARE (US) 2026-05-21 WO claimed
US-20250387643-A1 METHODS AND APPARATUS FOR APPLYING TUMOR TREATING FIELDS COMBINED WITH PERSONALIZED ULTRA-FRACTIONATED STEREOTACTIC ADAPTIVE RADIOTHERAPY THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2025-12-25 US claimed
US-20250360129-A1 COMPOSITIONS AND METHODS OF USING TYROSINE KINASE INHIBITORS UNIV YALE (US) 2025-11-27 US claimed
EP-3250192-B1 COMPOSITIONS AND METHODS OF USING TYROSINE KINASE INHIBITORS UNIV YALE (US) 2025-10-08 EP claimed
US-20250302977-A1 ANTIBODY-DRUG CONJUGATES COMPRISING HUMANIZED ANTIBODIES TARGETING UROKINASE TYPE PLASMINOGEN ACTIVATOR RECEPTOR ASSOCIATED PROTEIN (UPARAP) RIGSHOSPITALET (DK) 2025-10-02 US claimed
WO-2025202361-A1 ANTI-GPC1 ANTIBODIES AND USES THEREOF ADCENDO APS (DK) 2025-10-02 WO claimed
US-12420113-B2 Methods and apparatus for applying tumor treating fields combined with personalized ultra-fractionated stereotactic adaptive radiotherapy THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2025-09-23 US claimed
US-20250275946-A1 COMBINATION THERAPY FOR THE TREATMENT OF CANCER UNM RAINFOREST INNOVATIONS (US) 2025-09-04 US claimed
WO-2025151443-A1 ENDOXIFEN FOR TREATMENT OF RARE CANCERS ATOSSA THERAPEUTICS, INC. (US) 2025-07-17 WO claimed
WO-2025111339-A1 TREATMENT OF CANCER WITH A PARG INHIBITOR 858 THERAPEUTICS, INC. (US) 2025-05-30 WO claimed
WO-2021202780-A2 METHODS AND COMPOSITIONS FOR TREATING CANCER ENGINE BIOSCIENCES PTE. LTD. (SG) 2021-10-07 WO claimed
US-20080220497-A1 Modulation of protein functionalities DECIPHERA PHARMACEUTICALS LLC 2008-09-11 US claimed
EP-1907411-A2 MODULATION OF PROTEIN FUNCTIONALITIES Deciphera Pharmaceuticals, LLC. (US) 2008-04-09 EP claimed
EP-1835934-A2 ENZYME MODULATORS AND TREATMENTS Deciphera Pharmaceuticals, LLC (US) 2007-09-26 EP claimed
US-20070078121-A1 Enzyme modulators and treatments DECIPHERA PHARMACEUTICALS, LLC 2007-04-05 US claimed
WO-2007008917-A2 MODULATION OF PROTEIN FUNCTIONALITIES DECIPHERA PHARMACEUTICALS, LLC (US) 2007-01-18 WO claimed
EP-0823908-B1 PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION WARNER LAMBERT CO (US) 2006-11-02 EP claimed
WO-2006071940-A2 ENZYME MODULATORS AND TREATMENTS DECIPHERA PHARMACEUTICALS, LLC (US) 2006-07-06 WO claimed
EP-0823908-A1 PYRIDO 2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION WARNER-LAMBERT COMPANY (US) 1998-02-18 EP claimed
WO-1996034867-A1 PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION WARNER-LAMBERT COMPANY (US) 1996-11-07 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080220497-A1 Modulation of protein functionalities C1QBP, SERPINA6, CD2BP2 FGFR1 4698/4885SRC 2604/4885PDGFRB 3462/4885
US-20070078121-A1 Enzyme modulators and treatments ABL1, ABL2, LCK FGFR1 118/4885SRC 9/4885PDGFRB 16/4885
US-20250387643-A1 METHODS AND APPARATUS FOR APPLYING TUMOR TREATING FIELDS COMBINED WITH PERSONALIZED ULTRA-FRACTIONATED STEREOTACTIC ADAPTIVE RADIOTHERAPY IFNAR1, IFNG, PDCD1 FGFR1 1135/4885SRC 1885/4885PDGFRB 1333/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.