SCHEMBL16007828

SCHEMBL16007828

CC(C)(c1csc(-c2ccc(F)cc2)n1)N(C(=O)O)C1CN2CCC1CC2

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NTMT1 Q9BV86 20/20 0.59
UGCG Q16739 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16007827 1.00 NTMT1 (0.59) NTMT1UGCG
Hydrochloric Acid SCHEMBL17504473 0.99 NTMT1 (0.58) NTMT1UGCG
Malic Acid SCHEMBL17504472 0.91 NTMT1 (0.52) NTMT1UGCG
Malic Acid SCHEMBL17504470 0.91 NTMT1 (0.52) NTMT1UGCG
SCHEMBL16933476 0.84 NTMT1 (0.49) NTMT1UGCG
SCHEMBL16933647 0.83 NTMT1 (0.49) NTMT1UGCG
SCHEMBL17504471 0.82 NTMT1 (0.50) NTMT1UGCG
SCHEMBL20687127 0.78 NTMT1 (0.75) NTMT1UGCG
SCHEMBL16933488 0.78 NTMT1 (0.46) NTMT1UGCG
SCHEMBL16933646 0.77 NTMT1 (0.46) NTMT1UGCG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11857512-B2 Pharmaceutical compositions comprising venglustat GENZYME CORPORATION (US) 2024-01-02 US claimed
WO-2021067243-A1 TREHALOSE FORMULATIONS AND USES THEREOF SEELOS THERAPEUTICS, INC. (US) 2021-04-08 WO claimed
US-20160039805-A1 SALT FORMS OF (S)-QUINUCLIDIN-3-YL (2-(2-(4-FLUOROPHENYL)THIAZOL-4-YL)PROPAN-2-YL)CARBAMATE GENZYME CORPORATION (US) 2016-02-11 US claimed
US-20260021126-A1 TREHALOSE FORMULATIONS AND USES THEREOF SEELOS THERAPEUTICS INC (US) 2026-01-22 US disclosed
US-12370204-B2 Trehalose formulations and uses thereof SEELOS THERAPEUTICS, INC. (US) 2025-07-29 US disclosed
EP-3514157-B1 METHOD OF PREPARING GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GENZYME CORP (US) 2023-09-06 EP disclosed
EP-4188381-A1 METHODS FOR REDUCING GLYCOSPHINGOLIPID CONCENTRATION IN BRAIN TISSUE AND METHODS OF TREATMENT OF NEURODEGENERATIVE DISEASES INVOLVING THE SAME Genzyme Corporation (US) 2023-06-07 EP disclosed
US-20220409595-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GENZYME CORPORATION 2022-12-29 US disclosed
US-20220387463-A1 TREHALOSE FORMULATIONS AND USES THEREOF SEELOS THERAPEUTICS, INC. 2022-12-08 US disclosed
WO-2022024062-A1 METHODS FOR REDUCING GLYCOSPHINGOLIPID CONCENTRATION IN BRAIN TISSUE AND METHODS OF TREATMENT OF NEURODEGENERATIVE DISEASES INVOLVING THE SAME GENZYME CORPORATION (US) 2022-02-03 WO disclosed
US-20220016092-A1 METHODS FOR TREATING SYMPTOMS AND DISORDERS ASSOCIATED WITH LYSOSOMAL STORAGE DISEASES GENZYME CORPORATION (US) 2022-01-20 US disclosed
EP-3079695-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS Genzyme Corporation (US) 2016-10-19 EP disclosed
US-20160039805-A1 SALT FORMS OF (S)-QUINUCLIDIN-3-YL (2-(2-(4-FLUOROPHENYL)THIAZOL-4-YL)PROPAN-2-YL)CARBAMATE GENZYME CORPORATION (US) 2016-02-11 US disclosed
US-20160039805-A1 SALT FORMS OF (S)-QUINUCLIDIN-3-YL (2-(2-(4-FLUOROPHENYL)THIAZOL-4-YL)PROPAN-2-YL)CARBAMATE GENZYME CORPORATION (US) 2016-02-11 US disclosed
US-9139580-B2 Glucosylceramide synthase inhibitors GENZYME CORPORATION (US) 2015-09-22 US disclosed
US-9126993-B2 Glucosylceramide synthase inhibitors GENZYME CORPORATION (US) 2015-09-08 US disclosed
US-20150210681-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GENZYME CORPORATION (US) 2015-07-30 US disclosed
WO-2015089067-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GENZYME CORPORATION (US) 2015-06-18 WO disclosed
US-20140371460-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GENZYME CORPORATION 2014-12-18 US disclosed
US-20140255381-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GENZYME CORPORATION (US) 2014-09-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150210681-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GBA1, GBA2, GAA NTMT1 795/4885UGCG 4/4885
US-20160039805-A1 SALT FORMS OF (S)-QUINUCLIDIN-3-YL (2-(2-(4-FLUOROPHENYL)THIAZOL-4-YL)PROPAN-2-YL)CARBAMATE GBA1, GBA2, GALC NTMT1 1228/4885UGCG 6/4885
US-20260021126-A1 TREHALOSE FORMULATIONS AND USES THEREOF TREH, MAN2B1, GAA NTMT1 314/4885UGCG 42/4885
US-20220016092-A1 METHODS FOR TREATING SYMPTOMS AND DISORDERS ASSOCIATED WITH LYSOSOMAL STORAGE DISEASES GAA, GBA1, GALC NTMT1 2471/4885UGCG 84/4885
US-20220409595-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GBA1, GBA2, GAA NTMT1 787/4885UGCG 5/4885
US-20140371460-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GBA1, GBA2, GAA NTMT1 814/4885UGCG 4/4885
US-11857512-B2 Pharmaceutical compositions comprising venglustat SOST, SLC5A1, SLC10A6 NTMT1 649/4885UGCG 60/4885
US-20140255381-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GBA1, GBA2, GAA NTMT1 814/4885UGCG 4/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.