PITRM1

Presequence protease, mitochondrial · Q5JRX3 · PITRM1 on Sugi Atlas →

4,595 patent compounds predicted against PITRM1, 3,715 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL13285827	0.48	6/20
SCHEMBL15386484	0.48	6/20
Talabostat (SCHEMBL393024)	1.00	5/20
Talabostat (SCHEMBL4320843)	1.00	5/20
Talabostat (SCHEMBL6895250)	1.00	5/20
Talabostat (SCHEMBL12185345)	1.00	5/20
Talabostat (SCHEMBL14160935)	1.00	5/20
Talabostat (SCHEMBL14160998)	1.00	5/20
Talabostat (SCHEMBL14160999)	1.00	5/20
SCHEMBL12657193	0.78	5/20
SCHEMBL16079845	0.78	5/20
SCHEMBL16921202	0.78	5/20
SCHEMBL18828991	0.78	5/20
SCHEMBL13073505	0.76	5/20
SCHEMBL13074006	0.76	5/20
SCHEMBL16921201	0.63	5/20
SCHEMBL17591091	0.63	5/20
SCHEMBL19697089	0.58	5/20
SCHEMBL8229510	0.57	5/20
SCHEMBL8288237	0.53	5/20

Clinical trials — most relevant to PITRM1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Management of Retinitis Pigmentosa Via Combination of Wharton's Jelly-derived Mesenchymal Stem Cells and Magnovision	PHASE3	COMPLETED
ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma	PHASE2	COMPLETED
Pioglitazone Therapy Targeting Fatigue in Breast Cancer	PHASE2	RECRUITING
A Phase I Study Of Thymoglobulin In Patients With Relapsed Or Refractory Multiple Myeloma	PHASE1	COMPLETED
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival	PHASE1	UNKNOWN
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D)	EARLY_PHASE1	COMPLETED
Role of Sorcin and Annexin A3 in Breast Cancer Patients	nan	UNKNOWN
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
Diabetic Cardiomyopathy and Heart Failure	nan	WITHDRAWN
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise	nan	COMPLETED
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction	nan	COMPLETED
Mitochondrial Dysfunction in Diabetes	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells	nan	RECRUITING
Predicting Pancreatic Necrosis Using mitDNA	nan	UNKNOWN
Effects of Acute Energy Deficit and Aerobic Exercise on Muscle Quality	nan	COMPLETED
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases	nan	COMPLETED
Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
Autophagy Bladder Cancer	nan	UNKNOWN
Mitochondrial Dysfunction in Phelan-McDermid Syndrome	nan	COMPLETED
Insulin Deprivation on Brain Structure and Function in Humans With Type 1 Diabetes	nan	COMPLETED
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED
Pulmonary Hypertension, Hypoxia and Sickle Cell Disease	nan	COMPLETED
Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants	nan	RECRUITING
Multiple Sclerosis: The Role of Mitochondrial Dysfunction in IR Resistance	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PITRM1 binder may also engage these)

Protein	Name	Similarity
Q5RDG3	—	1.000	Q5RDG3 →
Q28BR5	—	1.000	Q28BR5 →
Q8K411	—	1.000	Q8K411 →
Q7ZVZ6	—	1.000	Q7ZVZ6 →
Q6PF24	—	1.000	Q6PF24 →
Q759T9	—	0.997	Q759T9 →
P48053	—	0.995	P48053 →
Q5B6H7	—	0.995	Q5B6H7 →
Q6CWW6	—	0.994	Q6CWW6 →
Q4IA56	—	0.991	Q4IA56 →
Q4WP38	—	0.991	Q4WP38 →
Q2UGN1	—	0.990	Q2UGN1 →
Q6C0U8	—	0.989	Q6C0U8 →
Q7S7C0	—	0.988	Q7S7C0 →
Q9V9E3	—	0.987	Q9V9E3 →
P32898	—	0.987	P32898 →
Q06010	—	0.987	Q06010 →
O42908	—	0.987	O42908 →
P22817	—	0.984	P22817 →
Q6FUI7	—	0.983	Q6FUI7 →
O94745	—	0.982	O94745 →
P35559	—	0.981	P35559 →
Q12496	—	0.981	Q12496 →
Q9JHR7	—	0.981	Q9JHR7 →
Q95XN2	—	0.980	Q95XN2 →
F4HNU6	—	0.980	F4HNU6 →
F4J3D9	—	0.980	F4J3D9 →
IDE	Insulin-degrading enzyme	0.979	landscape →
O22941	—	0.979	O22941 →
O14077	—	0.977	O14077 →