PLA2G3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Varespladib (SCHEMBL26726)	1.00	1/20
SCHEMBL7682372	0.87	1/20
SCHEMBL818585	0.85	1/20
SCHEMBL5150404	0.84	1/20
Varespladib Methyl (SCHEMBL25678)	0.83	1/20
Varespladib (SCHEMBL1232548)	0.83	1/20
SCHEMBL5710595	0.82	1/20
SCHEMBL5710700	0.82	1/20
SCHEMBL5710708	0.82	1/20
SCHEMBL6812616	0.82	1/20
SCHEMBL5710565	0.80	1/20
SCHEMBL5710591	0.80	1/20
SCHEMBL7171270	0.80	1/20
SCHEMBL5710584	0.79	1/20
SCHEMBL7962736	0.79	1/20
SCHEMBL818498	0.79	1/20
SCHEMBL1514327	0.79	1/20
SCHEMBL7168376	0.78	1/20
SCHEMBL5153686	0.78	1/20
SCHEMBL5710556	0.78	1/20

Clinical trials — most relevant to PLA2G3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Eicosapentaenoic Acid Cerebral Vasospasm Therapy Study	PHASE4	COMPLETED
A Randomized Controlled Pilot Trial of Indomethacin in Acute Pancreatitis	PHASE3	COMPLETED
Aspirin and Renal Disease Progression in Patients With Type 2 Diabetes	PHASE3	UNKNOWN
Combined Treatment of Methotrexate + Glucocorticoids Versus Glucocorticoids Alone in Patients With PM and DM	PHASE3	COMPLETED
European Celecoxib Trial in Primary Breast Cancer	PHASE3	COMPLETED
Evaluate Rituximab Treatment for Idiopathic Membranous Nephropathy	PHASE3	COMPLETED
Montelukast for Early Life Wheezing	PHASE2/PHASE3	COMPLETED
Chemoprevention Trial in Familial Adenomatous Polyposis (FAP) Coli Using EPA	PHASE2/PHASE3	COMPLETED
Obinutuzumab Induced Decreases of PLA2R Antibodies in Membranous Nephropathy: a Pilot Study	PHASE2/PHASE3	RECRUITING
Lovaza's Effect on the Activation of Platelets	PHASE2	COMPLETED
Assessment of Coronary Plaque Composition	PHASE1	COMPLETED
Acute Pseudophakic Cystoid Macular Edema Treatment Trial: Intravitreal Ranibizumab Versus Triamcinolone Acetonide	PHASE1	COMPLETED
Mucomyst for Hepatitis C	nan	SUSPENDED
Plasma Free Fatty Acids Profile As A Diagnostic Tool For Acute Ischemic Stroke	nan	COMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN
PET Imaging of DHA Metabolism	nan	COMPLETED
Lipoprotein-associated Phospholipase A2 in Patients With Type 2 Diabetes	nan	COMPLETED
Role of PLA2G1B During HIV Infection	nan	UNKNOWN
Physiopathology of Pulmonary Arterial Hypertension: Mechanistic Studies	nan	UNKNOWN
Positron Emission Tomography (PET) to Study Brain Signaling	nan	COMPLETED
Investigation of Lipoxin A4, Annexin A1 and Interleukin-1 Beta Levels in Individuals With Periodontitis.	nan	COMPLETED
LDL-Apheresis for FSGS CardioRenal Outcomes	nan	COMPLETED
The Association Between Post-ERCP Acute Pancreatitis and Various Genetic Mutations	nan	COMPLETED
An Outcome Analysis of Primary Membranous Nephropathy	nan	RECRUITING
Rituximab, Cyclophosphamide, and Corticosteroids in Primary Membranous Nephropathy	nan	UNKNOWN
In-vivo Thrombus Imaging With 18F-GP1, a Novel Platelet PET Radiotracer	nan	COMPLETED
Eicosanoid Lipids by Airway Cells During Infection With Human Rhinoviruses	nan	COMPLETED
Investigation of Copy Number Variations and Genetic Variants in POI	nan	RECRUITING
Markers in Acute Pancreatitis-1	nan	COMPLETED
Lp-PLA2 and Coronary Atherosclerosis in Humans	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PLA2G3 binder may also engage these)

Protein	Name	Similarity
Q8BZT7	—	1.000	Q8BZT7 →
Q1JPB9	—	1.000	Q1JPB9 →
P20800	—	0.993	P20800 →
Q4TUC0	—	0.992	Q4TUC0 →
Q5NRQ0	—	0.991	Q5NRQ0 →
P13207	—	0.991	P13207 →
P23943	—	0.991	P23943 →
Q765Z5	—	0.991	Q765Z5 →
Q16610	—	0.990	Q16610 →
Q80UW3	—	0.990	Q80UW3 →
Q5NRP8	—	0.990	Q5NRP8 →
O76061	—	0.989	O76061 →
Q9BSG5	—	0.989	Q9BSG5 →
Q5DRQ5	—	0.989	Q5DRQ5 →
P22389	—	0.989	P22389 →
Q13790	—	0.989	Q13790 →
Q5BIR3	—	0.988	Q5BIR3 →
Q7TNI2	—	0.988	Q7TNI2 →
Q7TSF4	—	0.988	Q7TSF4 →
P35054	—	0.988	P35054 →
Q9Z0E3	—	0.988	Q9Z0E3 →
A0A140LIA7	—	0.987	A0A140LIA7 →
Q5XIX0	—	0.987	Q5XIX0 →
Q5NRQ1	—	0.987	Q5NRQ1 →
Q8BLY7	—	0.987	Q8BLY7 →
Q8C8N3	—	0.987	Q8C8N3 →
Q8BLR5	—	0.987	Q8BLR5 →
Q7TQH7	—	0.986	Q7TQH7 →
Q8N6Y0	—	0.986	Q8N6Y0 →
Q8K1T4	—	0.986	Q8K1T4 →