Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 9/20 | 1.00 |
| ▸ | KEAP1 | Q14145 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.87 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.87 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.87 |
| ▸ | MBOAT4 | Q96T53 | 4/20 | 0.83 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.83 |
| ▸ | USP7 | Q93009 | 2/20 | 0.83 |
| ▸ | USP2 | O75604 | 1/20 | 0.83 |
| ▸ | STAT3 | P40763 | 1/20 | 0.83 |
| ▸ | CCR6 | P51684 | 1/20 | 0.74 |
| ▸ | RORC | P51449 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bardoxolone SCHEMBL14140295 | 1.00 | NOS2 (1.00) | NOS2KEAP1CYP3A4CYP2C19CYP2C9 | |
| Bardoxolone SCHEMBL7717241 | 1.00 | NOS2 (1.00) | NOS2KEAP1CYP3A4CYP2C19CYP2C9 | |
| Bardoxolone SCHEMBL12447454 | 1.00 | NOS2 (1.00) | NOS2KEAP1CYP3A4CYP2C19CYP2C9 | |
| Bardoxolone SCHEMBL69892 | 1.00 | NOS2 (1.00) | NOS2KEAP1CYP3A4CYP2C19CYP2C9 | |
| Bardoxolone SCHEMBL19236126 | 1.00 | NOS2 (1.00) | NOS2KEAP1CYP3A4CYP2C19CYP2C9 | |
| Bardoxolone SCHEMBL24337284 | 1.00 | NOS2 (1.00) | NOS2KEAP1CYP3A4CYP2C19CYP2C9 | |
| Bardoxolone SCHEMBL13569166 | 1.00 | NOS2 (1.00) | NOS2KEAP1CYP3A4CYP2C19CYP2C9 | |
| Bardoxolone SCHEMBL13827463 | 1.00 | NOS2 (1.00) | NOS2KEAP1CYP3A4CYP2C19CYP2C9 | |
| Bardoxolone SCHEMBL954253 | 1.00 | NOS2 (1.00) | NOS2KEAP1CYP3A4CYP2C19CYP2C9 | |
| Bardoxolone SCHEMBL16248344 | 1.00 | NOS2 (1.00) | NOS2KEAP1CYP3A4CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11919838-B2 | Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17 | Reata Pharmaceuticals Holdings, LLC (US) | 2024-03-05 | — | — | US | disclosed |
| US-11911395-B2 | Methods of treating obesity using antioxidant inflammation modulators | Reata Pharmaceuticals Holdings, LLC (US) | 2024-02-27 | — | — | US | disclosed |
| US-11873320-B2 | 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof | Reata Pharmaceuticals Holdings, LLC (US) | 2024-01-16 | — | — | US | disclosed |
| US-20230285500-A1 | Compositions and Methods for Gene Therapy for Corneal Endothelium Disorders | THE SCHEPENS EYE RESEARCH INSTITUTE, INC. | 2023-09-14 | — | — | US | disclosed |
| US-20230255982-A1 | METHODS OF TREATING COVID-19 USING BARDOXOLONE METHYL OR ANALOGS THEREOF | Reata Pharmaceuticals Holdings, LLC (US) | 2023-08-17 | — | — | US | disclosed |
| US-20220073559-A1 | 2,2-DIFLUOROPROPIONAMIDE DERIVATIVES OF BARDOXOLONE METHYL, POLYMORPHIC FORMS AND METHODS OF USE THEREOF | ABBVIE INC. (US) | 2022-03-10 | — | — | US | disclosed |
| US-20220024862-A1 | ANTIOXIDANT INFLAMMATION MODULATORS: OLEANOLIC ACID DERIVATIVES WITH AMINO AND OTHER MODIFICATIONS AT C-17 | REATA PHARMACEUTICALS, INC. (US) | 2022-01-27 | — | — | US | disclosed |
| US-20210355156-A1 | 2,2-DIFLUOROPROPIONAMIDE DERIVATIVES OF BARDOXOLONE METHYL, POLYMORPHIC FORMS AND METHODS OF USE THEREOF | REATA PHARMACEUTICALS, INC. (US) | 2021-11-18 | — | — | US | disclosed |
| US-11117927-B2 | 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof | REATA PHARMACEUTICALS, INC. | 2021-09-14 | — | — | US | disclosed |
| US-11091430-B2 | Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17 | REATA PHARMACEUTICALS, INC. (US) | 2021-08-17 | — | — | US | disclosed |
| US-20100048911-A1 | ANTIOXIDANT INFLAMMATION MODULATORS: NOVEL DERIVATIVES OF OLEANOLIC ACID | REATA PHARMACEUTICALS, INC. | 2010-02-25 | — | — | US | disclosed |
| US-20090326063-A1 | SYNTHETIC TRITERPENOIDS AND METHODS OF USE IN THE TREATMENT OF DISEASE | REATA PHARMACEUTICALS, INC. | 2009-12-31 | — | — | US | disclosed |
| WO-2009089545-A1 | SYNTHETIC TRITERPENOIDS AND METHODS OF USE IN THE TREATMENT OF DISEASE | REATA PHARMACEUTICALS, INC. (US) | 2009-07-16 | — | — | WO | disclosed |
| WO-2009023845-A2 | COMBINATION THERAPY WITH SYNTHETIC TRITERPENOIDS AND GEMCITABINE | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-02-19 | — | — | WO | disclosed |
| US-20090048205-A1 | COMBINATION THERAPY WITH SYNTHETIC TRITERPENOIDS AND GEMCITABINE | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2009-02-19 | — | — | US | disclosed |
| WO-2008136838-A1 | NOVEL AMIDE DERIVATIVES OF CDDO AND METHODS OF USE THEREOF | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2008-11-13 | — | — | WO | disclosed |
| US-20080261985-A1 | SYNTHESIS AND BIOLOGICAL ACTIVITIES OF NEW TRICYCLIC-BIS-ENONES (TBES) | TRUSTEES OF DARTMOUTH COLLEGE | 2008-10-23 | — | — | US | disclosed |
| US-20080233195-A1 | SYNTHETIC TRITERPENOIDS AND TRICYCLIC-BIS-ENONES FOR USE IN STIMULATING BONE AND CARTILAGE GROWTH | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2008-09-25 | — | — | US | disclosed |
| US-20080234368-A9 | Therapeutic compositions and methods of use | TRUSTEES OF DARTMOUTH COLLEGE | 2008-09-25 | — | — | US | disclosed |
| US-7288568-B2 | Therapeutic compositions and methods of use | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2007-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (16 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11911395-B2 | Methods of treating obesity using antioxidant inflammation modulators | TXNRD2, HMOX1, GPX4 | NOS2 83/4885KEAP1 60/4885CYP3A4 2104/4885 |
| US-20080261985-A1 | SYNTHESIS AND BIOLOGICAL ACTIVITIES OF NEW TRICYCLIC-BIS-ENONES (TBES) | HMOX1, MCL1, HMOX2 | NOS2 7/4885KEAP1 38/4885CYP3A4 68/4885 |
| US-20220073559-A1 | 2,2-DIFLUOROPROPIONAMIDE DERIVATIVES OF BARDOXOLONE METHYL, POLYMORPHIC FORMS AND METHODS OF USE THEREOF | CYP2A13, CYP4B1, CYP4A22 | NOS2 1348/4885KEAP1 1496/4885CYP3A4 86/4885 |
| US-20090326063-A1 | SYNTHETIC TRITERPENOIDS AND METHODS OF USE IN THE TREATMENT OF DISEASE | LIPG, CYP27A1, CYP11B1 | NOS2 378/4885KEAP1 444/4885CYP3A4 752/4885 |
| US-20090048205-A1 | COMBINATION THERAPY WITH SYNTHETIC TRITERPENOIDS AND GEMCITABINE | RABGGTB, BAD, PGGT1B | NOS2 3154/4885KEAP1 1567/4885CYP3A4 1771/4885 |
| US-11919838-B2 | Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17 | IL17A, ALOX15, ALOX12 | NOS2 41/4885KEAP1 59/4885CYP3A4 679/4885 |
| US-20210355156-A1 | 2,2-DIFLUOROPROPIONAMIDE DERIVATIVES OF BARDOXOLONE METHYL, POLYMORPHIC FORMS AND METHODS OF USE THEREOF | CYP2A13, CYP4B1, CYP4A22 | NOS2 1348/4885KEAP1 1496/4885CYP3A4 86/4885 |
| US-20220024862-A1 | ANTIOXIDANT INFLAMMATION MODULATORS: OLEANOLIC ACID DERIVATIVES WITH AMINO AND OTHER MODIFICATIONS AT C-17 | IL17A, ALOX15, ALOX12 | NOS2 41/4885KEAP1 59/4885CYP3A4 679/4885 |
| US-20080234368-A9 | Therapeutic compositions and methods of use | PARK7, SNCA, MGMT | NOS2 386/4885KEAP1 332/4885CYP3A4 4203/4885 |
| US-11091430-B2 | Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17 | IL17A, ALOX15, ALOX12 | NOS2 41/4885KEAP1 59/4885CYP3A4 679/4885 |
| US-20230255982-A1 | METHODS OF TREATING COVID-19 USING BARDOXOLONE METHYL OR ANALOGS THEREOF | CYP17A1, HSD11B2, HSD11B1 | NOS2 471/4885KEAP1 207/4885CYP3A4 1144/4885 |
| US-20100048911-A1 | ANTIOXIDANT INFLAMMATION MODULATORS: NOVEL DERIVATIVES OF OLEANOLIC ACID | ALOX12, NFE2L2, HMOX1 | NOS2 66/4885KEAP1 29/4885CYP3A4 1940/4885 |
| US-11873320-B2 | 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof | CYP2A13, CYP4B1, CYP4A22 | NOS2 1348/4885KEAP1 1496/4885CYP3A4 86/4885 |
| US-20230285500-A1 | Compositions and Methods for Gene Therapy for Corneal Endothelium Disorders | KEAP1, NFE2L2, TFAM | NOS2 540/4885KEAP1 1/4885CYP3A4 4327/4885 |
| US-11117927-B2 | 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof | CYP2A13, CYP4B1, CYP4A22 | NOS2 1348/4885KEAP1 1496/4885CYP3A4 86/4885 |
| US-20080233195-A1 | SYNTHETIC TRITERPENOIDS AND TRICYCLIC-BIS-ENONES FOR USE IN STIMULATING BONE AND CARTILAGE GROWTH | BMP4, BMP2, BMP1 | NOS2 553/4885KEAP1 2672/4885CYP3A4 987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.